Influenza pathogenesis: mechanisms of modulation by agent proteins
https://doi.org/10.22625/2072-6732-2015-7-2-31-46
Abstract
Modern concepts of the influence of the proteins from viruses-etiological agents of flu – Influenzavirus A, B and C (Orthomyxoviridae) – on the development of different elements of the main disease pathogenesis are analyzed in the review. In particular, the short description of life cycle of Influenza viruses is alleguered with special attention to those its stages which are capable to modulate pathogenetic mechanisms. The interrelation between the structure of hemagglutinin receptor-binding site and virus tropism as well as the influence of the receptor-destroying virus proteins on this phenomenon is described. The mechanism of suppression of interferon production in the infected cell by virus NS1 protein is presented. The induction of apoptosis by nonstructural PB1-F2 protein of Influenza A virusis described.
About the Authors
M. Yu. Shchelkanov
Pacific State Medical University, Vladivostok, Russia
Hygienic and Epidemiological Center in Primorsky krai, Vladivostok, Russia
Russian Federation
Russian Federation
A. F. Popov
Pacific State Medical University, Vladivostok, Russia
Russian Federation
Russian Federation
A. I. Simakova
Pacific State Medical University, Vladivostok, Russia
Russian Federation
Russian Federation
I. V. Zenin
Pacific State Medical University, Vladivostok, Russia
Russian Federation
Russian Federation
E. S. Proshina
Federal Scientific Research Center for Epidemiology and Microbiology named after N.F. Gamaleya, Moscow, Russia
Russian Federation
Russian Federation
I. M. Kirillov
Federal Scientific Research Center for Epidemiology and Microbiology named after N.F. Gamaleya, Moscow, Russia
Russian Federation
Russian Federation
K. A. Dmitrenko
Pacific State Medical University, Vladivostok, Russia
Russian Federation
Russian Federation
D. V. Shevchuk
Pacific State Medical University, Vladivostok, Russia
Russian Federation
Russian Federation
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For citations:
Shchelkanov M.Yu., Popov A.F., Simakova A.I., Zenin I.V., Proshina E.S., Kirillov I.M., Dmitrenko K.A., Shevchuk D.V. Influenza pathogenesis: mechanisms of modulation by agent proteins. Journal Infectology. 2015;7(2):31-46. (In Russ.) https://doi.org/10.22625/2072-6732-2015-7-2-31-46
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