Problems and opportunities for complex treatment of ARVI and other viral infections in children in outpatient practice. Assessing the value of antiviral and local therapy (Resolution of the interdisciplinary Council of Experts)
https://doi.org/10.22625/2072-6732-2025-17-4-181-190
Abstract
In September 2025, a meeting of experts was convened to discuss the problems of modern viral diseases, which are widespread and economically significant. Pathogens capable of causing respiratory tract damage belong to various taxonomic groups and manifest not only with the primary syndrome (respiratory inflammatory syndrome) but also with other diverse lesions of human systems and organs. The council was held in an interdisciplinary format and featured leading experts in pediatrics, infectious diseases, allergology, immunology, dermatology, and pharmacology. Given the significance of viral infections in children and adolescents, several key issues related to improving medical care for this category of patients were discussed. The purpose of the Expert Council was to systematize the available data on the treatment of viral infections affecting the respiratory tract and to exchange clinical experience in the management of pediatric patients (antiviral and immunomodulatory). The use of the drug inosine pranobex by the council members for various viral diseases and the relief of syndromes caused by the lymphoproliferative capabilities of viruses has made it possible to shorten the duration of the disease, its chronicity, reduce the need for antibiotic therapy and the development of complications. Among the effective medications with antiviral and immunostimulatory activity, inosine pranobex is a popular choice. Its active ingredient is inosine pranobex. Its pharmacotherapeutic group is immunostimulant. Its primary pharmacological actions are immunostimulatory and antiviral. Its mechanism of action is primarily the suppression of viral DNA and RNA replication.
Respiratory viral infections remain a significant public health threat, especially to pediatric patients, requiring optimized diagnostic, treatment, and prevention efforts. Prescribing inosine pranobex reduces the recurrence rate of respiratory infections, herpesvirus infections, and other viral diseases, shortens the intensity and duration of acute respiratory viral infections, and improves overall patient well-being.
About the Authors
M. S. SavenkovaRussian Federation
Moscow
E. V. Esaulenko
Russian Federation
Saint-Petersburg
V. A. Petrov
Russian Federation
Obninsk
N. B. Migacheva
Russian Federation
Samara
N. A. Abramova
Russian Federation
Moscow
Yа. A. Bogvilene
Russian Federation
Krasnoyarsk
S. V. Khaliullina
Russian Federation
Kazan
R. A. Ushakova
Russian Federation
Ekaterinburg
G. M. Filippova
Russian Federation
Barnaul
E. V. Dudnikova
Russian Federation
Rostov-on-Don
A. P. Ivanova
Russian Federation
Kursk
O. R. Varnikova
Russian Federation
Ivanovo
N. S. Tataurshchikova
Russian Federation
Moscow
V. G. Yankova
Russian Federation
Moscow
K. E. Novak
Russian Federation
Saint-Petersburg
A. D. Ibrokhimova
Russian Federation
Saint-Petersburg
M. G. Pozdnyakova
Russian Federation
Saint-Petersburg
References
1. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2024 godu: Gosudarstvennyy doklad. M.: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka. – 2025. – 424s.
2. Il’icheva T.N. COVID-19, gripp i drugie ostrye respiratornye virusnye infektsii: etiologiya, immunopatogenez, diagnostika i lechenie. Chast’ I. COVID-19 i gripp / T.N. Il’icheva, S.V. Netesov, V.N. Gureev // Molekulyarnaya genetika, mikrobiologiya i virusologiya. – 2022. – T. 40, №1. – S. 3–11.
3. Gorelov A.V. Virusnye pnevmonii: epidemiologiya, diagnostika, terapiya, profilaktika / A.V. Gorelov, S.N. Avdeev, E.V. Esaulenko, A.G. Malyavin i dr. // Izdatel’stvo “Media Sfera”. – 2024. – 220 s.
4. Popova O.P. Klinicheskie osobennosti techeniya rinovirusnoy infektsii u detey / O.P. Popova, R.V. Vartyanyan, S.V. Trushakova, S.V. Bunin, N.A. Dracheva // Zh. Detskie infektsii. – 2021. – T. 20, №2. – S.16–21.
5. Korsun N. Etiological Spectrumof Acute Respiratory Infections in Bulgaria During the 2023–2024 Season and Genetic Diversity of Circulating Influenza Viruses / N. Korsun, I. Trifonova, D. Pavlova, Y. Uzunova, I. Ivanov, D. Ivanov et al. // Viruses. – 2025. – V. 17. – R. 270.
6. Horemheb-Rubio G., Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe / G. Horemheb-Rubio, R. Eggeling, N. Schmeiβer et al. // BMC Public Health. – 2022. – V. 22. – P. 1167.
7. Babachenko I.V. Effektivnost’ inozina pranobeksa v lechenii i profilaktike infektsionnykh zabolevaniy (Sistematicheskiy obzor) / I.V. Babachenko // Zh. Infektologii. – 2023. – T 15, №4. – S. 42–53.
8. Esaulenko E.V. Sovremennye aspekty terapii ostrykh respiratornykh virusnykh infektsiy (sistematicheskiy obzor) / E.V. Esaulenko, A.D. Ibrokhimova, M.G. Pozdnyakova, K.E. Novak // Zh. Infektologii. – 2024. – T. 16, № 4. – S. 23–31.
9. Savenkov M.P. Analiz mnogotsentrovykh programm po otsenke effektivnosti terapii ORVI u detey v ambulatorno-poliklinicheskoy praktike za period 2019–2025 gg. v Rossiyskoy Federatsii. / M.P. Savenkov // RMZh. Mat’ i ditya. – 2025. – T. 8, №3. – S. 258–262.
10. El-Azami-El-Idrissi M. Pediatric recurrent respiratory tract infections: when and how to explore the immune system? (About 53 cases) / M. El-Azami-El-Idrissi, M. Lakhdar-Idrissi, S. Chaouki, S. Atmani, A. Bouharrou, M. Hida // Pan Afr Med J. – 2016. – V. 24. – P. 53.
11. Chebotareva T.A. Osobennosti immuniteta chasto boleyushchikh detey: immunodefitsit ili tranzitornye narusheniya? / T.A. Chebotareva, S.K. Karyaeva, V.V. Malinovskaya, L.N. Mazankova, O.V. Parshina, T.S. Guseva, V.V. Lazarev, A.G. Khokhoeva // Rossiyskiy vestnik perinatologii i pediatrii. – 2010. – T. 55, № 4. – S. 70–74.
12. Savenkova M.S. Znachenie protivovirusnoy terapii pri respiratornykh infektsiyakh u detey: analiz kliniko-laboratornogo nablyudeniya / M.S. Savenkova, E.I. Isaeva, E.N. Vetrova, G.N. Kraseva, N.A. Abramova, M.B. Shabad, R.V. Dushkin, S. Fadeeva, S.V. Kontio, M.P. Savenkov // Voprosy prakticheskoy pediatrii. – 2022. – T. 17, №6. – S. 48–54.
13. Ruzhentsova T.A. Gerpesvirusnye infektsii v formirovanii epizodov ORVI u detey / T.A. Ruzhentsova, R.V. Popova, A.A. Garbuzov, E.K. Shushakova, I.N. Khalyastov, N.A. Meshkova // RMZh. Mat’ i ditya. – 2023. – T. 6, №4. – S. 399–404.
14. Yankova V.G., Gobyzov O.A., Ryabov M.N., Grigor’eva V.Yu., Udyanskaya I.L., Zhukova A.A., Slonskaya T.K., Plahotnaya O.N., Epshtejn N.B., Pomazkina M.P., Gribanova S.V. Kachestvo raspyleniya dozirovannyh spreev: cravnitel’noe issledovanie benzidaminsoderzhashchih preparatov. Voprosy prakticheskoj pediatrii. 2025; 20(5): 39–48.
15. Kuz’mina M.N. Sovremennyy infektsionnyy mononukleoz u detey: rezul’taty sobstvennykh nablyudeniy //M.N. Kuz’mina, S.N. Eshmolov, E.G. Klimovitskaya, I.G. Sitnikov // Patsientoorientirovannaya meditsina i farmatsiya. – 2025. – T. 3, №3. – S.77–85.
16. Mikhneva S.A. Infektsionnyy mononukleoz: kharakteristika proyavleniy epidemicheskogo protsessa / S.A. Mikhneva, Yu.Yu. Grishina, E.V. Kukhtevich, Martynov Yu.V. // Infektsionnye bolezni: novosti, mneniya, obuchenie. – 2017. – № 5. – S. 61–64.
17. Kawa K. Epstein-Barr virus-associated diseases in humans / K. Kawa // Inf. J. Hematol. – 2000. – V. 71. – P. 108–117.
18. Savenkova M.S. Experience of treatment with Groprinosin (inosine pranobex) for herpes virus infection in children with epilepsy and infantile cerebral palsy / M.S. Savenkova, G.M. Balakireva, E.S. Kuznetsova et al. // Pediatrics. Consilium Medicum. – 2019. – V. 4. – R. 51–57.
19. Naumova A.S. Differentsial’naya diagnostika limfadenopatiy u detey / A.S. Naumova, O.A. Tiganova, L.I. Il’enko // Pediatriya. Consilium Medicum. – 2019. – T. 2. – S. 32–38.
20. Healy C. M. Cervical lymphadenitis in children: Diagnostic approach and initial management. [Internet]. [sited 12.02.2022].Available from: https://www.uptodate.com.
21. McClain K. L. Peripheral lymphadenopathy in children: Evaluation and diagnostic approach. [Internet]. [cited 20.02.2022].Available from: https://www.uptodate.com.
22. Savenkova M.S. Znachenie gerpesvirusov v postkovidnom periode u detey / M.S. Savenkova, I.A. Sotnikov, A.A. Afanas’eva i dr. // RMZh. Mat’ i ditya. – 2023. – T.6, №1. – S. 39–44.
23. Mareri A. Herpesvirus-Associated Acute Urticaria: An Age Matched Case-Control Study / A. Mareri, S.P. Adler, G. Nigro // PLoS ONE. – 2013. – V. 8, №12. – e85378.
24. Zawar V. Chronic urticaria associated with recurrent genital herpes simplex infection andsuccess of antiviral therapy: A report of two cases / V. Zawar, K. Godse, S. Sankalecha // Int J InfectDis14. – 2010. – e514–e517.
25. Tamrazova O.B. Klinicheskie proyavleniya infektsii prostogo ger¬pesa u detey, stradayushchikh atopicheskim dermatitom / O.B. Tamrazova, T.A. Chebotareva, A.S. Stadnikova, A.V. Taganov // Ros. vestnik perinatologii i pediatrii. – 2018. – T. 63,№6. – S.15–22.
26. Letyaeva O.I. Rol’ infektsionnykh agentov v patogeneze dermatozov u detey i podrostkov / O.I. Letyaeva // Zh. Detskie infektsii. – 2020. – T.19, №3. – S.58–64.
27. Vakhitov Kh. M. Gerpetiformnaya ekzema Kaposhi u rebenka pervogo goda zhizni / Kh. M. Vakhitov, A.G. Makhmutova, L.M. Ziyatdinova, M.S. Pospelov // Kazanskiy meditsinskiy zhurnal. – 2020. – T. 101, №. 3. – S. 426–430.
28. Ludman S.W. Increased complications with atopic dermatitis and varicella-zoster virus / S.W. Ludman, A.M. Powell, E.M.E. MacMahon, N. Martinez-Alier, G. Du Toit // Current Allergy and Clinical Immunology. – 2014. – V. 27, №2. – P.108–111.
29. Demina O. I. Klinicheskie proyavleniya infektsionnogo mononukleoza pri pervichnoy ili reaktivirovannoy gerpesvirusnoy infektsii / O. I. Demina, T. A. Chebotareva, L. N. Mazankova, V. B. Tetova, O. N. Uchaeva // Zh. Rossiyskiy vestnik perinatologii i pediatrii. – 2020. – T. 65, №1. – S. 37–44.
30. Golitsyna L.N. Zabolevaemost’, etiologicheskaya struktura i voprosy profilaktiki enterovirusnoy (nepolio) infektsii / L.N. Golitsyna, S.G. Selivanova, V.V. Zverev // Informatsionnyy byulleten’. Referens-tsentr po monitoringu za enterovirusnymi infektsiyami. FBUN NNIIEM im. akademika I.N. Blokhinoy Rospotrebnadzora. – 2025. – 39s.
31. Pis’mo Federal’noy sluzhby po nadzoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka ot 18 iyunya 2025 g. N 02/11390-2025-27 “Ob epidemiologicheskoy situatsii po enterovirusnoy infektsii”, elektronnyy dostup https://base.garant.ru/412378160/, data obrashcheniya 28.11.25
32. Levin D. Yu. Otsenka efektivnosti izoprinazina pri enterovtrusnoy infektsii u detey / D. Yu. Levin, E. S. Balabanova, U. A. Udalova // BMIK. – 2019. – №3. – S. 134.
33. Forma federal’nogo statisticheskogo nablyudeniya №2 «Svedeniya ob infektsionnykh i parazitarnykh zabolevaniyakh» za 2024 god.
34. WHO. Press release. [Internet]. [sited 13.03.2025]. Available from: https://www.who.int/europe/ru/news/item/13-03-2025-european-region-reports-highest-number-ofmeasles-cases-in-more-than-25-years---unicef--who-europe
35. Rymarenko N.V. Kor’: osobennosti immunnogo otveta i vozmozhnosti terapii na sovremennom etape / N.V. Rymarenko, E.A. Kryuger //Pediatriya. – 2018. – T. 97, №3. – S. 69–74.
Review
For citations:
Savenkova M.S., Esaulenko E.V., Petrov V.A., Migacheva N.B., Abramova N.A., Bogvilene Y.A., Khaliullina S.V., Ushakova R.A., Filippova G.M., Dudnikova E.V., Ivanova A.P., Varnikova O.R., Tataurshchikova N.S., Yankova V.G., Novak K.E., Ibrokhimova A.D., Pozdnyakova M.G. Problems and opportunities for complex treatment of ARVI and other viral infections in children in outpatient practice. Assessing the value of antiviral and local therapy (Resolution of the interdisciplinary Council of Experts). Journal Infectology. 2025;17(4):181-190. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-4-181-190



















































.png)
.png)

