Chronic viral hepatitis B and C in patients with tuberculosis: the proportion of nozoform, dynamic changes
https://doi.org/10.22625/2072-6732-2015-7-2-47-53
Abstract
the purpose of the study. identify the epidemiological of chronic hepatitis B and C, especially in the general population and in patients with different clinical forms of tuberculosis for the period of 2008–2010, treated in the regional clinical TB dispensary Kirov; correlate these data with the frequency of detection of HBV markers and HCVinfections in donors as conditionally healthy population in the region.
Materials and methods. A total of 6959 patients Kirov TB dispensaries in the age range 18–70 years. All patients were screened for markers of viral hepatitis C and B (anti-HCV and HBSAg ELISA). Of them, 537 (7,72%) patients with different forms of tuberculosis were diagnosed with chronic hepatitis B, C, or B + C. The diagnosis of chronic hepatitis B or C based on clinical and anamnestic data, the results of EGD, abdominal ultrasonography. The comparison group included 13,222 primary donors of 6 areas of the Kirov region is also examined for the presence of markers of viral hepatitis B and C for the period 2008–2011 Determination of HBsAg, anti-HBs, anti-HBc anti-HCV were determined by solid-phase ELISA; study of the epidemiological situation of chronic hepatitis B and C are carried out on the basis of the Center for Hygiene and Epidemiology in the Russian Federation and the Kirov region for the 1998–2013 biennium. (Form No 2).
Results and conclusions. The study showed a trend toward stable growth on the incidence of HCV, a slight decrease in the incidence of chronic hepatitis B and a consistently high level of registration of patients with pulmonary tuberculosis, including smear-positive pulmonary forms in the general population of the region. CHC is prevalent among nosology chronic hepatitis in KO (77,2%). CHC also prevailed in the structure of morbidity in patients with tuberculosis as well as in the general population; CHB met in 2–2,8 times less compared to CHC (p <0,05). The tendency to increase the number of TB patients and mixed-hepatitis B + C. The incidence of chronic hepatitis B, C and mixed infection in the total group of patients with various forms of tuberculosis for 3 years was 7,72%, which is 10,2 times higher than in blood donors.
References
1. VOZ. Tuberkuljoz. Informacionnyj bjulleten’ VOZ, No 104, Zheneva: VOZ; 2014.
2. VOZ. Gepatit V. Informacionnyj bjulleten’ VOZ, No 204, Zheneva: VOZ; 2014.
3. VOZ. Gepatit S. Informacionnyj bjulleten’ VOZ, No 164, Zheneva: VOZ; 2014.
4. Aghaa A.M., El-Mahalawya I. I., Seleemb H.M. et all. Prevalence of hepatitis C virus in patients with tuberculosis and its impact in the incidence of anti-tuberculosis drugs induced hepatotoxicity. Egyptian J. of Chest Diseases and Tuberculosis. 2015; (Vol. 64): 91–96.
5. Nazarov V.Ju. Virusnye gepatity i tuberkulez kak sochetannye infekcii. Ot proshlogo k nastojashhemu i budushhemu./ Nazarov V.Ju., Nechaev V.V., Ivanov A.K. i dr.//Zhurnal infektologii. – 2013. -T. 5. – No2. – S.90-95.
6. Petrenko T.I. Tuberkuljoz ljogkih v sochetanii s hronicheskimi virusnymi gepatitami: diagnostika, lechenie, prognoz.: avtoref.diss...dokt. med.nauk./ Petrenko T.I., Novosibirsk: 2008. – s. 43.
7. Rospotrebnadzor po Kirovskoj oblasti i RF. http: // www. 43. rospotrebnadzor.ru i http://rospotrebnadzor.ru (data dostupa 25.03.15)
8. Shkarin V.V. Osnovy retrospektivnogo analiza infekcionnoj zabolevaemosti./ Potehina N.N. [i dr.]; pod red. Shkarina V.V., Rahmanova R.S. – N. Novgoroda: Izd. NGMA, 2009 – 160 s.
9. Os’kin D.N. Sravnitel’naja harakteristika kachestva zhizni pacientov s izolirovannym tuberkulezom organov dyhanija i s tuberkulezom, sochetannym s hronicheskimi gepatitami. / Os’kin D.N., Dobin V.L.// Prakticheskaja medicina.2012.No 56.S. 96-99.
10. Potter J.L., Babiker Z.O., Kunst H. Should patients with active tuberculosis be routinely screened for chronic viral hepatitis? ERJ. 2014; (Vol. 44):3059
11. Mishin V.Ju. Jeffektivnost’ lechenija tuberkuleza legkih, vyzvannogo: mikobakterijami s mnozhestvennoj lekarstvennoj ustojchivost’ju/ Mishin V.Ju., Chukanov V.I., Vasil’eva I.A.// Problemy tuberkuleza. – 2002. – No12. -S. 18-231.
12. Mishin V.Ju. Pobochnoe dejstvie protivotuberkuljoznyh preparatov pri standartnyh i individualizirovannyh rezhimah himioterapii./ Mishin V.Ju., Chukanov V.I., Grigor’ev Ju.G.M: Medicina, 2004. – 207 s.
13. Chien J.Y., Huang R.M., Wang J.Y. et al. Hepatitis C virus infection increases hepatitis risk during anti-tuberculosis treatment. Int. J. Tuberc. Lung Dis. 2010; 14 (5): 616–621
14. Beljanina A. V. Gepatoprotektornaja i antioksidantnaja terapija bol’nyh tuberkuljozom legkih s virusnym i lekarstvennym porazheniem pecheni.: avtoref.diss. kand. med.nauk. / Beljanina A.V. – S-Pb: 2009. – 39 s.
15. Enaleeva D.Sh. Sovremennye aspekty estestvennogo techenija hronicheskogo virusnogo gepatita V./Kazanskij med. zhurnal.2012.No2.tom HSIII.S.161-166.
Review
For citations:
Baramzina S.V. Chronic viral hepatitis B and C in patients with tuberculosis: the proportion of nozoform, dynamic changes. Journal Infectology. 2015;7(2):47-53. (In Russ.) https://doi.org/10.22625/2072-6732-2015-7-2-47-53
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