jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2019-11-2-14-19jofin-878Research ArticleОбзорReviewПлазмоцитоидные дендритные клетки и их роль в иммунопатогенезе вирусных инфекций на примере гепатита ВPlasmacytoid dendritic cells and their role in the immunopathogenesis of viral infections for example hepatitis BХоджибековР. Р.KhodzhibekovR. R.

Ходжибеков Расим Ринатович – ассистент кафедры инфекционных болезней с курсами эпидемиологии и фтизиатрии 

Москва

rasim.khodzhibekov@yandex.ruХохловаО. Н.KhokhlovaO. N.

Хохлова Ольга Николаевна – младший научный сотрудник специализированного научно-исследовательского отдела эпидемиологии и профилактики СПИДа 

Москва

x.olia79@mail.ruРейзисА. Р.ReizisA. R.

Рейзис Ара Романовна – ведущий научный сотрудник доктор медицинских наук, профессор

Москва

bobandara@mail.ruКожевниковаГ. М.KozhevnikovaG. M.

Кожевникова Галина Михайловна – заведующая кафедрой инфекционных болезней с курсами эпидемиологии и фтизиатрии, доктор медицинских наук, профессор

Москва

gmk-10@mail.ruРоссийский университет дружбы народовРоссияPeoples Friendship University of RussiaRussian FederationЦентральный научно-исследовательский институт эпидемиологииРоссияCentral Research Institute of EpidemiologyRussian Federation2019160520191121419Copyright © Ходжибеков Р.Р., Хохлова О.Н., Рейзис А.Р., Кожевникова Г.М., 20192019Ходжибеков Р.Р., Хохлова О.Н., Рейзис А.Р., Кожевникова Г.М.Khodzhibekov R.R., Khokhlova O.N., Reizis A.R., Kozhevnikova G.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/878

Новым направлением в понимании механизмов иммунного ответа при вирусных гепатитах является открытие уникального типа иммунных клеток – плазмоцитоидных дендритных клеток (pDCs). Плазмоцитоидные дендритные клетки (pDCs) – клетки лимфоидного происхождения и морфологически напоминают плазматические клетки. Функционально являются профессиональными ИФН-a-продуцирующими клетками, которые играют важную роль в противовирусном иммунном ответе. Данные о механизмах участия pDCs при инфекции вирусом гепатита В немногочисленны и противоречивы. При хронической инфекции ВГВ роль pDCs остается загадочной и плохо изученной с противоречивыми результатами pDCs циркулирующей крови, которые по-разному показывают, что они не затронуты или уменьшены. Тем не менее, отмечались функциональные нарушения pDCs у пациентов с хронической инфекцией ВГВ. Установление этих механизмов, а также поиск причины ускользания вируса гепатита В от иммунной системы и формирования хронической инфекции остаётся на сегодняшний день одним из важных и перспективных направлений научной деятельности.

A new approach in understanding the mechanisms of immune response in viral hepatitis is the discovery of a unique type of immune cells – plasmocytoid dendritic cells (pDCs). Plasmocytoid dendritic cells (pDCs) are cells of lymphoid origin and morphologically resemble plasma cells. Functionally, they are professional IFN-a-producing cells that play an important role in antiviral immune response. Data on the mechanisms of PDCs participation in hepatitis B virus infection are few and contradictory. In chronic HBV infection, the role of pDCs remains mysterious and poorly understood with conflicting circulating blood pDCs results that show differently that they are not affected or reduced. However, functional disorders of pDCs were observed in patients with chronic HBV infection. The establishment of these mechanisms, as well as the search for the cause of hepatitis B virus latency and the formation of chronic infection remains one of the important and promising areas of scientific activities today.

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The authors declare that there are no conflicts of interest present.