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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2018-10-4-89-95</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-809</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальное исследование</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ ВИЧ-ИНФИЦИРОВАННОСТИ НА СТРУКТУРУ ВНЕЛЕГОЧНОГО ТУБЕРКУЛЕЗА В СИБИРИ И НА ДАЛЬНЕМ ВОСТОКЕ</article-title><trans-title-group xml:lang="en"><trans-title>The impact of HIV infection on spectrum of extrapulmonary tuberculosis in Siberia and Far East</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кульчавеня</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulchavenya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор, главный научный сотрудник; профессор кафедры туберкулеза, д.м.н., профессор; </p><p>тел.: 8(383)203-79-89</p></bio><email xlink:type="simple">urotub@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новосибирский научно-исследовательский институт туберкулеза, Новосибирск; Новосибирский государственный медицинский университет, Новосибирск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk Research Institute of Tuberculosis, Novosibirsk; Novosibirsk State Medical University, Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>29</day><month>12</month><year>2018</year></pub-date><volume>10</volume><issue>4</issue><fpage>89</fpage><lpage>95</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кульчавеня Е.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Кульчавеня Е.В.</copyright-holder><copyright-holder xml:lang="en">Kulchavenya E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/809">https://journal.niidi.ru/jofin/article/view/809</self-uri><abstract><p>Введение. Инфицирование вирусом иммунодефицита человека (ВИЧ) является фактором риска для туберкулеза, повышая вероятность его развития в 20–37 раз. Цель исследования: определение влияния инфицирования вирусом иммунодефицита человека на структуру клинических форм внелегочного туберкулеза. Материал и методы: проанализированы данные отчетов противотуберкулезных диспансеров Сибирского и Дальневосточного федеральных округов за 2016 и 2017 гг. В разработку включены 1227 пациентов с изолированными формами внелегочного туберкулеза, у которых определен статус инфицирования вирусом иммунодефицита человека. Результаты. В общей структуре клинических форм внелегочного туберкулеза в Сибири и на Дальнем Востоке, оцениваемой независимо от ВИЧ-инфицирования, ведущей формой с большим преобладанием был костносуставной туберкулез (41,0%). Второе и третье места делят урогенитальный туберкулез и туберкулез центральной нервной системы (19,4% и 18,7% соответственно). Структура клинических форм внелегочного туберкулеза в зависимости от ВИЧ-инфицирования кардинально меняется. У ВИЧ-инфицированных на первом месте стоял туберкулез центральной нервной системы (43,8%), на втором – костно-суставной туберкулез (34,5%), на третьем – туберкулез периферических лимфатических узлов (11,7%). Доля урогенитального туберкулеза у ВИЧ-инфицированных ничтожно мала (1,9%). В анализируемом двухлетнем периоде значимой динамики в пропорциях внелегочных локализаций туберкулеза как у ВИЧ-инфицированных, так и у иммунокомпетентных больных не отмечено. Заключение. ВИЧ-инфекция кардинально меняет структуру клинических форм внелегочного туберкулеза. Полагаем необходимым внести изменения в систему учета больных внелегочным туберкулезом, выделив ВИЧ-инфицированных в отдельную группу.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Human immunodeficiency virus (HIV) infection is a risk factor for tuberculosis (TB), increasing the likelihood of its development in 20–37 times. The purpose of the study was to evaluate an influence of HIV infection on a spectrum of extrapulmonary tuberculosis (EPTB). Material and methods. Statistical reports of dispensaries on tuberculosis in Siberia and Far East were analyzed for 2016–2017 years. Of total 1227 patients with isolated EPTB (without pulmonary TB) who have the status of HIV infection were enrolled in the study. пациентов с изолированными формами ВЛТ, у которых определен статус ВИЧинфицирования. Results. In the overall spectrum of the incidence of EPTB in Siberia and the Far East, estimated independently from HIV infection, the leading form with a large predominance was the bone and joints TB (41,0%). The second-third place was divided by urogenital tuberculosis and tuberculosis of the central nervous system (19,4% and 18,7% respectively). The spectrum of the incidence of EPTB changed dramatically depending on HIV infection. If in HIV-infected patients most common form was TB of the central nervous system (43.8%), followed by the second – the bone and joints TB (34.5%), and TB of peripheral lymph node TB (11.7%). The proportion of urogenital tuberculosis in HIV-infected was negligible (1.9%). In the analyzed period, significant changes in the proportions of extrapulmonary tuberculosis localization in both HIV-infected and immunocompetent patients were not found. Conclusion. HIV infection dramatically changes the spectrum of the incidence of EPTB. We recommend making changes in the system of recording patients with EPTB, allocating HIV-infected to a separate group.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внелегочный туберкулез</kwd><kwd>ВИЧинфекция</kwd><kwd>коморбидность ВИЧ/туберкулез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>extrapulmonary tuberculosis</kwd><kwd>HIV infection</kwd><kwd>comorbidity of HIV/tuberculosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shivakoti R, Sharma D, Mamoon G, Pham K. Association of HIV infection with extrapulmonary tuberculosis: a systematic review. Infection. 2017 Feb;45(1):11-21. doi: 10.1007/s15010-016-0960-5.</mixed-citation><mixed-citation xml:lang="en">Shivakoti R, Sharma D, Mamoon G, Pham K. Association of HIV infection with extrapulmonary tuberculosis: a systematic review. 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