A clinical case of disseminated BCG infection with a fatal outcome
https://doi.org/10.22625/2072-6732-2024-16-1-94-103
Abstract
Complications after the introduction of the tuberculosis vaccine develop extremely rarely. They become accidentally vaccinated infants with undiagnosed severe immunodeficiency. The article considers a clinical case of the course of disseminated BCG infection with multiple organ damage in congenital immunodeficiency in a 9-month-old boy. The disease manifested itself acutely, the child’s condition worsened within a week, and its outcome was the death of the baby. Primary immunodeficiency was confirmed by the results of a pathoanatomic examination. The discussion provides a classification of complications after the introduction of BCG vaccine, the algorithm of the doctor’s actions in case of a suspected complication after vaccination, and also describes the main signs of immunodeficiency.
About the Authors
S. M. Kharit
Pediatric Research and Clinical Center for Infectious Disease;
Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Saint-Petersburg
Yu. E. Konstantinova
Pediatric Research and Clinical Center for Infectious Disease
Russian Federation
Russian Federation
Saint-Petersburg
V. E. Karev
Pediatric Research and Clinical Center for Infectious Disease
Russian Federation
Russian Federation
Saint-Petersburg
I. A. Karabak
Pediatric Research and Clinical Center for Infectious Disease
Russian Federation
Russian Federation
Saint-Petersburg
A. I. Konev
Pediatric Research and Clinical Center for Infectious Disease
Russian Federation
Russian Federation
Saint-Petersburg
K. K. Tikhomirova
Pediatric Research and Clinical Center for Infectious Disease
Russian Federation
Russian Federation
Saint-Petersburg
M. E. Lozovskaja
Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Saint-Petersburg
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Review
For citations:
Kharit S.M., Konstantinova Yu.E., Karev V.E., Karabak I.A., Konev A.I., Tikhomirova K.K., Lozovskaja M.E. A clinical case of disseminated BCG infection with a fatal outcome. Journal Infectology. 2024;16(1):94-103. (In Russ.) https://doi.org/10.22625/2072-6732-2024-16-1-94-103
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