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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2018-10-3-84-90</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-762</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>КОМПРЕССИОННАЯ ЭЛАСТОГРАФИЯ И ЕЕ ИСПОЛЬЗОВАНИЕ В КЛИНИЧЕСКОЙ ПРАКТИКЕ В СРАВНЕНИИ С ДРУГИМИ МЕТОДАМИ ОЦЕНКИ СТЕПЕНИ ФИБРОЗА В ТКАНИ ПЕЧЕНИ У БОЛЬНЫХ С ХРОНИЧЕСКИМ ГЕПАТИТОМ С</article-title><trans-title-group xml:lang="en"><trans-title>REAL-TIME ELASTOGRAPHY AND ITS CLINICAL APPLICATION COMPARED WITH OTHER METHODS FOR EVALUATION OF THE LIVER FIBROSIS DEGREE IN PATIENTS WITH CHRONIC HEPATITIS C</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белопольская</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belopolskaya</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-инфекционист;</p><p>научный сотрудник,</p><p>к.м.н.,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">belopolskaya.maria@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аврутин</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Avrutin</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник, д.т.н.,</p><p>Штутгарт</p></bio><bio xml:lang="en"><p>Stuttgart</p></bio><email xlink:type="simple">viktor.avrutin@ist.uni-stuttgart.de</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>О. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>O. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач ультразвуковой диагностики,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">denisova-kuzmina@rambler.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Личная</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lichnaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник лаборатории молекулярной эпидемиологии и эволюционной генетики,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">evlichnaya@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юшина</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Yushina</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-инфекционист,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">yushinaeu1976@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гурина</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurina</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач ультразвуковой диагностики,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">s.gurina@inbox.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>директор Института экспериментальной медицины;</p><p>профессор кафедры фундаментальных проблем медицины и медицинских технологий факультета стоматологии и медицинских технологий,</p><p>д.б.н., профессор РАН,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">admitriev10@yandex.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovlev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>главный врач;</p><p>профессор,</p><p>д.м.н., профессор, заслуженный врач РФ,</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">aay28@yandex.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Клиническая инфекционная больница имени С.П. Боткина;&#13;
Институт экспериментальной медицины<country>Россия</country></aff><aff xml:lang="en">Clinical Infectious Diseases Hospital named after S.P. Botkin;&#13;
Institute of Experimental Medicine<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Институт теории систем автоматического управления<country>Германия</country></aff><aff xml:lang="en">Institute for Systems Theory<country>Germany</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Клиническая инфекционная больница имени С.П. Боткина<country>Россия</country></aff><aff xml:lang="en">Clinical Infectious Diseases Hospital named after S.P. Botkin<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера<country>Россия</country></aff><aff xml:lang="en">Saint-Petersburg Science Research Institute of Epidemiology and Microbiology named after Pasteur<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">Институт экспериментальной медицины;&#13;
Санкт-Петербургский государственный университет<country>Россия</country></aff><aff xml:lang="en">Institute of Experimental Medicine;&#13;
Saint-Petersburg State University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru">Клиническая инфекционная больница имени С.П. Боткина;&#13;
Санкт-Петербургский государственный университет<country>Россия</country></aff><aff xml:lang="en">Clinical Infectious Diseases Hospital named after S.P. Botkin;&#13;
Saint-Petersburg State University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2018</year></pub-date><volume>10</volume><issue>3</issue><fpage>84</fpage><lpage>90</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белопольская М.А., Аврутин В.Ю., Денисова О.Д., Личная Е.В., Юшина Е.Ю., Гурина С.И., Дмитриев А.В., Яковлев А.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Белопольская М.А., Аврутин В.Ю., Денисова О.Д., Личная Е.В., Юшина Е.Ю., Гурина С.И., Дмитриев А.В., Яковлев А.А.</copyright-holder><copyright-holder xml:lang="en">Belopolskaya M.A., Avrutin V.Y., Denisova O.D., Lichnaya E.V., Yushina E.Y., Gurina S.I., Dmitriev A.V., Yakovlev A.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/762">https://journal.niidi.ru/jofin/article/view/762</self-uri><abstract><sec><title>Цель</title><p>Цель: оценить сопоставимость результатов оценки степени фиброза печени, полученных методами ТЭ и КЭ, между собой и с показателями APRI-индекса, а также проанализировать факторы, влияющие на достоверность оценки степени фиброза при использовании различных неинвазивных методов.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: в исследование были включены 99 пациентов с ХГС, наблюдавшихся в поликлиническом отделении Клинической инфекционной больницы имени С.П. Боткина в 2017 г. Среди обследованных пациентов было 60 женщин и 39 мужчин. Оценка степени фиброза в ткани печени методом КЭ с использованием линейного датчика на аппарате HI VISION Preirus (Hitachi, Япония) была выполнена у 83 пациентов. Оценка степени фиброза в ткани печени методом ТЭ на аппарате Fibroscan (Echosens, Франция) была выполнена у 67 пациентов. Обоими методами оценки фиброза был обследован 51 пациент.</p></sec><sec><title>Выводы</title><p>Выводы. Результаты применения методов КЭ и ТЭ не имеют существенных отличий у пациентов со степенью фиброза F4 по шкале METAVIR. У одних и тех же пациентов с ХГС метод КЭ часто дает более высокие степени фиброза, чем метод ТЭ. В связи с возможностью большей визуализации исследуемой области метод КЭ имеет явные преимущества при оценке степени фиброза в ткани печени у больных с имеющимися очаговыми изменениями. При несовпадении результатов должны использоваться альтернативные методы оценки степени фиброза в ткани печени, такие как биопсия печени и/или биохимические методы оценки фиброза. </p></sec></abstract><trans-abstract xml:lang="en"><p>In this work we investigated to which extent the evaluation results of the degree of hepatic fibrosis obtained by realtime elastography (RTE) method are compatible with the results of the transient elastography (TE) and with the APRI indexes. We also analyzed the factors which can influence the reliability of the fibrosis degree evaluation obtained by different methods.</p><sec><title>Materials and methods</title><p>Materials and methods. The study included 99 patients (60 women and 39 men) with HCV, examined in the polyclinic department of the Saint-Petersburg Botkin clinical infectious hospital in 2017. In 83 patients, the fibrosis degree in the liver tissue has been evaluated by the RTE method using HI VISION Preirus (Hitachi, Japan) with a linear sensor. In 67 patients, the evaluation has been performed by the TE method using Fibroscan (Echosens, France). Both methods have been applied to 51 patients.</p></sec><sec><title>Conclusions</title><p>Conclusions. The aplication results of the RTE and TE methods do not differ significantly for patients with a severe fibrosis. Usually, the degree of fibrosis in patients with CHC obtained by the RTE is higher than the one obtained by the TE in the same patient. Due to the possibility to visualize a larger area under study, the RTE method has clear advantages in evaluating the degree of fibrosis in liver tissue in patients with focal changes in the liver. If the results obtained by the RTE and TE methods differ significantly, alternative methods must be used, such as a liver biopsy and biochemical methods.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>компрессионная эластография</kwd><kwd>транзиентная эластография</kwd><kwd>хронический гепатит С</kwd><kwd>APRI-индекс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>сompression Elastography</kwd><kwd>Transient elastography</kwd><kwd>chronic hepatitis C</kwd><kwd>APRI-index</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yano, M., Kumada, H., Kage M., Ikeda, K., Shimamatsu, K., Inoue, O., Hashimoto, E., Lefkowitch, JH., Ludwig, J., Okuda, K. The long-term pathological evolution of chronic hepatitis C. 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