Preview

Journal Infectology

Advanced search

Prolonged subfebrile condition in children. Possible causes, diagnostics

https://doi.org/10.22625/2072-6732-2020-12-5-5-14

Abstract

Prolonged subfebrile condition (PSC) is a complex diagnostic and therapeutic problem caused by a wide variety of reasons, which often require a wide and expensive examination, consultations of various specialists, and repeated hospitalizations. Most often, PSC is associated with infections, some non-infectious diseases (predominantly connective tissue) and growths. To infectious causes of DS include: acute respiratory viral infections, herpes virus infections, toxoplasmosis, chlamydia, borreliosis, bartonellosis, etc. Separately, “psychogenic fevers”, subfebrile condition associated with taking drugs, and artifical subfebrile condition are distinguished. The condition of the children, as a rule, is benign and in most cases goes away on their own within 6-24 months.

About the Authors

S. V. Khaliullina
Kazan State Medical University
Russian Federation
Kazan


V. A. Anokhin
Kazan State Medical University
Russian Federation
Kazan


K. R. Khaliullina
Kazan State Medical University
Russian Federation
Kazan


E. M. Pokrovskaya
Kazan (Volga region) Federal University
Russian Federation
Kazan


References

1. Gompf SG. Fever of Unknown Origin (FUO) Differential Diagnoses. Medscape [Internet]. 2018. [Cited 17.01.2020] Available from: https://emedicine.medscape.com/article/217675- differential

2. Schmitt, B.D. Fever phobia: misconceptions of parents about fevers / B.D. Schmitt // Am J Dis Child. – 1980. – №134 (2). – P. 176–181. doi:10.1001/archpedi.1980.02130140050015

3. Fever phobia in Korean caregivers and its clinical implications / YH Kwak [et al.] // J Korean Med Sci. – 2013. – №28(11). – P.1639–1644. doi:10.3346/jkms.2013.28.11.1639

4. Low-grade fever: how to distinguish organic from non-organic forms / M. Affronti [et al.] // Int J Clin Pract. – 2010. – №64 (3). – P. 316–321. doi: 10.1111/j.1742-1241.2009.02256

5. Oka, T. Psychogenic fever: how psychological stress affects body temperature in the clinical population / T. Oka // Temperature (Austin). – 2015. – №2(3). P. 368–378. doi:10.10 80/23328940.2015.1056907

6. Zvereva, N.N. Lixoradka: prichiny`, oshibki, optimal`ny`j podxod / N.N.Zvereva, M.A.Sajfullin // Medicinskij sovet. – 2018. – №11. – S.158-161. doi: 10.21518/2079-701X-2018-11-158-161 (in Russian).

7. Bagirova, G.G. Algoritm diagnostiki pri lixoradke i subfebrilitete neyasnogo geneza: Uchebnoe posobie / G.G. Bagirova, L.V. Sizova, E`.R. Sagitova. – Orenburg: FGBOU VO OGMU MZ RF, 2012. – 100 s. (in Russian).

8. Torreggiani, S. Recurrent Fever in Children / S. Torreggiani, G. Filocamo, S. Esposito //Int J Mol Sci. – 2016. – №17 (4). – P. 448. doi: 10.3390/ijms17040448

9. Palazzi DL. Fever of unknown origin in children: Evaluation. UpToDate [Internet]. 2019. [Cited 17.01.2020] Available from: https://www.uptodate.com/contents/fever-of-unknownorigin-in-children-evaluation

10. Chow, A. Fever of unknown origin in children: a systematic review / A. Chow, J.L. Robinson // World J. Pediatr. – 2011. – №7. – P. 5 –10. doi: 10.1007/s12519-011-0240-5

11. Unexplained recurrent fever: When is autoinflammation the explanation? / T. Kallinich [et al.] // Allergy. – 2013. – №68. – P. 285–296. doi: 10.1111/all.12084

12. Broderick, L. Recurrent Fevers for the Pediatric Immunologist: It’s Not All Immunodeficiency / L. Broderick // Curr Allergy Asthma Rep. – 2016. – №16(1). – P. 2. doi: 10.1007/s11882-015-0578-1

13. Piram, M. Recurrent fevers in childhood / M. Piram, I. Koné-Paut //Presse Med. – 2015. – №44 (12 Pt 1). – P. 1266- 1275. doi: 10.1016/j.lpm.2015.09.012

14. Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study / Alirol E. [et al.] // PLoS Negl Trop Dis. – 2016. – № 10(11). – P. 1-7. doi: 10.1371/journal.pntd.0004749

15. Almeida de Jesus, A. Monogenic autoinflammatory diseases: concept and clinical manifestations / A. Almeida de Jesus, R. Goldbach-Mansky // Clin Immunol. – 2013. – № 147(3). – P. 155-174. doi: 10.1016/j.clim.2013.03.016

16. Duration of fever and serious bacterial infections in children: a systematic review / G. Elshout [et al.] // BMC Fam Pract. – 2011. – № 12(33). – P. 1-6. doi: 17.1186/1471-2296-12-33

17. Soon, GS Approach to recurrent fever in childhood / GS. Soon, RM. Laxer // Can Fam Physician. – 2017. – № 63(10). – P. 756–762.

18. Palazzi DL. Fever of unknown origin in children: Etiology. UpToDate [Internet]. 2019. [Cited 17.01.2020] Available from: https://www.uptodate.com/contents/fever-of-unknownorigin-in-children-etiology

19. Ward MA. Fever in infants and children: Pathophysiology and management. UpToDate [Internet]. 2019. [Cited 17.01.2020] Available from: https://www.uptodate.com/contents/fever-in-infants-and-children-pathophysiology-andmanagement

20. Fever of unknown origin: discrimination between infectious and non-infectious causes / SP. Efstathiou [et al.] // Eur J Intern Med. – 2010. – № 21(2). – P. 137-143. doi: 10.1016/j.ejim.2009.11.006

21. Jacobs, R.F. Bartonella henselae as a cause of prolonged fever and fever of unknown origin in children / R.F. Jacobs, G.E. Schutze // Clin Infect Dis. – 1998. – № 26(1). – 80 – 84.

22. Bourrillon, A. [Management of prolonged fever in infants] / A. Bourrillon // Arch Pediatr. – 1999. – № 6(3). – P. 330 – 335.

23. McGregor, AC. Infectious causes of fever of unknown origin / AC. McGregor, DA. Moore // Clin Med (Lond). – 2015. – № 15(3). – P. 285–287. doi:10.7861/clinmedicine.15-3-285

24. Bryazgunov, I.P. Dlitel`ny`j subfebrilitet u detej: klinika, e`tiologiya, patogenez i lechenie / I.P. Bryazgunov. – M.: Medicinskoe informacionnoe agentstvo, 2002. – 240 s. (in Russian).

25. Bryazgunov, I.P. Dlitel`ny`e subfebrilitety` u detej (klinika, patogenez, lechenie) / I.P. Bryazgunov. – 2-e izd. – M.: OOO «MIA», 2008. – 240 s. (in Russian).

26. Bryazgunov, I.P. Teploobmen i termoregulyaciya v praktike pediatra / I.P. Bryazgunov. – M.: ID Med-Praktika, 2005. – 128 s. (in Russian).

27. Semenova, L.Yu. Prichiny` dlitel`nogo subfebriliteta u detej. Vrach-aspirant. Medicinskij zhurnal [Internet]. 2013. [Data obrashheniya 17.01.2020] Dostupno s: https://vrach-aspirant.ru/articles/pediatrics/13117/ (in Russian).

28. Rol` gerpesvirusny`x infekcij pri dlitel`ny`x subfebrilitetax u detej / T.M. Lebedeva [i dr.] // Detskie infekcii. – 2013. – №4. – S. 23-27. (in Russian).

29. Dlitel`ny`j subfebrilitet v detskom vozraste: sovremenny`e aspekty` diagnosticheskogo poiska / E.G.Xramczova [i dr.] // Pediatr. – 2013. – T.IV, № 2. – S. 97-105. (in Russian).

30. Shabalov, N.P. Detskie bolezni: Uchebnik dlya VUZov. 6-e izd. V dvux tomax. T. 1. / N.P. Shabalov. – 6-e izd. – SPb.: Piter, 2011. – 928 s. (in Russian).

31. Campanella, N. Low temperature with prolonged flow. A retrospective study of 30 cases and thoughts for low-cost management / N. Campanella, M. Pergolini, P. Morosini // Recenti Prog Med. – 1998. – № (7-8). – P. 377-380.

32. Fever of unknown origin − diagnostic methods in a European developing country / M. Bosilkovski [et al.] // Vojnosanitetski pregled. – 2016. – № 73. – P. 1-7. doi: 10.2298/VSP140827050B

33. Bezkaravajnij, B.O. Algoritm diagnostiki pri subfebrilitete u detej / B.O. Bezkaravajnij, O.M. Voloshin // Zdorov`e rebenka. – 2007. – №4 (7). – S. 100-105. (in Russian).

34. Yulish, E.I. Dlitel`ny`j subfebrilitet u detej. Vozmozhny`e prichiny` i podxody` k terapii / E.I. Yulish, O.E. Cherny`sheva, Yu.A. Soroka // Aktual`ny`e voprosy` pediatrii. – 2011. – № 1 (35). – S. 67–72. (in Russian).

35. Klinicheskie rekomendacii «Lixoradka bez ochaga infekcii u detej», Soyuz pediatrov Rossii. [Internet]. [Data obrashheniya 17.01.2020] Dostupno s: http://www.pediatr-russia.ru/sites/default/files/file/kr_lboi.pdf (in Russian).

36. Pasieshvili, L.M. Diagnosticheskie podxody` pri sindrome subfebriliteta / L.M. Pasieshvili // Vostochnoevropejskij zhurnal vnutrennej i semejnoj mediciny`. – 2017. – №1. – S. 23 – 30. (in Russian).

37. Lixoradka neyasnogo geneza (v pomoshh` praktikuyushhemu vrachu) / L.M.Czogoeva [i dr.] // Medicina neotlozhny`x sostoyanij. – 2014. – № 5(60). – S. 40-45. (in Russian).

38. Soldatova, O.N. Prichiny` dlitel`nogo subfebriliteta u detej / O.N. Soldatova, S.V. Vorob`eva // Mezhdunarodny`j nauchno-issledovatel`skij zhurnal. – 2013. – № 10-5 (17). – S. 30-31. (in Russian).

39. Rol` gerpesvirusnoj infekcii IV, V i VI tipov v infekcionnoj i somaticheskoj patologii u detej / F.S. Xarlamova [i dr.] // Pediatriya. Zhurnal im. G.N. Speranskogo. – 2017. – T.96, № 4. – S. 42-47. (in Russian).

40. Tuberculosis as a cause of recurrent fever of unknown origin / J. Collazos [et al.] // J Infect. – 2000. – № 41(3). – P. 269-272. doi: 10.1053/jinf.2000.0727

41. Elder, R.W. The changing epidemiology of pediatric endocarditis // R.W. Elder, R.S. Baltimore // Infect. Dis. Clin. North Am. – 2015. – № 29(3). – P. 513–524. doi: 10.1016/j.idc.2015.05.004

42. Lixoradka u detej: ot simptoma k diagnozu / I.N.Zaxarova [i dr.] // Medicinskij sovet. – 2017. – №1. – S. 212-218. (in Russian).

43. Psychological stress contributed to the development of low-grade fever in a patient with chronic fatigue syndrome: a case report / T. Oka [et al.] // Biopsychosoc Med. – 2013. – № 7(1). – P. 1-6. doi: 10.1186/1751-0759-7-7

44. Semenova, L.Yu. Kliniko-psixologicheskie osobennosti i kachestvo zhizni podrostkov s dlitel`noj subfebril`noj temperaturoj tela, associirovannoj i ne associirovannoj s gipotalamicheskim sindromom / L.Yu.Semenova, M.B.Kolesnikova // Kazanskij medicinskij zhurnal. – 2014. – T.95, № 2. – S. 235-240. (in Russian).

45. McDonald M, Sexton D. Drug fever. Medscape [Internet]. 2018. [Cited 17.01.2020] Available from: https://www.uptodate.com/contents/drug-fever

46. Klinicheskie rekomendacii «Yunosheskij artrit s sistemny`m nachalom», Soyuz pediatrov Rossii. [Internet]. 2017. [Data obrashheniya 17.01.2020] Dostpuno s: http://www. pediatr-russia.ru/sites/default/files/file/kr_yuassn.pdf (in Russian).

47. Hofer, M. A child with a systemic febrile illness–differential diagnosis and management // M. Hofer, N. Mahlaoui, A. Prieur // Best Pract. Res. Clin. Rheumatol. – 2006. – № 20(4) – P. 627-640. doi: 10.1016/j.berh.2006.04.001

48. Prolonged fevers of unknown origin in children: patterns of presentation and outcome / L.C. Miller // J Pediatr. – 1996. – № 129. – P. 419–423. doi: 10.1016/S0022-3476(96)70075-6

49. Rosen, MJ. Inflammatory Bowel Disease in Children and Adolescents // MJ. Rosen, A. Dhawan, SA. Saeed // JAMA Pediatr. – 2015. – № 169(11). – P. 1053–1060. doi:10.1001/jamapediatrics.2015.1982

50. Periodicheskie lixoradki v praktike detskogo vracha / R.R.Shilyaev [i dr.] // Vestnik Ivanovskoj medicinskoj akademii. – 2013. – T.18., №4. – S.51-55. (in Russian).

51. Renbourn, ET. Body temperature and pulse rate in boys and young men prior to sporting contests. A study of emotional hyperthermia: with a review of the literature / ET. Renbourn // J Psychosom Res. – 1960. – № 4. – P. 149-175. doi: 10.1016/0022-3999(60)90008-8

52. Marazziti, D. Psychological stress and body temperature changes in humans / D. Marazziti, A. Di Muro, P. Castrogiovanni // Physiol Behav. – 1992. – № 52(2). – P. 393-395. doi: 10.1016/0031-9384(92)90290-i

53. Briese, E. Emotional hyperthermia and performance in humans / E. Briese // Physiol Behav. – 1995. – № 58. – P. 615-618. doi: 10.1016/0031-9384(95)00091-v

54. Korovina, N.A. Lixoradka. Mnogoobrazie prichin i slozhnost` resheniya / N.A. Korovina, I.N. Zaxarova, E.M. Ovsyannikova // Medicinskij sovet. – 2013. – №2. – S. 82-90. (in Russian).

55. Pediatru – o lixoradochny`x sostoyaniyax u detej: chto nuzhno znat` i umet` / I.N.Zaxarova [i dr.] // Medicinskij sovet. – 2016. – №1. – S. 140-147. (in Russian).


Review

For citations:


Khaliullina S.V., Anokhin V.A., Khaliullina K.R., Pokrovskaya E.M. Prolonged subfebrile condition in children. Possible causes, diagnostics. Journal Infectology. 2020;12(5):5-14. (In Russ.) https://doi.org/10.22625/2072-6732-2020-12-5-5-14

Views: 3585


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-6732 (Print)