Features state of hemostasis and immunopathological reactions in epstein-barr virus infection in children
https://doi.org/10.22625/2072-6732-2015-7-2-75-82
Abstract
The results of clinical laboratory analysis conducted in 64 children with Epstein-Barr virus mononucleosis during the acute period and in different time follow-up observations are presents. It is shown that EBV-mononucleosis in children is accompanied by distinct changes of hemostasis, the Genesis of which play some role virusinduced autoimmune mechanisms, developing on the background of hyperactively immune system. The revealed correlation of data breaches with the severity of the infectious process. It was found that the criterion prolongation hemostatic changes are persistent viral activity. Interferon therapy in complex treatment of children, the sick EBV-mononucleosis, contributed to a more rapid regression of a number of clinical symptoms of disease and normalization gemostaziologicheskikh of indicators. Recommended expansion of the research program of follow-up of persons with EBV infection.
About the Authors
S. A. Hmilevskaya
Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia
Russian Federation
Russian Federation
I. A. Zaitseva
Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia
Russian Federation
Russian Federation
N. I. Zryachkin
Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia
Russian Federation
Russian Federation
I. A. Berezhnova
Regional Сlinical Нospital, Saratov, Russia
Russian Federation
Russian Federation
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Review
For citations:
Hmilevskaya S.A., Zaitseva I.A., Zryachkin N.I., Berezhnova I.A. Features state of hemostasis and immunopathological reactions in epstein-barr virus infection in children. Journal Infectology. 2015;7(2):75-82. (In Russ.) https://doi.org/10.22625/2072-6732-2015-7-2-75-82
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