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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2019-11-4-148-152</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-974</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case</subject></subj-group></article-categories><title-group><article-title>Цитомегаловирусная инфекция после ортотопической трансплантации печени (клинический случай)</article-title><trans-title-group xml:lang="en"><trans-title>Cytomegalovirus infection in patients after orthotopic liver transplantation (clinical report)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремов</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremov</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефремов Дмитрий Олегович - клинический ординатор клиники инфекционных болезней с курсом медицинской паразитологии и тропических заболеваний.</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">Efremov-d24@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герасимова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gerasimova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Герасимова Ольга Анатольевна - ведущий научный сотрудник, доктор медицинских наук.</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">ren321@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлов Константин Вадимович - доцент кафедры инфекционных болезней с курсом медицинской паразитологии и тропических заболеваний, доктор медицинских наук.</p><p>Санкт-Петербург, тел.: 8(812)271-87-26</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">kosttiak@mfil.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Габдрахманов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gabdrakhmanov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Габдрахманов Ильнур Адисович — старший ординатор клиники инфекционных болезней с курсом медицинской паразитологии и тропических заболеваний, кандидат медицинских наук.</p><p>Санкт-Петербург, тел.: +7-921-885-37-57</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">ilnur87rahmanov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жданов</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhdanov</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жданов Константин Валерьевич — начальник кафедры инфекционных болезней с курсом медицинской паразитологии и тропических заболеваний, доктор медицинских наук, профессор, член-корреспондент РАН.</p><p>Санкт-Петербург, тел.: 8(812)271-87-26</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">zhdanovkv@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Военно-медицинская академия имени С.М. Кирова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Military Medical Academy named after S.M. Kirov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский научный центр радиологии и хирургических технологий имени академика А.М. Гранова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center for Radiology and Surgical Technologies named after academician A.M. Granov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>08</day><month>12</month><year>2019</year></pub-date><volume>11</volume><issue>4</issue><fpage>148</fpage><lpage>152</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ефремов Д.О., Герасимова О.А., Козлов К.В., Габдрахманов И.А., Жданов К.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Ефремов Д.О., Герасимова О.А., Козлов К.В., Габдрахманов И.А., Жданов К.В.</copyright-holder><copyright-holder xml:lang="en">Efremov D.O., Gerasimova O.A., Kozlov K.V., Gabdrakhmanov I.A., Zhdanov K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/974">https://journal.niidi.ru/jofin/article/view/974</self-uri><abstract><p>Герпес-вирусы, широко распространены, в человеческой популяции, они способны поражать практически все органы, и системы организма. В настоящее время известно 8 серотипов герпес-вирусов, патогенных для человека: вирусы, простого герпеса 1-го и 2-го типа, ветряной оспы. — опоясывающего герпеса, цитомегалови-рус, вирус Эпштейна — Барр, вирусы, герпеса человека 6-го, 7-го и 8-го типов. Первичное инфицирование герпес-вирусами в 60—90% случаев происходит, в раннем. детском возрасте, и, как правило, не сопровождается типичными клиническими проявлениями. В связи с отсутствием в нашей стране обязательной регистрации заболеваемости герпес-вирусными инфекциями истинное число больных неизвестно. Считают, что на территории России и стран СНГ ежегодно инфицируется около 20 млн. человек. Герпес-вирусы, в большей или меньшей степени могут считаться гепатотропными. Большое число исследований посвящено проблеме цитомега-ловирусной инфекции, одним, из проявлений которой является гепатит.. Наиболее часто цитомегаловирусный гепатит, встречается у иммунокомпрометированных лиц или у пациентов, получающих иммуносупрессивную терапию, также описываются случаи цитомегалови-русного гепатита и у иммунокомпетентных лиц. При трансплантации печени без противовирусной терапии цитомегаловирусная инфекция проявляется у 11—28,5% реципиентов и может приводить к развитию печеночной недостаточности, потере трансплантата и гибели реципиента. Выполнение диагностических исследований как серологическими, так и молекулярно-биологическими методами на разных сроках после трансплантации печени позволяет, своевременно выявить цитомегаловирусную инфекцию, начать лечение и тем самым, избежать отторжения трансплантата и гибели реципиента.</p></abstract><trans-abstract xml:lang="en"><p>Herpes viruses are widespread in the human population, they are able to infect almost all organs and systems of the body. Currently, 8 serotypes of herpesviruses pathogenic for humans are known: herpes simplex viruses of the 1st and 2nd. type, chickenpox — herpes zoster, cytomegalovirus, Epstein-Barr virus, 6th, 7th and 8th human herpes viruses. Primary infection with herpes viruses in 60—90% of cases occurs in early childhood, and, as a rule, is not accompanied, by typical clinical manifestations. Due to the lack of mandatory registration of the incidence of herpes virus infections in our country, the true number of patients is unknown. It is believed that about 20 million people are infected, every year in Russia and. the CIS countries. Herpes viruses, to a greater or lesser extent, can be considered, hepatotropic. A large number of studies are devoted, to the problem, of cytomegalovirus infection, one of the manifestations of which, is hepatitis. Most often, cytomegalovirus hepatitis occurs in immunocompromised. individuals or in patients receiving immunosuppressive therapy, cases of cytomegalovirus hepatitis and in immunocompetent individuals are also described. With liver transplantation without antiviral therapy, cytomegalovirus infection manifests itself in 11-28,5% of recipients and. can lead, to the development of liver failure, loss of transplant and. death, of the recipient. Performing diagnostic studies using both, serological and. molecular biological methods at different periods after liver transplantation, allows to detect cytomegalovirus infection timely and. initiate treatment, thereby avoiding graft rejection and. the death, of the recipient.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>герпес-вирусы</kwd><kwd>цитомегаловирусная инфекция</kwd><kwd>цитомегаловирусный гепатит</kwd><kwd>иммуносупрессивная терапия</kwd><kwd>ортотопическая трансплантация печени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Herpes viruses</kwd><kwd>cytomegalovirus infection</kwd><kwd>cytomegalovirus hepatitis</kwd><kwd>immunosuppressive therapy</kwd><kwd>orthotopic liver transplantation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Исаков, В.А. Герпес-вирусные инфекции человека : руководство для врачей / В.А. Исаков, Е.И. Архипова, Д.В. 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