MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS
https://doi.org/10.22625/2072-6732-2018-10-3-23-29
Abstract
There is introduced the analysis of molecular-genetic mechanisms of tropical malaria pathogenesis and P. falciparum virulence. It is shown, that pathogenesis of tropical malaria is associated with the properties of red blood cells membrane surface (RBCs or erythrocytes) that are infected by P. falciparum. There are «knobs structures» on membrane surface infected RBCs. Knobs structures contains a complex of P. falciparum proteins – PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1). PfEMP1 is associated with virulence of P. falciparum. Complex PfEMP1 has difficult polymorphous structure. Domains of PfEMP1 are able to associate with different cell receptors. Virulence`s individual components of the main factor are selectively sensitive to different tissues and organs. The severity of the clinical malaria infection course depends on the complex structure PfEMP1 of malaria parasites. Composition of polypeptide PfEMP1 is determined by var-complex. Nowadays there are 60 variants of var-complex. Regulation of gene expression, forming part of the var-complex, is carried out on a molecular-genetic level, cellular level, tissue level. Modern research in this area are aimed to explore genes polymorphism of the virulence`s main factor, to identify mechanism of its differential expression. Search of molecular – genetic markers is relevant to develop methods of gene diagnostic and malaria vaccine.
About the Authors
A. N. Uskov
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. I. Soloviev
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. Yu. Kravtsov
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
R. V. Gudkov
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
E. V. Kolomoets
Medical serves of Compagnie des Bauxites de Kindia (СВК of UC Rusal)
Guinea
Conakry
Guinea
Conakry
A. E. Levkovskiy
«Phrygia» hospital
Guinea
Conakry
Guinea
Conakry
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Review
For citations:
Uskov A.N., Soloviev A.I., Kravtsov V.Yu., Gudkov R.V., Kolomoets E.V., Levkovskiy A.E. MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS. Journal Infectology. 2018;10(3):23-29. (In Russ.) https://doi.org/10.22625/2072-6732-2018-10-3-23-29
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