Invincible pertussis: clinical and epidemiological features of pertussis in children at the present stage (based on materials from the Komi Republic)
https://doi.org/10.22625/2072-6732-2025-17-4-58-66
Abstract
Objective: to analyze the clinical and epidemiological features of the course of pertussis infection in children of various age groups taking into account vaccination status. The work is aimed at raising the vigilance of primary care pediatricians, as well as updating approaches to prevention and revaccination.
Materials and Methods: The work presents data of a retrospective analysis of archival medical documentation of children from 0 to 18 years old, hospitalized at the Republican Infectious Diseases Hospital of Syktyvkar, with a confirmed diagnosis of pertussis for the period 2019–23. The diagnosis was verified using a bacteriological method, serological study, and polymerase chain reaction.
Mathematical analysis of the obtained data was carried out using the BioStat version 6 statistical software package (Analyst Soft Inc, USA). For comparison of mean values, the Wilcoxon test was used.
Results. Over the past two decades in the Komi Republic, a stable trend of increasing pertussis incidence has been noted. The greatest epidemiological vulnerability, the highest level of incidence, was demonstrated by children in the first year of life. Age-related incidence peaks were identified among vaccinated children (at ages under 1 year, 6–7 and 11–13 years), which may be associated with waning postvaccination immunity and insufficient vaccination coverage.
Conclusion. The epidemiological reality of the current stage is the trend toward an increase in pertussis incidence even in countries with high vaccination coverage and modern diagnostic methods. The importance of cocoon vaccination against pertussis during pregnancy is substantiated, and the updating of the regional immunization schedule with revaccination against pertussis at 6 and 14 years is actualized.
About the Authors
M. D. Bezdenezhnykh
Syktyvkar State University named after Pitirim Sorokin
Russian Federation
Russian Federation
Syktyvkar
S. K. Delkov
Syktyvkar State University named after Pitirim Sorokin
Russian Federation
Russian Federation
Syktyvkar
T. V. Bezuglaya
Syktyvkar State University named after Pitirim Sorokin;
Republican Infectious Diseases Hospital, Republic of Komi
Russian Federation
Russian Federation
Syktyvkar
N. N. Korableva
Syktyvkar State University named after Pitirim Sorokin
Russian Federation
Russian Federation
Syktyvkar
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Review
For citations:
Bezdenezhnykh M.D., Delkov S.K., Bezuglaya T.V., Korableva N.N. Invincible pertussis: clinical and epidemiological features of pertussis in children at the present stage (based on materials from the Komi Republic). Journal Infectology. 2025;17(4):58-66. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-4-58-66
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