Systemic meningococcal disease in children: survival analysis, Arkhangelsk region, Northwest Russia, 1991–2011
https://doi.org/10.22625/2072-6732-2012-4-2-60-66
Abstract
Systemic meningococcal infection requires prompt and adequate medical care. It is considered as unpredictable disease due to extreme severity of a patient’s condition and high risk for fatal outcome. Survival of the children with systemic meningococcal infection was studied. Retrospective cohort includes all cases of systemic meningococcal disease in children arose in Arkhangelsk region in 1991–2011. Rate of fatal outcomes was high (41%). All death cases occurred during first three days of illness. Survival of the patient with correct pre-admission diagnosis was higher in comparison with initially undiagnosed cases. Survival functions were influenced by form of the disease and presence of septic shock. The usage of intramuscular injection of glucocorticoids on pre-admission stage according to the common recommendations did not improve the outcome.
About the Authors
O. V. Samodova
Northern State Medical University, Arkhangelsk
Russian Federation
Russian Federation
E. A. Krieger
Northern State Medical University, Arkhangelsk
Russian Federation
Russian Federation
L. V. Titova
Northern State Medical University, Arkhangelsk
Russian Federation
Russian Federation
O. Yu. Leont’eva
Northern State Medical University, Arkhangelsk
Russian Federation
Russian Federation
U. V. Sukhanov
Northern State Medical University, Arkhangelsk
Russian Federation
Russian Federation
References
1. Акопова, Н.Е. Государственный доклад «О санитарно-эпидемиологической обстановке в Российской Федерации в 2010 году»/ Н.Е. Акопова, А.Э. Петров – М: Федеральный центр гигиены и эпидемиологии Роспотребнадзора, 2010. – 297–327.
2. Lai, I. Meningococcal Disease in Taiwan 1996–2001: Epidemiology and Risk Factors for Death / I. Lai, K. Chen, C. Huang // Epidemiology Bulletin. – 2008. № 24. – Р. 461– 475.
3. Thorburn, K. Mortality in severe meningococcal disease /K. Thorburn [et al.] // Arch. Dis. Child. – 2001. – № 85. Р. 382–385.
4. Lodder, M.C. Prognostic indicators of the outcome of meningococcal disease: a study of 562 patients / M.C. Lodder [et al.] // J. Med. Microbiol. – 1996. – № 45. – Р. 16–20.
5. Darton, T. Severity of Meningococcal Disease Associated with Genomic Bacterial Load / T. Darton [et al.] // Clin. Infect. Dis. – 2009. – № 48. – Р. 587–594.
6. Феклисова, Л.В. Многолетнее наблюдение за показателями заболеваемости и летальности при менингококковой инфекции у детей Московской области / Л.В. Феклисова // Инфекционные болезни. – 2004. – Т. 2, № 3. – С.68–71.
7. Скрипченко, Н.В. Анализ и уроки летальных исходов менингококковой инфекции у детей / Н.В. Скрипченко [и др.] // Эпидемиология и инфекционные болезни. – 2009. – № 5. – С. 31–34.
8. Скрипченко, Н.В. Менингококковоая инфекция у детей / Н.В. Скрипченко [и др.] // Эпидемиология и инфекционные болезни. – 2005. – № 5. – С. 20–27.
9. Скрипченко, Н.В. Возрастные клинико-эпидемиологические особенности менингококковой инфекции у детей и пути ее совершенствования / Н.В. Скрипченко [и др.] // Эпидемиология и инфекционные болезни. – 2010. – №1. – С. 35–40.
10. Менингококковая инфекция у детей (эпидемиология, клиника, диагностика, терапия и профилактика) : методические рекомендации / под ред. заслуженного деятеля науки РФ, проф. акад. РАМН Ю.В. Лобзина. – СПб., 2009. – 60 с.
11. Cloke, A. Management of bacterial meningitis and meningococcal septicaemia in children and young people younger than 16 years in primary and secondary care / A. Cloke [et al.]. – London: National Collaborating Centre for Women’s and Children’s Health Commissioned by the National Institute for Health and Clinical Excellence, 2010. – 271 р.
12. Крившич, Т.С. Влияние различных факторов на исход менингококковой инфекции у детей / Т.С. Крившич, Л.А. Гульман // Детские инфекции. – 2004. – № 3. – С. 69–70.
13. Clarke, C. State-Based surveillance to determine trends in meningococcal disease / C. Clarke, S. Mallonee // Public Health Reports. – 2009. – № 124. – Р. 280–287.
Review
For citations:
Samodova O.V., Krieger E.A., Titova L.V., Leont’eva O.Yu., Sukhanov U.V. Systemic meningococcal disease in children: survival analysis, Arkhangelsk region, Northwest Russia, 1991–2011. Journal Infectology. 2012;4(2):60-66. (In Russ.) https://doi.org/10.22625/2072-6732-2012-4-2-60-66
Views:
789
.png)
.png)
Email this article 