REAL-TIME ELASTOGRAPHY AND ITS CLINICAL APPLICATION COMPARED WITH OTHER METHODS FOR EVALUATION OF THE LIVER FIBROSIS DEGREE IN PATIENTS WITH CHRONIC HEPATITIS C
https://doi.org/10.22625/2072-6732-2018-10-3-84-90
Abstract
In this work we investigated to which extent the evaluation results of the degree of hepatic fibrosis obtained by realtime elastography (RTE) method are compatible with the results of the transient elastography (TE) and with the APRI indexes. We also analyzed the factors which can influence the reliability of the fibrosis degree evaluation obtained by different methods.
Materials and methods. The study included 99 patients (60 women and 39 men) with HCV, examined in the polyclinic department of the Saint-Petersburg Botkin clinical infectious hospital in 2017. In 83 patients, the fibrosis degree in the liver tissue has been evaluated by the RTE method using HI VISION Preirus (Hitachi, Japan) with a linear sensor. In 67 patients, the evaluation has been performed by the TE method using Fibroscan (Echosens, France). Both methods have been applied to 51 patients.
Conclusions. The aplication results of the RTE and TE methods do not differ significantly for patients with a severe fibrosis. Usually, the degree of fibrosis in patients with CHC obtained by the RTE is higher than the one obtained by the TE in the same patient. Due to the possibility to visualize a larger area under study, the RTE method has clear advantages in evaluating the degree of fibrosis in liver tissue in patients with focal changes in the liver. If the results obtained by the RTE and TE methods differ significantly, alternative methods must be used, such as a liver biopsy and biochemical methods.
About the Authors
M. A. Belopolskaya
Clinical Infectious Diseases Hospital named after S.P. Botkin;
Institute of Experimental Medicine
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. Yu. Avrutin
Institute for Systems Theory
Germany
Stuttgart
Germany
Stuttgart
O. D. Denisova
Clinical Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
E. V. Lichnaya
Saint-Petersburg Science Research Institute of Epidemiology and Microbiology named after Pasteur
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
E. Yu. Yushina
Clinical Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
S. I. Gurina
Clinical Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. V. Dmitriev
Institute of Experimental Medicine;
Saint-Petersburg State University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. A. Yakovlev
Clinical Infectious Diseases Hospital named after S.P. Botkin;
Saint-Petersburg State University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
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For citations:
Belopolskaya M.A., Avrutin V.Yu., Denisova O.D., Lichnaya E.V., Yushina E.Yu., Gurina S.I., Dmitriev A.V., Yakovlev A.A. REAL-TIME ELASTOGRAPHY AND ITS CLINICAL APPLICATION COMPARED WITH OTHER METHODS FOR EVALUATION OF THE LIVER FIBROSIS DEGREE IN PATIENTS WITH CHRONIC HEPATITIS C. Journal Infectology. 2018;10(3):84-90. (In Russ.) https://doi.org/10.22625/2072-6732-2018-10-3-84-90
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