Humoral immunity to new coronavirus infection and vitamin D level in healthcare workers
https://doi.org/10.22625/2072-6732-2023-15-2-93-104
Abstract
Aim: to assess the dynamic changes of humoral immune responses against the S-protein of SARS-CoV-2 and vitamin D level in healthcare workers providing care to COVID-19 patients.
Methods. Repeated cross-sectional studies were conducted with an interval of 6 months (May-December 2021) including 170 healthcare workers of infectious settings. An enzyme linked immunosorbent assay was used for the quantitative detection of immunoglobulins G to SARS-CoV-2 and the vitamin D level in the blood serum.
Results. In 1.5 years after the start of the pandemic, 91.2% healthcare workers were seropositive to SARS-Co-V-2. In December 2021, this proportion became 98.8%, and the percentage of individuals with high antibodies level (>150 BAU / ml) raised from 49.4% to 77%. Increase in antibodies level induced by vaccination against SARS-CoV-2 was significantly higher in those who have had prior COVID-19 (1031 BAU/мл) compared to those previously vaccinated (367 BAU/ml). The vitamin D level was lower than reference values in 71.2% of health workers and did not correlate with the concentration of antibodies to SARS-Co-V-2.
Conclusion. SARS-Co-V-2 seroprevalence among healthcare workers reached almost 100% by the end of the second year of the pandemic. A greater increase in antibodies level after vaccination was observed in healthcare workers previously infected with SARS-Co-V-2 due to formation of hybrid immunity. We did not reveal the association between the vitamin D level and the humoral immune response to SARS-Co-V-2.
About the Authors
E. A. Krieger
Northern State Medical University
Russian Federation
Russian Federation
Arkhangelsk
O. V. Samodova
Northern State Medical University
Russian Federation
Russian Federation
Arkhangelsk
I. V. Schepina
Northern State Medical University; Arkhangelsk Regional Clinical Hospital
Russian Federation
Russian Federation
Arkhangelsk
L. L. Shagrov
Northern State Medical University
Russian Federation
Russian Federation
Arkhangelsk
Yu. M. Zvezdina
Northern State Medical University
Russian Federation
Russian Federation
Arkhangelsk
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For citations:
Krieger E.A., Samodova O.V., Schepina I.V., Shagrov L.L., Zvezdina Yu.M. Humoral immunity to new coronavirus infection and vitamin D level in healthcare workers. Journal Infectology. 2023;15(2):93-104. (In Russ.) https://doi.org/10.22625/2072-6732-2023-15-2-93-104
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