The case of inherited chromosomal integrated human herpes virus type 6b in child with recurrent respiratory tract infections
https://doi.org/10.22625/2072-6732-2020-12-4-105-108
Abstract
The five years old boy with recurrent respiratory tract infections was under observation of infectiologist due to high levels of human herpes virus type 6 (HHV-6), found in patient’s blood and saliva during a few years. The patient got the medicines against the HHV-6, without any effect. We investigated the patient’s and his mom’s nails and found the HHV-6 type B, so it was inherited chromosomal integrated HHV-6. Thus, to avoid the unnecessary treatment, in case of repeated high level of HHV-6, we need to exclude chromosomal integrated HHV-6.
About the Authors
M. A. Nikolsky
First Saint-Petersburg State Medical University named after academician I.P. Pavlov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. A. Vyazovaya
Research Institute of Epidemiology and Microbiology named after Pasteur
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
D. A. Lioznov
First Saint-Petersburg State Medical University named after academician I.P. Pavlov;
Research Institute of Influenza named after A.A. Smorodintsev
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
O. V. Narvskaya
Research Institute of Epidemiology and Microbiology named after Pasteur
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
N. N. Smirnova
First Saint-Petersburg State Medical University named after academician I.P. Pavlov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
References
1. Lysenkova M.Yu., Karazhas N.V., Melekhina E.V., Rybalkina T.N., Veselovsky P.A., Burmistrov E.M., Boshyan R.E., Muzyka A.D., Gorelov A.V. Herpesvirus infections in children with recurrent respiratory diseases. Children infections. 2018;17(2):17-21.
2. Flamand L., Lautenschlager I., Krueger G. Ablashi D. Human Herpesviruses HHV-6A, HHV-6B, and HHV-7. Diagnosis and Clinical Management. Third edition 2014. 341 p.
3. Leen De Bolle, Lieve Naesens, Erik De Clercq. Update on human herpesvirus 6 biology, clinical features and therapy. Clinical Microbiology reviews, Jan.2005. P.217-245.
4. Clark DA. Clinical and laboratory features of human herpesvirus 6 chromosomal integration//Clin Microbiol Infect. 2016 Apr; 22(4):333-9.
5. Domonova E.A., Silveistrova О.Yu., Goptar I.А., Кuleshov K.,.VNikiforova A.V., Matosova S.V., Shipulina О.Yu. First data on the prevalence of inherited chromosomally integrated Human betaherpesvirus 6A/B in Russia. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2019; 9(4): 43–50
6. Domonova Е.А., Silveystrova О.Yu., Goptar I.A., Kuleshov K.V., Paskhina I.N., Nikiforova A.V., Shipulina О.Yu., Markelov М.L., Shipulin G.A., Maleev V.V. First laboratory сonfirmed case of hereditary transmission of chromosomally integrated Human betaherpesvirus 6A in the Russian Federation. Infekc. bolezni (Infectious diseases). 2019; 17(3): 5–14.
7. Pellett P.E., Ablashi D.V., Ambros P.F. et al. Chromosomally integrated human herpesvi- rus 6: questions and answers. Rev. Med. Virol., 2012, vol. 22, no. 3, pp. 144–155.
8. Caserta M.T., Hall C.B., Canfield R.L., Davidson P., Lofthus G., Schnabel K., Carnahan J., Shelley L., Wang H. Early developmental outcomes of children with congenital HHV-6 infection. // Pediatrics. 2014 Dec;134(6):1111-8.
9. Gravel A, Dubuc I, Morissette G. Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8058-63.
10. Bhupesh K.P., Krohne G., Rudel T. Reactivation of Chromosomally Integrated Human Herpesvirus-6 by Telomeric Circle Formation. PLoS Genet. 2013, Vol. 9, no.12, Published online.
11. Montoya J.G., Neely M.N., Gupta S. Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction. J Clin Virol. 2012, Vol.55, no.1, pp. 40-5.
12. Agut H, Bonnafous P, Gautheret-Dejean A. Laboratory and clinical aspects of human herpesvirus 6 infections. Clin.Microbiol. Rev. 2015; 28 (2): 313–335.
Review
For citations:
Nikolsky M.A., Vyazovaya A.A., Lioznov D.A., Narvskaya O.V., Smirnova N.N. The case of inherited chromosomal integrated human herpes virus type 6b in child with recurrent respiratory tract infections. Journal Infectology. 2020;12(4):105-108. (In Russ.) https://doi.org/10.22625/2072-6732-2020-12-4-105-108
Views:
941
.png)
.png)
Email this article 