Brain biopsy for diagnosis of chlamydia encephalitis
https://doi.org/10.22625/2072-6732-2017-9-2-121-128
Abstract
This is the case of encephalitis associated with chlamydia infection of central nervous system. The diagnostic protocol of the patient included: a careful observation of somatic and neurological status, laboratory tests of blood and cerebrospinal fluid, neurovisualization. The results of the diagnostic protocol suggest that laboratory tests blood and cerebrospinal fluid possess low sensitivity and specificity. The MRI study has revealed the localization and inflammatory character of the changes in brain tissue; it has also helped to choose the most favorable area for the stereotaxic biopsy. The obtained tissue was evaluated by means of light (immunohistochemistry) and electronic microscopy. The active chlamydia infection was estimated. The subsequent antibacterial etiotropic therapy resulted in the regression of the neurologic symptoms and remission.
The intravitalpathomorphology study of the brain could be recommended for the management of the severe encephalitis of the unknown origin.
About the Authors
I. A. Voznyuk
Saint-Petersburg Science Research Institute of Emergency Medicine named after I.I. Dzhanelidze
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
E. N. Gnevyshev
3d Military Hospital
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
L. S. Onishchenko
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
O. N. Gaykova
Institute of Toxicology
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
I. V. Nuralova
The State Science Research Institute of Military Medicine
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
I. N. Samartsev
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
I. D. Poltavskiy
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. Yu. Lizunov
Military Medical Academy named after S.M. Kirov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
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Review
For citations:
Voznyuk I.A., Gnevyshev E.N., Onishchenko L.S., Gaykova O.N., Nuralova I.V., Samartsev I.N., Poltavskiy I.D., Lizunov V.Yu. Brain biopsy for diagnosis of chlamydia encephalitis. Journal Infectology. 2017;9(2):121-128. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-2-121-128
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