HBV - infection in children with perinatal infection. Clinical report of familial hepatitis B
https://doi.org/10.22625/2072-6732-2021-13-3-120-124
Abstract
Hepatitis B, despite of being a controlled infection today, is one of the most common form of hepatitis in the world. According to the experts' evaluation there are about 3 million patients with chronic hepatitis B in our country. The global strategy of the World Health Organization includes the elimination of viral hepatitis by 2030.
The program used in the North-West Federal District to eliminate acute hepatitis B has reduced the incidence rate due to the widespread vaccination coverage of children and the annual increase in adult immunization coverage.
However, the relevance of HBV-infection in children still remains high which is associated with a high infection by hepatitis B virus in women of childbearing age and the possibility of the transmission of the infection from mother to her child. In case of perinatal infection the formation of chronic hepatitis B in children reaches up to 90%. The natural course of chronic hepatitis B is characterized by a change in pathogenetically determined phases, and HBsAg-negative infection, which is a latent (occult) form of hepatitis, was added to them in 2009. Occult hepatitis B is an epidemiological danger, for the child as well, if the mother suffers from this form of chronic hepatitis B. Monitoring of pregnant women is often limited to identifying only HBsAg, which is not enough to detect occult hepatitis B. Lately diagnosed occult HBV-infection can become a source of the infection for the baby, especially in cases when due to some reasons there are disorders in hepatitis B vaccination schedule after birth. The article presents an interesting clinical case of family hepatitis B.
About the Authors
I. V. Shilova
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Competing Interests:
Russian Federation
Saint-Petersburg.
Competing Interests:
No
Yu. V. Ostankova
Saint-Petersburg Science Research Institute of Epidemiology and Microbiology named after Pasteur
Russian Federation
Competing Interests:
Russian Federation
Saint-Petersburg.
Competing Interests:
No
L. G. Goryacheva
Pediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical University
Russian Federation
Competing Interests:
Russian Federation
Saint-Petersburg.
Competing Interests:
No
A. V. Semenov
Saint-Petersburg Science Research Institute of Epidemiology and Microbiology named after Pasteur; North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Competing Interests:
Russian Federation
Saint-Petersburg.
Competing Interests:
No
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Review
For citations:
Shilova I.V., Ostankova Yu.V., Goryacheva L.G., Semenov A.V. HBV - infection in children with perinatal infection. Clinical report of familial hepatitis B. Journal Infectology. 2021;13(3):120-124. (In Russ.) https://doi.org/10.22625/2072-6732-2021-13-3-120-124
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