jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2018-10-3-41-44jofin-755Research ArticleОбзорReviewНАУЧНЫЕ ПЕРСПЕКТИВЫ ИЗУЧЕНИЯ ПРИЧИННО-СЛЕДСТВЕННОЙ СВЯЗИ МИКРОБИОТЫ КИШЕЧНИКА И СОСТОЯНИЯ НЕРВНОЙ СИСТЕМЫSCIENTIFIC PERSPECTIVES OF STUDY OF THE CAUSAL-INVESTIGATION CONNECTION OF MICROBIOTES OF THE INTESTINE AND THE STATE OF THE NERVOUS SYSTEMСкрипченкоН. В.SkripchenkoN. V.

заместитель директора по научной работе, руководитель центра демиелинизирующих заболеваний и рассеянного склероза у детей;

заведующая кафедрой инфекционных болезней ФП и ДПО,

д.м.н., профессор, заслуженный деятель науки РФ,

Санкт-Петербург

Saint-Petersburg

snv@niidi.ruУкраинцевС. Е.UkraintsevS. E.

медицинский директор,

Москва

Moscow

doctorsergey@mail.ruМакароваЕ. Г.MakarovaE. G.

научный советник,

Москва

Moscow

Evgenia.makarova@ru.nestle.comСкрипченкоЕ. Ю.SkripchenkoE. Yu.

старший научный сотрудник отдела нейроинфекций и органической патологии нервной системы;

доцент кафедры психоневрологии ФП и ДПО, к.м.н.,

Санкт-Петербург

Saint-Petersburg

wwave@yandex.ruДетский научно-клинический центр инфекционных болезней; Санкт-Петербургский государственный педиатрический медицинский университетРоссияPediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical UniversityRussian FederationИнститут питания НестлеРоссияNestle Nutrition InstituteRussian Federation2018041020181034144Copyright © Скрипченко Н.В., Украинцев С.Е., Макарова Е.Г., Скрипченко Е.Ю., 20182018Скрипченко Н.В., Украинцев С.Е., Макарова Е.Г., Скрипченко Е.Ю.Skripchenko N.V., Ukraintsev S.E., Makarova E.G., Skripchenko E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/755

В обзорной статье представлено научное обоснование перспективного направления исследования кишечной микробиоты и ее роли в формировании различной неврологической патологии. Отражены сведения об энтеральной нервной системе, имеющей непосредственное значение во взаимодействии между мозгом и кишечником. Исследование кишечной микробиоты в настоящее время проводится с помощью современных методов метагеномики, секвенирования и биоинформационного анализа. Представлены данные о формировании функциональных расстройств пищеварения у детей с измененной кишечной микробиотой и определены пути коррекции.

The review article presents the scientific substantiation of the prospective direction of research of the intestinal microbiota and its role in the formation of various neurological pathologies. Reflected information about the enteral nervous system, which has direct relevance in the interaction between the brain and intestines. The study of the intestinal microbiota is currently carried out using modern methods of metagenomics, sequencing and bioinformation analysis. Data are presented on the formation of functional digestive disorders in children with altered intestinal microbiota and the ways of correction are determined.

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The authors declare that there are no conflicts of interest present.