Immune and genetic mechanism of hepatitis C virus persistence after mother-to-child transmission (Review of English language publications)
https://doi.org/10.22625/2072-6732-2012-4-3-16-29
Abstract
Chronic viral hepatitis C is one of the major health challenges in the present decade. Every year about 3–4 million of newly infected patients added to reservoir of infection that according to the experts estimates contain more than 170 million of individuals. After introduction of the routine blood products screening for hepatitis C virus, mother-to-child transmission became the major source of hepatitis C infection in childhood. This review represent the modern understanding of the genetic and immune mechanism of hepatitis C virus persistence after mother-to-child transmission, development of innate chronic hepatitis C, current practices and perspectives for its prevention presented in English language sources of scientific information.
About the Authors
Yu. V. Lobzin
Scientific and research institute of children’s infections FMBA of Russia, Saint-Petersburg
Russian Federation
Russian Federation
D. A. Gusev
Military medical academy named by S.M. Kirov, Saint-Petersburg
Russian Federation
Russian Federation
A. A. Lutckiy
Scientific and research institute of children’s infections FMBA of Russia, Saint-Petersburg
Russian Federation
Russian Federation
References
1. Басараба, Н.М. Врожденный гепатит: современные подходы к диагностике и пути профилактики / Н.М. Басараба // Перинатология и педиатрия. – 2009. – Т. 40, № 4. – С. 79–83.
2. Белопольская, М.А. Особенности беременности, родов и состояние новорожденных у женщин с хроническим вирусным гепатитом С и ВИЧ-инфекцией : автореф. дис. ... канд. мед. наук / М.А. Белопольская. – М., 2003. – 121 c.
3. Гурская, Т.Ю. Беременность и хронический HCV-гепатит: вопросы патогенеза, клиники, диагностики, состояния фето-плацентарной системы. Автореф. дис. … д-ра мед. наук / Т.Ю. Гурская. – М., 2006. – 48 c.
4. Дегтярева, А.В. Дифференциальная диагностика и принципы этиопатогенетического лечения заболеваний печени и желчных путей у новорожденных и детей раннего возраста : автореф. дис. … д ра мед. наук /А.В. Дегтярева. – М., 2008. – 48 c.
5. Ершова, О.Н. Характеристика активности перинатальной передачи вируса гепатита С. / О.Н. Ершова, И.В. Шахгильдян, С.Н. Кузин // Эпидемиология и инфекционные болезни. – 2005. – № 1. – С. 39–41.
6. Игнатова, Т.М. Хронический гепатит С и беременность / Т.М. Игнатова // Клиническая гепатология. – 2008. – № 1. – С. 3–9.
7. Сологуб, Т.В. Характер течения беременности и родов у больных хроническим вирусным гепатитом С в зависимости от состояния внешней среды : пособие для врачей / Т.В. Сологуб, М.Н. Погромская, Т.Г. Невзорова. – СПб., 2003. – 38 с.
8. Татиева, З.Д. Клинико-эпидемиологическая характеристика гепатитов В и С у беременных / З.Д. Татиева, О.В. Платошина, А.Н.Каменцева / Сб. мат. I конф. Северо-Западного региона России «Инфекционный контроль в ЛПУ». – СПб., 2000. –С. 16–19.
9. Чуйкова, К.И. Хронические вирусные гепатиты B и C во время беременности (стратегия минимизации риска вертикальной передачи инфекции) / К.И. Чуйкова, Т.А. Ковалева, И.Д. Евтушенко // Лечащий врач. – 2009. – № 11. –С. 68–71.
10. Шехтман, М.М. Хронический гепатит и цирроз печени у беременных / М.М. Шехтман // гинекология. – 2004. – № 6. – С. 3.
11. Kisteneva, L.B. Perinatal transmission of hepatitis C virus. / L.B. Kisteneva [et al.] // Vopr Virusol. – 2009. – V. 54,№ 1. – P. 12–15.
12. Лобзин, Ю.В. Новые возможности и перспективы лечения поражений печени у детей. / Ю.В. Лобзин, Л.Г. Горячева, Н.В. Рогозина // Журнал инфектологии. – 2010. – Т. 2, № 2. – С. 6–13.
13. Martins, T. Epidemiology of hepatitis C virus infection /T. Martins [et al.] // Rev. Assoc. Med. Bras. – 2011. – V. 57, № 1. – P. 107–112.
14. Pembrey, L. The management of HCV infected pregnant women and their children European paediatric HCV network. /L. Pembrey [et al.] // J. Hepatol. – 2005. – V. 43, № 3. – P. 515–525.
15. Babik, J.M. The human fetal immune response to hepatitis C virus exposure in utero. / J.M. Babik [et al.] // J. Infect. Dis. – 2011. – V. 203, № 2. – P. 196–206.
16. Ishii, T. Evolution in the hypervariable region of the hepatitis C virus in two infants infected by mother-to-infant transmission. / T. Ishii [et al.] // Pediatr Int. – 2005. – V. 47, № 3. – P. 278–85.
17. Steininger, C. Increased risk of mother-to-infant transmission of hepatitis C virus by intrapartum infantile exposure to maternal blood. / C. Steininger [et al.] // J. Infect. Dis. – 2003. – V. 187, № 3. – P. 345–351.
18. Azzari, C. Vertical transmission of HCV is related to maternal peripheral blood mononuclear cell infection. / C. Azzari [et al.] // Blood. – 2000. – V. 96, № 6. – P. 2045–2048.
19. Hurtado, C.W. Innate immune function in placenta and cord blood of hepatitis C-seropositive mother-infant dyads. / C.W. Hurtado [et al.] // PLoS One. – 2010. – V. 5, № 8. – P. 96–121.
20. Mast, E.E. Mother-to- infant hepatitis C virus transmission and breastfeeding. / E.E. Mast // Adv. Exp. Med. Biol. –2004. – V. 554. – P. 211–216.
21. Martell, M. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution / M. Martell [et al.] // J. Virol. – 1992. – V. 66, № 5. – P. 3225–3229.
22. Li, H. Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time / H. Li [et al.] // PLoS One. – 2011. – V. 6, № 5. – P. 113–119.
23. Farci, P. Clinical significance of hepatitis C virus genotypes and quasispecies / P. Farci, R.H. Purcell. // Semin Liver Dis. – 2000. – V. 20, № 1. – P. 103–126.
24. Fishman, S.L. The quasispecies nature and biological implications of the hepatitis C virus / S.L. Fishman, A.D. Branch //Infect Genet Evol. – 2009. – V. 9, № 6. – P. 1158–1167.
25. Murakami, J. Evolution in the hypervariable region of hepatitis C virus in infants after vertical transmission. / J. Murakami [et al.] // Pediatr Res. – 2000. – V. 48, № 4. – P. 450– 456.
26. Farmand, S. Spontaneous clearance of hepatitis C virus in vertically infected children. / S. Farmand [et al.] // Eur. J. Pediatr. – 2012. – V. 171, № 2. – P. 253–258.
27. Farci, P. Evolution of hepatitis C viral quasispecies and hepatic injury in perinatally infected children followed prospectively / P. Farci [et al.] // Proc. Natl. Acad. Sci. USA. – 2006. – V. 103, № 22. – P. 8475–8480.
28. Remington, J.S. Infectious Diseases of the Fetus and Newborn: Expert Consult (INFECTIOUS DISEASES OF THE FETUS AND NEWBORN INFANT) / J.S. Remington [et al.] // – 2011. – V. 15 – P. 1280.
29. Asselah, T. Genetics, genomics, and proteomics: implications for the diagnosis and the treatment of chronic hepatitis C / T. Asselah [et al.] // Semin Liver Dis. – 2007. – V. 27, № 1. – P. 13–27.
30. Neumann-Haefelin, C. Success and failure of virusspecific T cell responses in hepatitis C virus infection / C. Neumann- Haefelin, R.N.-H. Thimme, R. Thimme // Dig. Dis. – 2011. – V. 29, № 4. – P. 416–422.
31. Bevilacqua, E. Genetic factors in mother-to-child transmission of HCV infection / E. Bevilacqua [et al.] // Virology. – 2009. – V. 390, № 1. – P. 64–70.
32. Ruiz-Extremera, A. Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV-infected children / A. Ruiz- Extremera [et al.] // Hepatology. – 2011. – V. 53, № 6. – P. 1830–1838.
33. Hashem, M. Strong hepatitis C virus (HCV)-specific cellmediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children / M. Hashem [et al.] // J Infect Dis. – 2011. – V. 203, № 6. – P. 854–861.
34. Della Bella, S. Hepatitis C virus-specific reactivity of CD4+-lymphocytes in children born from HCV-infected women / S. Della Bella [et al.] // J. Hepatol. – 2005. – V. 43, № 3. – P. 394–402.
35. Giovannetti, A. T-Cell immune activation in children with vertically transmitted hepatitis C virus infection. / A. Giovannetti [et al.] // Viral Immunol. – 2001. – V. 14, № 2. – P. 169–179.
36. Boxall, E. Discordant outcome of perinatal transmission of hepatitis C in twin pregnancies / E. Boxall [et al.] // J. Clin. Virol. – 2007. – V. 38, № 2. – P. 91–95.
37. Tarr, A.W. The role of humoral innate immunity in hepatitis C virus infection / A.W. Tarr [et al.] // Viruses. – 2012. – V. 4, № 1. – P. 1–27.
38. Ito, M. Peripheral B cells may serve as a reservoir for persistent hepatitis C virus infection / M. Ito [et al.] // J. Innate. Immun. – 2010. – V. 2, № 6. – P. 607–617.
39. Machida, K. Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein / K. Machida [et al.] // J. Virol. – 2008. – V. 82, № 13. – P. 6711–6720.
40. Ito, M. HCV infection and B-cell lymphomagenesis /M. Ito [et al.] // Adv Hematol. – 2011. – P. 57–84.
41. Meunier, J.C. Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively / J.C. Meunier [et al.] // J. Infect. Dis. – 2011. – V. 204, № 11. – P. 1741–1745.
42. Meyer, K. Antibody-dependent enhancement of hepatitis C virus infection / K. Meyer [et al.] // J. Virol. – 2008. – V. 82, № 5. – P. 2140–2149.
43. Klade, C.S. Hepatitis C virus-specific T cell responses against conserved regions in recovered patients / C.S. Klade [et al.] // Vaccine. – 2009. – V. 27, № 23. – P. 3099–3108.
44. Soderholm, J. Relation between viral fitness and immune escape within the hepatitis C virus protease / J. Soderholm [et al.] // Gut. – 2006. – V. 55, № 2. – P. 266–274.
45. Oniangue-Ndza, C. Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase / C. Oniangue-Ndza [et al.] // J. Virol. – 2011. – V. 85, № 22. – P. 11883–11890.
46. Petrovic, D. Hepatitis C virus--T-cell responses and viral escape mutations / D. Petrovic [et al.] // Eur. J. Immunol. – 2012. – V. 42, № 1. – P. 17–26.
47. Klenerman, P. T cell responses in hepatitis C: the good, the bad and the unconventional / P. Klenerman, R.K. Thimme, R. Thimme // Gut. – 2011. – P. 321–326.
48. Bowen, D.G. Adaptive immune responses in acute and chronic hepatitis C virus infection / D.G. Bowen, C.M.B. Walker, C.M. Walker // Nature. – 2005. – V. 436, № 7053. – P. 946–952.
49. Wherry, E.J. T cell exhaustion / E.J.W. Wherry // Nat. Immunol. – 2011. – V. 12, № 6. – P. 492–499.
50. Raziorrouh, B. Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection / B. Raziorrouh [et al.] // Gastroenterology. – 2011. – V. 141, № 4. – P. 1422–1431.
51. Saito, K. Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and in-duces interleukin-10 production / K. Saito [et al.] // J. Virol. – 2008. – V. 82, № 7. – P. 3320–3328.
52. Bolacchi, F. Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels / F. Bolacchi [et al.] // Clin. Exp. Immunol. – 2006. – V. 144, № 2. – P. 188–196.
53. Smyk-Pearson, S. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection / S. Smyk-Pearson [et al.] // J. Infect. Dis. – 2008. – V. 197, № 1. – P. 46–57.
54. Arshad, M. Hepatitis C virus infection during pregnancy and the newborn period--are they opportunities for treatment? / M. Arshad [et al.] // J. Viral. Hepat. – 2011. – V. 18, № 4. – P. 229–236.
Review
For citations:
Lobzin Yu.V., Gusev D.A., Lutckiy A.A. Immune and genetic mechanism of hepatitis C virus persistence after mother-to-child transmission (Review of English language publications). Journal Infectology. 2012;4(3):16-29. (In Russ.) https://doi.org/10.22625/2072-6732-2012-4-3-16-29
Views:
1202
.png)
.png)
Email this article 