ASSESMENT OF ADHERENCE TO ARVT IN HIV-POSITIVE PATIENTS WITH ALCHOHOL ABUSE
https://doi.org/10.22625/2072-6732-2018-10-1-29-35
Abstract
Purpose: to analyze prevalence of alcohol abuse and influence of alcohol abuse on adherence to ARVT in HIV-positive patients.
Research materials: we performed an anonymous survey of 165 HIV-positive patients hospitalized in Clinical Infectious Diseases Hospital named after S.P. Botkin in 2017.
Results: more than a half of participants has hazardous alcohol use or alcohol dependence. HIV-positive patients with alcohol abuse have high level of alcohol anosognosia. According to our survey among hospitalised patients, who didn’t take ARVT, 57% wasn’t ready to start antiretroviral therapy. Among patients, who were on ARVT at the time of evaluation, 92% had history of at least one episode of treatment interruption. Most common reason for interruption of antiretroviral therapy was drug’s side effect (36,5%). Alcohol was mentioned as a cause of interruption by 7,7% of participants. Level of adherence was significantly different among patients with different alcohol consumption pattern. Adherence measured with different self-assessment tools was low among hospitalized HIV-positive patients.
Conclusion: Hazardous drinking and alcohol dependence is very common among hospitalized HIV-positive patients. Suggested adherence self-assessment tools should help doctors to detect patients with insufficient level of adherence to ARVT.
About the Authors
A. A. Yakovlev
Staint-Petersburg State University
Russian Federation
Russian Federation
A. G. Diachkov
First Saint-Petersburg State Medical University named after academician I.P. Pavlov;
Clinical Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Russian Federation
V. B. Musatov
Staint-Petersburg State University
Russian Federation
Russian Federation
O. V. Ayzsilnieks
First Saint-Petersburg State Medical University named after academician I.P. Pavlov
Russian Federation
Russian Federation
E. V. Strelyanaya
Clinical Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Russian Federation
D. D. Avdoshina
Staint-Petersburg State University
Russian Federation
Russian Federation
References
1. Ladnaya N.N., Pokrovskii V.V., Dement’eva L.A., Lipina E.S. Development of HIV-infection epidemic in Russian Federation in 2016 Materialy mezhdunarodnoi nauchno-prakticheskoi konferentsii “Aktual’nye voprosy VICh-infektsii. Zhenshchiny i VICh”, Sankt-Peterburg, 2017. pp. 3-9.
2. Cohen, M.S. et al. Prevention of HIV-1 Infection with Early Antiretroviral Therapy. The New England Journal of Medicine. 2011 Aug 11; 365(5):493-505
3. Antiretroviral treatment as prevention (TASP) of HIV and TB. WHO/HIV/2012.12 © World Health Organization 2012 Available at: http://apps.who.int/iris/bitstream/10665/70904/1/WHO_HIV_2012.12_eng.pdf (Accessed 10.12.2017).
4. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV ISBN 978-92-4-150956-5 © World Health Organization 2015 Available at: http://apps. who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1 (Accessed 10.12.2017).
5. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, Wagener MM, Singh N. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000 Jul 4;133(1):21-30.
6. Adherence to long-term therapies: evidence for action» ISBN 92-4-154599-2 © World Health Organization 2003 Available at: http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf?ua=1 (Accessed 10.12.2017).
7. Youn B, Shireman TI, Lee Y, Gal rraga O, Rana AI, Justice AC, Wilson IB. Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries. AIDS. 2017 Jul 31;31(12):1697-1707. doi: 10.1097/QAD.0000000000001541.
8. Becker BW, Thames AD, Woo E, Castellon SA, Hinkin CH. Longitudinal change in cognitive function and medication adherence in HIV-infected adults. AIDS Behav. 2011 Nov;15(8):1888-94. doi: 10.1007/s10461-011-9924-z.
9. Mekuria LA, Prins JM, Yalew AW, Sprangers MA, Nieuwkerk PT. Which adherence measure – self-report, clinician recorded or pharmacy refill – is best able to predict detectable viral load in a public ART programme without routine plasma viral load monitoring? Trop Med Int Health. 2016 Jul;21(7):856- 69. doi: 10.1111/tmi.12709. Epub 2016 May 18.
10. Steel G., Nwokike J., Joshi M. 2007. Development of a Multi-method Tool to Measure ART Adherence in ResourceConstrained Settings: The South Africa Experience. Submitted to the U.S. Agency for International Development by the Rational Pharmaceutical Management Plus Program. Arlington, VA: Management Sciences for Health.
11. Thirumurthy H1, Siripong N, Vreeman RC, Pop-Eleches C, Habyarimana JP, Sidle JE, Siika AM, Bangsberg DR. Differences between self-reported and electronically monitored adherence among patients receiving antiretroviral therapy in a resource-limited setting. AIDS. 2012 Nov 28;26(18):2399-403. doi: 10.1097/QAD.0b013e328359aa68.
12. Kekwaletswe CT1, Morojele NK. Patterns and predictors of antiretroviral therapy use among alcohol drinkers at HIV clinics in Tshwane, South Africa. AIDS Care. 2014;26 Suppl 1:S78-82. doi: 10.1080/09540121.2014.906558. Epub 2014 Apr 14.
13. Рыбакова Ю.В., Илюк Р.Д., Крупицкий Е.М., Бочаров В.В., Вукс А.Я. Новый опросник «Алкогольная анозогнозия» для больных с алкогольной зависимостью, Журнал неврологии и психиатрии им. С.С. Корсакова, Т. 111, номер 11-2, год: 2011, с. 30-38
14. Balfour L1, Tasca GA, Kowal J, Corace K, Cooper CL, Angel JB, Garber G, Macpherson PA, Cameron DW. Development and validation of the HIV Medication Readiness Scale. Assessment. 2007 Dec;14(4):408-16.
15. The Alcohol Use Disorders Identification Test Guidelines for Use in Primary Care WHO/MSD/MSB/01.6a © World Health Organization Avaliable at: http://apps.who.int/iris/ bitstream/10665/67205/1/WHO_MSD_MSB_01.6a.pdf (Accessed 10.12.2017).
Review
For citations:
Yakovlev A.A., Diachkov A.G., Musatov V.B., Ayzsilnieks O.V., Strelyanaya E.V., Avdoshina D.D. ASSESMENT OF ADHERENCE TO ARVT IN HIV-POSITIVE PATIENTS WITH ALCHOHOL ABUSE. Journal Infectology. 2018;10(1):29-35. (In Russ.) https://doi.org/10.22625/2072-6732-2018-10-1-29-35
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