jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2018-10-2-117-122jofin-737Research ArticleНовое в диагностикеNew in DiagnosticsФЕКАЛЬНЫЙ КАЛЬПРОТЕКТИН В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ОСТРЫХ КИШЕЧНЫХ ИНФЕКЦИЙFecal calprotectin in the differential diagnosis of acute intestinal infectionsВълковаЕ. Д.VlkovaE. D.

ассистент кафедры инфекционных болезней, паразитологии и  дерматовенерологии Медицинского университета «Профессор доктор  Параскев Стоянов»; тел.: +359-52-97-87-10

Varna, Bulgaria

evalkova83@gmail.comГосподиноваМ. Д.GospodinovaM. D.

руководитель кафедры инфекционных болезней, паразитологии и  дерматовенерологии Медицинского университета «Профессор доктор  Параскев Стоянов», д.м.н., доцент; тел.: +359-52-97-87-20 

Varna, Bulgaria

dr_m_gospodinova@abv.bgТодоровИ. Т.TodorovI. T.

ассистент кафедры инфекционных болезней, паразитологии и дерматовенерологии Медицинского университета «Профессор доктор Параскев Стоянов»; тел.: +359-52-97-87-10

Varna, Bulgaria

ilio_87@abv.bgМедицинский университет «Профессор доктор Параскев Стоянов»БолгарияMedical University «Prof. Dr. Paraskev Stoyanov»Bulgaria201802072018102117122Copyright © Вълкова Е.Д., Господинова М.Д., Тодоров И.Т., 20182018Вълкова Е.Д., Господинова М.Д., Тодоров И.Т.Vlkova E.D., Gospodinova M.D., Todorov I.T.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/737Введение

Введение: острые кишечные инфекции с диарейным синдромом занимают лидирующее  место в инфекционной патологии в мировом масштабе. Разнообразие возбудителей  заставляет искать индивидуальный диагностический и терапевтический подход к  пациентам. Рутинные бактериологические и вирусологические методы занимают  продолжительное время до получения результатов, поэтому введение дополнительных лабораторных показателей, помогающих клиницистам при дифференциальной диагностике,  было бы практически важным. Один из таких маркеров – фекальный кальпротектин.

Цель

Цель: изучение роли фекального кальпротектина в диагностике острых кишечных  инфекций с диарейным синдромом.

Материалы и методы

Материалы и методы: проанализированы различные литературные источники по  указанной проблеме, доступные в национальной и международной медицинской литературе.

Результаты

Результаты: представлены данные относительно структуры, функциональной активности и  диагностической роли фекального кальпротектина при кишечных инфекциях.

Заключение

Заключение: исследование фекального кальпротектина помогает дифференциально- диагностическому процессу у пациентов с острыми кишечными инфекциями, коррелируя с  бактериальной этиологией заболевания.

Infectious diarrhea takes a leading position in all infectious diseases  worldwide. As a result of the pathogens diversity, patient-specific  diagnosis and treatments are needed. Additional laboratory tests are crucial for differentiation among pathogens, as routine  bacteriological and virological methods are time-consuming. One of them is fecal calprotectin.

Aim

Aim: examination of the potential role of fecal calprotectin in infectious diarrhea.

Materials and methods

Materials and methods: the national and international medical literature sources were analyzed.

Results

Results: the data regarding fecal calprotectins’ structure, functional activity and diagnostic value are presented.

Conclusions

Conclusions: the study of fecal calprotectin, as a correlative biomarker of bacterial gastroenteritis, can be helpful for clinicians with diagnostic approach to the patient.

фекальный кальпротектиндиареякишечные инфекциибактериимаркерfecal calprotectindiarrheabacterial gastroenteritisbiomarkerReferencesGlobal, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Vos, Theo et al. The Lancet , Volume 386 , Issue 9995 , 743 – 800Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990– 2013: a systematic analysis for the Global Burden of Disease Study 2013. Vos, Theo et al. The Lancet , Volume 386 , Issue 9995 , 743 – 800Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet , Volume 385 , Issue 9963 , 117 – 171Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990– 2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet , Volume 385 , Issue 9963 , 117 – 171WHO-MCEE methods and data sources for child causes of death 2000-2015 (Global Health Estimates Technical Paper WHO/HIS/IER/GHE/2016.1. Available from: http://www.who.int/healthinfo/global_burden_disease/en/WHO-MCEE methods and data sources for child causes of death 2000-2015 (Global Health Estimates Technical Paper WHO/HIS/IER/GHE/2016.1. Available from: http://www.who.int/healthinfo/global_burden_disease/en/Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151-61.Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151-61.Ермоленко, К.Д. Вирусные гастроэнтериты у детей: современные представления об эпидемиологии и профилактике / К.Д. Ермоленко, Ю.В. Лобзин, Н.В. Гончар // Журнал инфектологии. – 2015. – № 7(3). – С. 22–32.Ermolenko K.D., Lobzin Y.V., Gonchar N.V. Viral gastroenteritis in children: modern concepts of epidemiology and prevention. Journal Infectology. 2015;7(3):22- 32. (In Russ.)Господинова М. Д. Диференциална диагноза и лечение на диариен синдром в инфектологията / Health.bg – 2014. – № 3. – С. 44–48.Gospodinova M. D. Health.bg – 2014. – №3. – С. 44-48. (In Bulg.)Тихолова М., Ненова М., Стойчева-Въртигова М. Лечение на остри чревни инфекциозни заболявания при възрастни и деца. Консенсус на Българско дружество по инфекциозни болести. 31.10.2007г. Available from: http://bsid- bg.org/index.php/consensi/acute-int-infectionsTiholova M., Nenova M., Stojcheva-Vrtigova M. Konsensus na Blgarsko druzhestvo po infekciozni bolesti 31.10.2007г. Available from: http://bsid- bg.org/index.php/consensi/acuteint-infections (In Bulg.)Тихомирова, О.В. Вирусные диареи у детей: особенности клинического течения и тактика терапии / О.В. Тихомирова [и др.] // Детские инфекции. – 2003. – № 3. – C. 7–10.Tihomirova O.V., Sergeeva N.V., Sirotkin A.K., Aksenov O.A., Kvetnaja A.S. Detskie infekcii. 2003. №3. – C.7-10. (In Russ.)Инфекциозни болести: учебник / И.Н.Диков [и др.]. – Знание, 2006. – 307 с.Dikov I.N. Infectious diseases: textbook – Sofia; Znanie; 2006 (In Bulg.)Fagerhol MK, Dale I, Andersson T. Release and quantitation of a leucocyte derived protein (L1). Scandinavian Journal of Haematology 1980;24:393-398.Fagerhol MK, Dale I, Andersson T. Release and quantitation of a leucocyte derived protein (L1). Scandinavian Journal of Haematology 1980;24:393-398.Fabrizia D’Angeloa, Christian Felleyb, Jean Louis Frossarda. Calprotectin in Daily Practice: Where Do We Stand in 2017? Digestion 2017;95:293–301.Fabrizia D’Angeloa, Christian Felleyb, Jean Louis Frossarda. Calprotectin in Daily Practice: Where Do We Stand in 2017? Digestion 2017;95:293–301.Aguirre JD, Culotta VC. Battles with Iron: Manganese in Oxidative Stress Protection. The Journal of Biological Chemistry. 2012;287(17):13541-13548.Aguirre JD, Culotta VC. Battles with Iron: Manganese in Oxidative Stress Protection. The Journal of Biological Chemistry. 2012;287(17):13541-13548.Diaz-Ochoa VE, Lam D, Lee CS, et al. Salmonella mitigates oxidative stress and thrives in the inflamed gut by evading calprotectin-mediated manganese sequestration. Cell host & microbe. 2016;19(6):814-825.Diaz-Ochoa VE, Lam D, Lee CS, et al. Salmonella mitigates oxidative stress and thrives in the inflamed gut by evading calprotectin-mediated manganese sequestration. Cell host & microbe. 2016;19(6):814-825.Kehl-Fie TE, Chitayat S, Hood MI, et al. Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense enhancing neutrophil killing of Staphylococcus aureus. Cell host & microbe. 2011;10(2):158-164.Kehl-Fie TE, Chitayat S, Hood MI, et al. Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense enhancing neutrophil killing of Staphylococcus aureus. Cell host & microbe. 2011;10(2):158-164.Liang SC, Tan X-Y, Luxenberg DP, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. The Journal of Experimental Medicine. 2006;203(10):2271-2279.Liang SC, Tan X-Y, Luxenberg DP, et al. Interleukin (IL)- 22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. The Journal of Experimental Medicine. 2006;203(10):2271-2279.Lasson, Anders. Fecal calprotectin – the usefulness in special clinical situations and issues on the sampling procedure [Doctoral thesis]. University of Gothenburg. Sahlgrenska Academy. Institute of Medicine. Department of Internal Medicine; 2014. 81 p.Lasson, Anders. Fecal calprotectin – the usefulness in special clinical situations and issues on the sampling procedure [Doctoral thesis]. University of Gothenburg. Sahlgrenska Academy. Institute of Medicine. Department of Internal Medicine; 2014. 81 p.Tibble JA, Sigthorsson G, Bridger S, Fagerhol MK, Bjarnason I: Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology 2000;119:15–22.Tibble JA, Sigthorsson G, Bridger S, Fagerhol MK, Bjarnason I: Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology 2000;119:15–22.Joshi S, Lewis S, Creanor S, Ayling R: Agerelated faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers. Ann Clin Biochem 2010;47(pt 3): 259– 263.Joshi S, Lewis S, Creanor S, Ayling R: Agerelated faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers. Ann Clin Biochem 2010;47(pt 3): 259–263.Shastri YM, Bergis D, Povse N, Schäfer V, Shastri S, Weindel M, Ackermann H, Stein J: Prospective multicenter study evaluating fecal calprotectin in adult acute bacterial diarrhea. Am J Med 2008;121:1099–1106.Shastri YM, Bergis D, Povse N, Schäfer V, Shastri S, Weindel M, Ackermann H, Stein J: Prospective multicenter study evaluating fecal calprotectin in adult acute bacterial diarrhea. Am J Med 2008;121:1099–1106.Sýkora, Josef et al. Evaluation of Faecal Calprotectin as a Valuable Non-Invasive Marker in Distinguishing Gut Pathogens in Young Children with Acute Gastroenteritis. Acta Paediatrica 99.9 (2010): 1389–1395.Sýkora, Josef et al. Evaluation of Faecal Calprotectin as a Valuable Non- Invasive Marker in Distinguishing Gut Pathogens in Young Children with Acute Gastroenteritis. Acta Paediatrica 99.9 (2010): 1389–1395.Кессаева, И.К. Информативность фекального кальпротектина в диагностике острых кишечных инфекций у детей / И.К. Кессаева [и др.] // Фундаментальные исследования. – 2015. – № 1–1. – С. 87–91.Kessaeva I.K., Kaloeva Z.D., Barycheva L.Y., Golubeva M.V. Information of fecal calprotectin in the diagnosis of acute intestinal infections in children. Fundamental research. 2015. – № 1-1: 87-91.Chen, Chien-Chang; Huang, Jing-Long; Chang, Chee-Jen; Kong, Man-Shan; Fecal Calprotectin As A Correlative Marker In Clinical Severity of Infectious Diarrhea And Usefulness In Evaluating Bacterial or Viral Pathogens In Children. Journal of Pediatric Gastroenterology and Nutrition: November 2012 – Volume 55 – Issue 5 – p 541–547Chen, Chien-Chang; Huang, Jing-Long; Chang, Chee-Jen; Kong, Man-Shan; Fecal Calprotectin As A Correlative Marker In Clinical Severity of Infectious Diarrhea And Usefulness In Evaluating Bacterial or Viral Pathogens In Children. Journal of Pediatric Gastroenterology and Nutrition: November 2012 – Volume 55 – Issue 5 – p 541–547Lessa FC, Mu Y, Bamberg WM, Beldavs ZG, Dumyati GK, Dunn JR, et al.; Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015; 372(9):825–834.Lessa FC, Mu Y, Bamberg WM, Beldavs ZG, Dumyati GK, Dunn JR, et al.; Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015; 372(9):825–834.Debast, S.B. et al.; European Society of Clinical Microbiology and Infectious Diseases: Update of the Treatment Guidance Document for Clostridium difficile Infection; Clinical Microbiology and Infection , Volume 20 , 1 – 26.Debast, S.B. et al.; European Society of Clinical Microbiology and Infectious Diseases: Update of the Treatment Guidance Document for Clostridium difficile Infection; Clinical Microbiology and Infection , Volume 20 , 1 – 26.Kim, Jieun et al.; Fecal Calprotectin Level Reflects the Severity of Clostridium Difficile Infection; Annals of Laboratory Medicine 37.1 (2017): 53–57.Kim, Jieun et al.; Fecal Calprotectin Level Reflects the Severity of Clostridium Difficile Infection; Annals of Laboratory Medicine 37.1 (2017): 53–57.He M, Miyajima F, Roberts P, et al. Emergence and global spread of epidemic healthcare- associated Clostridium difficile. Nature genetics. 2013;45(1):109-113.He M, Miyajima F, Roberts P, et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature genetics. 2013;45(1):109-113.Peretz A, Tkhawkho L, Pastukh N, Brodsky D, Halevi CN, Nitzan O. Correlation between fecal calprotectin levels, disease severity and the hypervirulent ribotype 027 strain in patients with Clostridium difficile infection. BMC Infectious Diseases. 2016;16:309.Peretz A, Tkhawkho L, Pastukh N, Brodsky D, Halevi CN, Nitzan O. Correlation between fecal calprotectin levels, disease severity and the hypervirulent ribotype 027 strain in patients with Clostridium difficile infection. BMC Infectious Diseases. 2016;16:309.

The authors declare that there are no conflicts of interest present.