Coronavirus infection in patients with HIV infection, features of the course
https://doi.org/10.22625/2072-6732-2021-13-2-61-69
Abstract
Purpose. Analyze and identify the features of the course of the new coronavirus infection (COVID-19) in HIV-infected patients.
Materials and methods. An analysis of the course of coronavirus infection (COVID-19) was carried out in 16 patients with HIV infection who were hospitalized at the St. Petersburg State Budgetary Healthcare Institution Center for the Prevention and Control of AIDS and Infectious Diseases from April to October 2020. All patients underwent a study of biological material from the oropharynx and nasopharynx for COVID-19 and diagnosed based on a positive PCR result.
Results. In HIV-infected patients with diagnosed coronavirus infection caused by COVID-19, signs of progression of HIV infection, clinical, immunological, virological (75%), opportunistic diseases and comorbidities (chronic viral hepatitis in the cirrhotic decompensated stage, cardiovascular diseases and others) (94%). A small sample of patients did not allow to determine with reliable accuracy the mutual influence of existing diseases and pathologies, but, of course, multiple comorbid pathologies play a role in the development of severe conditions and unfavorable outcomes. A clinical case is presented.
Conclusion. The provoking factors have been identified that play a role in the development of infection and more severe forms of coronavirus infection caused by COVID-19 in HIV-infected patients (injecting drug use, alcohol abuse, late stage of HIV infection (4B, 4C) and progression of earlier stages (4A ), a low number of CD4 lymphocytes (less than 200 cells / μl), multiple comorbid pathology (HIV infection, opportunistic diseases, comorbidities, especially chronic liver damage in the stage of decompensated cirrhosis), absence, interrupted antiretroviral therapy, multiple changes of regimens, absence prevention of opportunistic diseases). A patient with HIV infection at ART. 4B with multiple comorbidity, the possibility of long-term persistence of the COVID-19 virus coronavirus with positive and negative results for more than 2 months and later development of lung damage caused by COVID-19 was established.
About the Authors
E. V. Stepanova
Center for the Prevention and Control of AIDS and infectious diseases
Russian Federation
Russian Federation
Saint-Petersburg
O. N. Leonova
Center for the Prevention and Control of AIDS and infectious diseases
Russian Federation
Russian Federation
Saint-Petersburg
A. S. Shelomov
Center for the Prevention and Control of AIDS and infectious diseases
Russian Federation
Russian Federation
Saint-Petersburg
T. N. Vinogradova
Center for the Prevention and Control of AIDS and infectious diseases
Russian Federation
Russian Federation
Saint-Petersburg
References
1. Pshenichnaya N.Yu. COVID-19 – Novaya globalnaya ugroza chelovechestvu / Pshenichnaya N.Yu. [et al] // Epidemiology and infectious diseases. Topical issue – 2020. – №1. – S. 6–13
2. Ceylan Z. Estimation of COVID-19 prevalence in Italy, Spain, and France. Sci Total Environ. 2020; 729: 138817. doi:10.1016/j.scitotenv.2020.138817
3. Sebastiani G, Massa M, Riboli E. Covid-19 epidemic in Italy: evolution, projections and impact of government measures // Eur J Epidemiol. – 2020; 35(4):341-345. doi:10.1007/s10654-020-00631-6
4. World Health Organization. Infection prevention and control guidance for long-term care facilities in the context of COVID-19: interim guidance, 21 March 2020. World Health Organization; 2020.
5. “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)” Temporary guidelines of the Ministry of Health of the Russian Federation, version 9 (26.10.2020), 235 p.
6. Electronic resource: https://www.eacsociety.org/home/covid-19-and-hiv.html,
7. Electronic resource: https://www.who.int/news-room/qa-detail/q-a-on-covid-19-hiv-and-antiretrovirals,
8. Electronic resource: https://www.unaids.org/ru/resources/infographics/hiv-and-covid-19
9. Karmen-Tuohy S, Carlucci PM, Zervou FN, Zacharioudakis IM, Rebick G, Klein E, et al. Outcomes Among HIV-Positive Patients Hospitalized With COVID-19. J. Acquir. Immune Defic. Syndr. Volume 85, Number 1, September 1, 2020:6–10. DOI: 10.1097/QAI.0000000000002423.
10. Patel RH, Pella PM. COVID-19 in a patient with HIV infection J. Med. Virol. 2020;1–2. DOI: 10.1002/jmv.26049
11. Gusev D.A. Opyit ptimenenya recombinantnogo humanizirovannogo monoclonalnogo antitela k chelovecheskomu receptoru interlukina-6 u pacientov s COVID-19 / Vashukova M.A., Feduniak I.P., Musatov V.B., Kapatzina V.A. // Jurnal Infektologii. – 2020 – Т. 12, №3. – S. 28-33.
12. Malinnikova E.Yu. Novaya coronavirusnaya infectzia. // Infectious diseases^ news, opinions, training. – 2020. – Т. 9, № 2. – S. 18–32. DOI: 10.33029/2305-3496-2020-9-2-18-32
13. Ruzhentzova T.А., Chuhlaev P.V., Havkina D.А., et al. Vozmozhnosti etiotropnoy terapii coronavirusnoy infektzii, vyizvannoy SARS-CoV-2, u ambulatornyih patzientov. – Medical Opponent – 2020/ – №1(9). – S. 48-58.
14. COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/ 15. Electronic resource: Therapeutics and COVID-19: living guideline. https://www.who.int/teams/risk-communication
15. The beginning of the COVID-19 epidemic / Ed. S.F.Bagnenko, N.A. Belyakova. Saint Petersburg: Baltic Medical Education Center, 2020.360 p.
16. NHS. Coronavirus (2019-nCoV) URL: https://www.nhs.uk/conditions/wuhan-novel-coronavirus/Canada.ca. 2019 novel coronavirus: Symptoms and treatment The official website of the Government of Canada URL: https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirusinfection/symptoms.html
17. Canada.ca. 2019 novel coronavirus: Symptoms and treatment The official website of the Government of Canada URL: https://www.canada.ca/en/public health/services/diseases/2019-novel-coronavirusinfection/symptoms.html
18. Federal Ministry of Health. Current information on the coronavirus URL: https://www.bundesgesundheitsministerium.de/en/en/press/2020/coronavirus.html
19. Guaraldi G et al. 17th Conference on Retroviruses and Opportunistic Infections, 2010. San Francisco, Feb 16-19. Poster presentation # 727 http://www.retroconference.org/2010/PDFs/727.pdf
20. Benkovic S., Kim M., Sin E. Four cases: Human immunodeficiency virus and novel coronavirus 2019 Co-infection in patients from Long Island. J. Med. Virol. 2020; 92:2338–2340. DOI: 10.1002/jmv.26029
Review
For citations:
Stepanova E.V., Leonova O.N., Shelomov A.S., Vinogradova T.N. Coronavirus infection in patients with HIV infection, features of the course. Journal Infectology. 2021;13(2):61-69. (In Russ.) https://doi.org/10.22625/2072-6732-2021-13-2-61-69
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