Association of rs 9939609 polymorphism of the FTO gene with the development of obesity and type 2 diabetes mellitus in patients with chronic hepatitis C
https://doi.org/10.22625/2072-6732-2025-17-4-67-72
Abstract
Currently, an urgent problem in clinical medicine is the comorbid course of diseases. Their prevention and treatment are designated by WHO as a priority project of the 21st century. Comorbidity among patients with HCV infection is of particular interest. Its frequency is about 63% and one of the reasons for the development of comorbid pathology is genetic.
Оbjective To identify the role of rs9939609 FTO gene polymorphism in the development of obesity and type 2 diabetes mellitus in patients with chronic hepatitis C.
Materials and methods. 201 patients participated in the study. During the study, the patients were divided into two groups: the main group consisted of 101 patients with chronic hepatitis C, obesity (BMI ≥ 30 kg/m2), and type 2 diabetes; the comparison group consisted of 100 patients with chronic hepatitis C without obesity (BMI <30 kg/m2) and type 2 diabetes. The diagnosis of chronic HCV infection was based on the identification of specific markers. A genetic analysis of the DNA of patients living in Yaroslavl was carried out. Genomic DNA was isolated from venous blood. The polymorphism of the FTO (A23525T) gene was tested using real-time PCR on an iCycler iQ5 (BioRad) device with a set of SNP-express-RV reagents.
Results. When analyzing the frequency distribution of alleles and genotypes of the FTO gene in patients with chronic hepatitis C and in the comparison group (patients with HCV without MS), statistically significant differences were found. It has been found that the carriage of the T allele, TT and AT genotypes of the FTO gene is more common in individuals with chronic hepatitis C and type 2 diabetes mellitus, and obesity (RR=1.06; 1.19; 0.05, respectively, p<0.05). Carriage of TT genotypes of the FTO gene is significantly associated with the development of type 2 diabetes mellitus in individuals with chronic hepatitis C (RR=3.1; p <0.05).
Conclusion. Thus, a study in patients with chronic hepatitis C revealed an association of the rs9939609 polymorphism of the FTO gene with obesity and type 2 diabetes mellitus. According to the results obtained, a link has been established with homozygous TT and heterozygous AT genotype in the development of concomitant comorbid pathology.
About the Authors
A. A. Koklyushkina
Yaroslavl State Medical University
Russian Federation
Russian Federation
Yaroslavl
M. S. Bokhonov
Yaroslavl State Medical University
Russian Federation
Russian Federation
Yaroslavl
I. G. Sitnikov
Yaroslavl State Medical University
Russian Federation
Russian Federation
Yaroslavl
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For citations:
Koklyushkina A.A., Bokhonov M.S., Sitnikov I.G. Association of rs 9939609 polymorphism of the FTO gene with the development of obesity and type 2 diabetes mellitus in patients with chronic hepatitis C. Journal Infectology. 2025;17(4):67-72. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-4-67-72
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