Preview

Journal Infectology

Advanced search

The impact of the COVID-19 pandemic on the epidemiology of whooping cough (review of literature)

https://doi.org/10.22625/2072-6732-2025-17-1-15-25

Abstract

The review presents current information on the epidemiological situation with whooping cough during the COVID-19 pandemic and in the post-pandemic period: the dynamics and age structure of the incidence in different countries of the world are shown with an analysis of the causes of changes. According to the literature, the effect of isolation measures on the incidence of whooping cough in 2023–2024 is described using the example of Japan, as well as vaccination of pregnant women against whooping cough using the example of South Korea. Some aspects of the pathogenesis of whooping cough and COVID-19 are presented, which can affect the course of combined diseases in children. The article presents an analysis of two described clinical cases in unvaccinated children aged 1 and 4 months, showing the dominance of typical clinical manifestations of whooping cough, the absence of fever and intoxication characteristic of COVID-19, the development of bronchiolitis with respiratory failure, which aggravated the severity of the disease. This justifies the advisability of examining patients with whooping cough with atypical respiratory manifestations for a new coronavirus infection, and for whooping cough – COVID-19 convalescents with a long cough.

About the Authors

N. A. Filaeva
Federal Scientific and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg


Competing Interests:

None



I. V. Babachenko
Federal Scientific and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical University
Russian Federation

Saint-Petersburg


Competing Interests:

None



N. N. Kurova
Science Research Institute of Epidemiology and Microbiology named after Pasteur
Russian Federation

Saint-Petersburg


Competing Interests:

None



References

1. O sostoyanii sanitarno-e`pidemiologicheskogo blagopoluchiya naseleniya v Rossijskoj Federacii v 2023 godu: Gosudarstvenny`j doklad. Moskva: Federal`naya sluzhba po nadzoru v sfere zashhity` prav potrebitelej i blagopoluchiya cheloveka, 2024. – 364 (in Russian).

2. Babachenko I.V., Xarit S.M., Kurova N.N., Ceneva G.Ya. Whooping cough in children. M.: Kommentarij, 2014: 176 (in Russian).

3. Kazantsev A.P., Volzhanin V.M. Rukovodstvo po infektsionnym boleznyam / Ye. S. Belozerov, YU. I. Bulan’kov, V. V. Vasil’yev [i dr.]. – Kn. 1. - 4-ye izd., pererab. i dop. – SPb.: OOO “Izdatel’stvo Foliant”, 2011: 554-558 (in Russian).

4. Markey K, Douglas-Bardsley A, Asokanathan C. et al. Improvement in serological diagnosis of pertussis by external quality assessment. J Med Microbiol. 2019 May;68(5):741-747.

5. Burrell R, Saravanos G, Britton PN. Unintended impacts of COVID-19 on the epidemiology and burden of paediatric respiratory infections. Paediatr Respir Rev. 2023 Aug 3:S1526-0542(23)00044-1.

6. Tessier E, Campbell H, Ribeiro S, et al. Impact of the COVID-19 pandemic on Bordetella pertussis infections in England. BMC Public Health. 2022 Feb 28;22(1):405.

7. Hirae K, Hoshina T, Koga H. Impact of the COVID-19 pandemic on the epidemiology of other communicable diseases in Japan. Int J Infect Dis. 2023 Mar;128:265-271.

8. UK Health Security Agency. Research and analysis сonfirmed cases of pertussis in England by month; 2024. [cited 2024 Dec 12]. Available from: https://www.gov.uk/government/publications/pertussis-epidemiology-in-england-2024.

9. Stein-Zamir C, Shoob H, Abramson N, Brown EH and Zimmermann Y (2023). Pertussis outbreak mainly in unvaccinated young children in ultra-orthodox Jewish groups, Jerusalem, Israel 2023. Epidemiology and Infection, 151, e166, 1–6.

10. Linardos G, Coltella L, Ranno S, et al. Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic. Antibiotics. 2024; 13(5):464.

11. European Centre for Disease Prevention and Control. Increase of pertussis cases in the EU/EEA, 8 May 2024. Stockholm: ECDC; 2024. [cite 2024 Dec 12]. Available from: https://www.quotidianosanita.it/allegati/allegato1715164562.pdf.

12. Cho S, Kim DW, Achangwa C, et al. Pertussis in the elderly: Plausible amplifiers of persistent community transmission of pertussis in South Korea. J Infect. 2024 Sep;89(3):106232.

13. Korea Disease Control and Prevention. Infectious disease portal. [cite 2024 Dec 12]. Available from: https://www.kdca.go.kr/board/board.es?mid=a30501000000&bid=0031&list_no=725602&act=view.

14. Hu Y, Wang L, Yao K, Wang Q. Atypical surge of hospitalized and severe cases of pertussis: A single center 19-years study from China. Pulmonology. 2024 Nov-Dec;30(6):636-638.

15. Sun Z, Zhang H, Yang Y, Wan H, Wang Y. Impacts of geographic factors and population density on the COVID-19 spreading under the lockdown policies of China. Sci Total Environ. 2020 Dec 1;746:141347.

16. Mengyang, Guo et al. Resurgence and atypical patterns of pertussis in China. Journal of Infection. 2024; 88 (4): 106140.

17. Liu Y, Ye Q. Resurgence and the shift in the age of peak onset of pertussis in southern China. J Infect. 2024 Aug;89(2):106194.

18. Babachenko I.V. Zhurnal infektologii. 2019; 11, № 2: 88 – 96 (in Russian).

19. Popova, O.P. [i dr.]. Ros vestn perinatol i pediatr. 2021; 66, №5: 82-87 (in Russian).

20. Popova, O.P. [i dr.] Detskie infekcii. 2024; 23, №2: 52-54 (in Russian).

21. Konstantinova. E.Yu. Zhurnal infektologii. 2022; 14, № 5: 109 – 115 (in Russian).

22. Trushakova, S.V. [i dr.] Molekulyarnaya diagnostika i biobezopasnost` 2024: sbornik tezisov Kongressa s mezhdunarodny`m uchastiem (Moskva, 16–17 aprelya 2024 goda) / pod red. akademika RAN V.G. Akimkina. M.: FBUN CzNII E`pidemiologii Rospotrebnadzora, 2024: 118-120 (in Russian).

23. Belyakov N.A., Bagnenko S.F., Rassoxin V.V. [i dr.] Evolution of the COVID-19 pandemic: monograph. SPb., Baltijskij medicinskij obrazovatel`ny`j centr. 2021; 410 (in Russian).

24. Andreenko A. A., Andreychuk Yu. V., Arsentyev V. G. [i dr.] Infection caused by SARS-CoV-2; Military Medical Academy named after S.M. Kirov. – St. Petersburg: Military Medical Academy named after S.M. Kirov, 2023; 48 (in Russian).

25. Fisun A. Ya., Cherkashin D. V., Ty`renko V. V., Zhdanov K. V., Kozlov K. V. Аrterial’naya gipertoniya. 2020; 26, №3: 2248-2262 (in Russian).

26. Yarovaya, G. A., Neshkova A. E. Bioorganicheskaya ximiya. 2015; 41, № 3: 275. (in Russian).

27. Harrison A.G., Lin T., Wang P. Mechanisms of SARS-CoV-2 Transmission and Pathogenesis // Trends in Immunology. Oct 14; 41(12):1100–1115.

28. Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, Mast AE, Justice A, Aronow B, Jacobson D. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Elife. 2020 Jul 7;9:e59177.

29. Hewitt M, Canning BJ. Coughing precipitated by Bordetella pertussis infection. Lung. 2010 Jan;188 Suppl 1:S73-9.

30. Wettstein L, Weil T, Conzelmann C. et al. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV 2 infection. Nat Commun. 2021 Mar 19;12(1):1726.

31. Lietz S, Sommer A, Sokolowski LM et al. Alpha-1 antitrypsin inhibits pertussis toxin. J Biol Chem. 2024 Oct 30;300(12):107950.

32. Okyay RA, Sahin AR, Aguinada RA, Tasdogan AM. Why are Children Less Affected by COVID-19? Could there be an Overlooked Bacterial Co-Infection? EJMO 2020;4(1):104–105.

33. Liniger M, Zuniga A, Tamin A et al. Induction of neutralising antibodies and cellular immune responses against SARS coronavirus by recombinant measles viruses. Vaccine. 2008; 26: 2164-74.

34. Salas J, Morley JE, Hoft DF, Scherrer JF. Lower risk for COVID-19 hospitalization among patients in the United States with past vaccinations for herpes zoster and tetanus, diphtheria and pertussis. Prev Med Rep. 2023 Jun 25;35:102302.

35. Zhang Y, Ran Z, Tian M, et al. Commensal microbes affect host humoral immunity to Bordetella pertussis infection. Infection and immunity 2019;87:e00421-19.

36. Berry I, Cole M, Silk B, et al. SARS-Cov-2 coinfections among pertussis cases identified through the Enhaced Pertussis Surveillance system in the United States, January 2020 – February 2023. PLoS ONE 19(12): e0311488. https://doi.org/10.1371/journal.pone.0311488


Review

For citations:


Filaeva N.A., Babachenko I.V., Kurova N.N. The impact of the COVID-19 pandemic on the epidemiology of whooping cough (review of literature). Journal Infectology. 2025;17(1):15-25. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-1-15-25

Views: 238


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-6732 (Print)