Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V
https://doi.org/10.22625/2072-6732-2020-12-1-104-110
Abstract
The case of chronic hepatitis C 1b genotype with grade 3 fibrosis according to Metavir, complicated by the development of mixed type III cryoglobulinemia, cryoglobulinemic vasculitis with damage to the skin vessels of the skin (hemorrhagic vasculitis), and the liver (alternatively proliferative vasculitis) is demonstrated. The introduction of daclatasvir + asunaprevir was virologically unsuccessful: mutations D168E and L31V were detected against the background of a virological breakthrough. A repeated course of antiviral therapy with the combination of Grazoprevir + Elbasvir in combination with sofosbuvir led to a stable virologic response, partial immunological and clinical remission.
About the Authors
N. V. Dunaeva
Centers for AIDS and Other Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
M. A. Chirskaya
Centers for AIDS and Other Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
E. Yu. Kolpashchikova
Centers for AIDS and Other Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
S. Yu. Romanova
Centers for AIDS and Other Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
S. V. Lapin
First Saint-Petersburg State Medical University named after academician I.P. Pavlov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. E. Karev
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Saint-Petersburg
Competing Interests:
Russian Federation
Saint-Petersburg
Competing Interests:
Карев Вадим Евгеньевич – заведующий лабораторией патоморфологии клиники, д.м.н.
Санкт-Петербург, тел.: 8(812)234-96-23
D. A. Gusev
Centers for AIDS and Other Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
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Review
For citations:
Dunaeva N.V., Chirskaya M.A., Kolpashchikova E.Yu., Romanova S.Yu., Lapin S.V., Karev V.E., Gusev D.A. Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V. Journal Infectology. 2020;12(1):104-110. (In Russ.) https://doi.org/10.22625/2072-6732-2020-12-1-104-110
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