Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism
https://doi.org/10.22625/2072-6732-2017-9-2-13-16
Abstract
In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting.
About the Authors
N. A. Stepanova
Astrakhan State Medical University
Russian Federation
Astrakhan
Russian Federation
Astrakhan
Kh. M. Galimzyanov
Astrakhan State Medical University
Russian Federation
Astrakhan
Russian Federation
Astrakhan
B. I. Kantemirova
Astrakhan State Medical University
Russian Federation
Astrakhan
Russian Federation
Astrakhan
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Review
For citations:
Stepanova N.A., Galimzyanov Kh.M., Kantemirova B.I. Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism. Journal Infectology. 2017;9(2):13-16. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-2-13-16
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