Interferon-γ: biological function and application for study of cellular immune response
https://doi.org/10.22625/2072-6732-2015-7-4-10-22
Abstract
Cellular immune response plays a central role in control of intracellular pathogens like viruses, some bacteria and parasites. Evaluation of presence, specificity and strength of cellular immune response can be done by investigation of reaction of immune cells to specific stimulus, like antigen. The major cellular reactions to antigen stimulation are production of cytokines, proliferation and cytotoxicity. This review is focused on interferon-gamma as one of the central Th1 cytokines: its biology, immunological role and application as marker of cellular immune response.
About the Authors
A. A. Lutckii
Science Research Institute of Children’s Infection, Saint-Petersburg, Russia
Russian Federation
Russian Federation
A. A. Zhirkov
Science Research Institute of Children’s Infection, Saint-Petersburg, Russia
Russian Federation
Russian Federation
D. Yu. Lobzin
Military Medical Academy named after S.M. Kirov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
M. Rao
Division of Therapeutic Immunology (TIM), LABMED, Karolinska Institutet, Stockholm, Sweden
Russian Federation
Russian Federation
L. A. Alekseeva
Science Research Institute of Children’s Infection, Saint-Petersburg, Russia
Russian Federation
Russian Federation
M. Maeurer
Division of Therapeutic Immunology (TIM), LABMED, Karolinska Institutet, Stockholm, Sweden
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
CAST, Karolinska University Hospital, Stockholm, Sweden
Russian Federation
Russian Federation
Yu. V. Lobzin
Science Research Institute of Children’s Infection, Saint-Petersburg, Russia
Russian Federation
Russian Federation
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Review
For citations:
Lutckii A.A., Zhirkov A.A., Lobzin D.Yu., Rao M., Alekseeva L.A., Maeurer M., Lobzin Yu.V. Interferon-γ: biological function and application for study of cellular immune response. Journal Infectology. 2015;7(4):10-22. (In Russ.) https://doi.org/10.22625/2072-6732-2015-7-4-10-22
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