Genetic diversity of penicillin-resistant Streptococcus pneumoniae
https://doi.org/10.22625/2072-6732-2009-1-4-66-71
Abstract
Fifty five Streptococcus pneumoniae isolates with reduced susceptibility to penicillin, obtained from patients with respiratory tract infections during 2003 –2007, were analyzed by MLST. Ten isolates were identified by MLST as Streptococcus «viridians» group. Among the remaining isolates 33,3% (n=15) belonged to global clonal complex CC81 and demonstrated reduced susceptibility to macrolides, tetracyclynes and chloramphenicol, three isolates were additionally resistant to levofloxacin. Clonal complex CC271 was represented by 5 isolated (11,1%), CC315 – by 4 (8,9%), CC315 – by 3 (6,7%), CC156, CC280 and CC1012 were represented by 2 (4,4%) isolates each. Isolates of clonal complexes 271 and 315 demonstrated high level of associated resistance to macrolides. Twelve clonal complexes were represented by single isolates. More than 50% of isolates with reduced susceptibility to penicillin belonged to three global clonal complexes. Probably these clonal complexes were imported to Russia from other geographical regions.
About the Authors
T. A. Savinova
Research Center of Medical Agents Evaluation, Moscow
Russian Federation
Russian Federation
O. Y. Filimonova
Russian Medical Academy of Post-Graduate Education, Moscow
Russian Federation
Russian Federation
S. A. Grudinina
Federal Antibiotic Research Center, Moscow
Russian Federation
Russian Federation
S. V. Sidorenko
Research Institute of Children’s Infections, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Savinova T.A., Filimonova O.Y., Grudinina S.A., Sidorenko S.V. Genetic diversity of penicillin-resistant Streptococcus pneumoniae. Journal Infectology. 2009;1(4):66-71. (In Russ.) https://doi.org/10.22625/2072-6732-2009-1-4-66-71
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