Genotypic diversity of HIV-1 and hepatitis C virus among persons with newly diagnosed HIV infection in Uzbekistan
https://doi.org/10.22625/2072-6732-2025-17-4-88-92
Abstract
Objective: To study the molecular genetic features of HIV-1 and HCV coinfection in antiretroviral-naive patients, assessing the distribution of genotypes of both viruses.
Materials and methods: a total of 288 blood plasma samples collected in 2024 at the Republican AIDS Center from all regions of Uzbekistan were analyzed.
Results: the obtained study data demonstrated a high prevalence of active replication of the hepatitis C virus among patients with newly diagnosed HIV infection who are not receiving antiretroviral therapy. Genetic diversity was established both among HIV-1 strains (subtypes A6 and CRF_02AG were identified) and among HCV genotypes (dominance of genotypes 3a and 1b), which reflects the characteristics of the epidemic process in the region.
Conclusion: The results of the study highlight the need for routine molecular testing and genotyping of both viruses before starting ART for timely diagnosis, selection of optimal therapy and effective epidemiological surveillance.
About the Authors
E. I. Musabaev
Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases
Uzbekistan
Uzbekistan
Tashkent
E. I. Kazakova
Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases
Uzbekistan
Uzbekistan
Tashkent
N. S. Ibadullaeva
Research Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases
Uzbekistan
Uzbekistan
Tashkent
T.-M. K. Yuldashev
Republican AIDS Center
Uzbekistan
Uzbekistan
Tashkent
V. Sh. Rakhimova
Center for Professional Development of Medical Workers
Uzbekistan
Uzbekistan
Tashkent
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Review
For citations:
Musabaev E.I., Kazakova E.I., Ibadullaeva N.S., Yuldashev T.K., Rakhimova V.Sh. Genotypic diversity of HIV-1 and hepatitis C virus among persons with newly diagnosed HIV infection in Uzbekistan. Journal Infectology. 2025;17(4):88-92. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-4-88-92
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