Case of lethal outcome of an infant due to COVID-19
https://doi.org/10.22625/2072-6732-2021-13-2-142-148
Abstract
The article presents clinical data and the results of a detailed pathology changes in a 2-month-old infant who died from a coronavirus infection, confirmed by the results of in vivo PCR and morphological examination, which included the detection of the SARS-Cov-2 spike antigen. Histological examination in the lungs, as well as in the brain revealed cytoproliferative and cytopathic changes similar to those described in coronavirus infection in adults, while other characteristic for them lesions were not determined. The unfavorable course of COVID-19 was facilitated by an activated intrauterine infection, mycoplasmosis or chlamydiosis according to morphological data.
About the Authors
N. N. MorozovaRussian Federation
Petrozavodsk
V. A. Zinserling
Russian Federation
Saint-Petersburg
N. Yu. Semenova
Russian Federation
Saint-Petersburg
References
1. She J., Liu L., LiuW., She J et al. COVID-19 epidemic: Disease characteristics in children J Med. Virol. 2020 92(7): 747- 754 DOI 10.1002/jmv.25807
2. Dondurey E.A., Isankina L.N., Afanasjeva O.I. et al Characteristics ofCOVID-19 in children: the first experience in the hospital of St.Petersburg. Journal infectology 2020, 12(3):53-63 (in Russian) DOI: 10.221625/2072-6732-2020-12-3-56-63
3. Ludvigson J.F. Systemic review of COVID-19 in children shows milder cases and better prognosis than adults Acta Paediatr. 2020 109 (6): 1088-1095. Doi: 10.1111/apa.15270
4. Moreira A., Chorath K., Rajsekaran K. et al. Demographic predictors of hospitalization and mortality in US children with COVID-19 Eur J. Pediatrr. 2021 : 1-5 doi: 10.1007/s00431-021-03955-x Epub ahead of print
5. Uskov A.N., Lobzin Y.V. Rychkova S.V.et al Course of a new coronavirus infection in children: some aspects of monitoring and analys of mortality. Journal infectology 2020, 12(3):12- 20 (in Russian) DOI: 10.221625/2072-6732-2020-12-3-12-20
6. Zinserling V.A. Vashukova M.A. Vassilyeva M.V. et al. Issues of pathology of a new coronavirus infection (COVID-19) Journal infectology 2020, 12(2):5-11 (in Russian) DOI 10.22625/2072-6732-2020-12-2-5-11
7. Zinserling V.A., Melnikova V.F. Perinatal Infections: questions of pathogenesis, morphological diagnostic and clinic-pathological correlations. Manual for doctors. 2002. “ElbiSPb”, 351 p ( in Russian)
Review
For citations:
Morozova N.N., Zinserling V.A., Semenova N.Yu. Case of lethal outcome of an infant due to COVID-19. Journal Infectology. 2021;13(2):142-148. (In Russ.) https://doi.org/10.22625/2072-6732-2021-13-2-142-148