Safety of pertussis vaccines for adolescents
https://doi.org/10.22625/2072-6732-2020-12-4-29-36
Abstract
Aim: to investigate the safety of acellular pertussis vaccines for adolescents.
Materials and methods. The clinical tolerability of revaccination against pertussis (cell-free component), diphtheria and tetanus was analyzed in 107 children aged 13,5–14 years. Group 1 consisted of children revaccinated with DTacP-IPV combined vaccine (Tetraxim), group 2 – vaccinated with Td and group 3 – children who received Tdap vaccine (Adacel).
Results. Statistically significant differences in the frequency of local reactions between the group that received Tdap and the other two (DTacP-IPV and Td) were detected (p = 0.001and p = 0.04, respectively). Analysis of the structure of local reactions revealed a difference only in the occurrence of the hyperemia at the site of injection, with the most frequent registration in the groups of children vaccinated with DTacPIPV (29,4%) and Td (14,7%), whereas in patients vaccinated with Tdap – only in 5,9% (χ2 = 6,8 p = 0,03). Systemic reactions occurred with the same frequency in all studied groups and did not require medical correction, as well as local reactions. Thus, revaccination against pertussis, diphtheria and tetanus of adolescents using Tdap, containing the acellular pertussis component, does not exceed the frequency of systemic reactions and the number of local reactions is significantly lower in comparison with the vaccine with a reduced content of diphtheria and tetanus toxoids (Td) that is used in practice for a long time.
About the Authors
M. P. Kostinov
Research Institute of Vaccines and Sera named after I.I. Mechnikov;
The First Moscow State Medical University named after I.M. Sechenov (Sechenov University)
Russian Federation
Moscow
Russian Federation
Moscow
E. V. Prutskova
Ulyanovsk State University
Russian Federation
Ulyanovsk
Russian Federation
Ulyanovsk
A. P. Cherdantsev
Ulyanovsk State University
Russian Federation
Ulyanovsk
Russian Federation
Ulyanovsk
G. R. Feiskhanova
Ulyanovsk Guards Suvorov Military School
Russian Federation
Ulyanovsk
Russian Federation
Ulyanovsk
A. M. Kostinov
Moscow State University named after M.V. Lomonosov
Russian Federation
Moscow
Russian Federation
Moscow
A. E. Vlasenko
Novokuznetsk State Institute for Further Training of Physicians – Branch Campus of the Russian Medical Academy of Continuous Professional Education
Russian Federation
Moscow
Russian Federation
Moscow
V. B. Polishchuk
Research Institute of Vaccines and Sera named after I.I. Mechnikov
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Kostinov M.P., Prutskova E.V., Cherdantsev A.P., Feiskhanova G.R., Kostinov A.M., Vlasenko A.E., Polishchuk V.B. Safety of pertussis vaccines for adolescents. Journal Infectology. 2020;12(4):29-36. (In Russ.) https://doi.org/10.22625/2072-6732-2020-12-4-29-36
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