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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2018-10-1-29-35</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-691</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ПРИВЕРЖЕННОСТИ АНТИРЕТРОВИРУСНОЙ ТЕРАПИИ У БОЛЬНЫХ ВИЧ-ИНФЕКЦИЕЙ, УПОТРЕБЛЯЮЩИХ АЛКОГОЛЬ</article-title><trans-title-group xml:lang="en"><trans-title>ASSESMENT OF ADHERENCE TO ARVT IN HIV-POSITIVE PATIENTS WITH ALCHOHOL ABUSE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovlev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий кафедрой</p><p>кафедра инфекционных болезней, эпидемиологии и дерматовенерологии</p><p>медицинский факультет</p><p>д.м.н., профессор;</p><p>тел.: 8(812)717-28-48</p></bio><email xlink:type="simple">aay28@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дьячков</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Diachkov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент</p><p>кафедра инфекционных болезней и эпидемиологии</p><p>врач-инфекционист</p><p>тел.: 8(812)409-79-62</p></bio><email xlink:type="simple">cd4@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мусатов</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Musatov</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доцент</p><p>кафедра инфекционных болезней, эпидемиологии и дерматовенерологии</p><p>медицинский факультет</p><p>к.м.н.</p><p>тел.: 8(812)717-77-61</p></bio><email xlink:type="simple">doctormusatov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Айзсилниекс</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ayzsilnieks</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший лаборант</p><p>кафедра инфекционных болезней и эпидемиологии </p><p>тел.: 8(812)338-70-58 </p></bio><email xlink:type="simple">oksanaayzsilnieks@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стреляная</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Strelyanaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-нарколог </p><p>тел.: 8(812)409-79-62 </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдошина</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Avdoshina</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор</p><p>кафедра инфекционных болезней, эпидемиологии и дерматовенерологии</p><p>медицинский факультет </p><p>тел.: 8(812)717-77-61</p></bio><email xlink:type="simple">darja_mikhailovich@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Staint-Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова;  &#13;
Клиническая инфекционная больница имени С.П. Боткина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Saint-Petersburg State Medical University named after academician I.P. Pavlov;  &#13;
Clinical Infectious Diseases Hospital named after S.P. Botkin</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Saint-Petersburg State Medical University named after academician I.P. Pavlov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Клиническая инфекционная больница имени С.П. Боткина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Infectious Diseases Hospital named after S.P. Botkin</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>04</month><year>2018</year></pub-date><volume>10</volume><issue>1</issue><fpage>29</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Яковлев А.А., Дьячков А.Г., Мусатов В.Б., Айзсилниекс О.В., Стреляная Е.В., Авдошина Д.Д., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Яковлев А.А., Дьячков А.Г., Мусатов В.Б., Айзсилниекс О.В., Стреляная Е.В., Авдошина Д.Д.</copyright-holder><copyright-holder xml:lang="en">Yakovlev A.A., Diachkov A.G., Musatov V.B., Ayzsilnieks O.V., Strelyanaya E.V., Avdoshina D.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/691">https://journal.niidi.ru/jofin/article/view/691</self-uri><abstract><sec><title>Цель</title><p>Цель: изучить распространенность употребления алкоголя и оценить влияние злоупотребления алкоголем на приверженность антиретровирусной терапии у ВИЧ-инфицированных больных.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: проведено анонимное анкетирование 165 больных ВИЧ-инфекцией, находившихся на лечении в Клинической инфекционной больнице им. С.П. Боткина в 2017 г.</p></sec><sec><title>Результаты</title><p>Результаты: более половины больных обследованной группы отмечали опасное употребление или злоупотребление алкоголем. Для ВИЧ-позитивных больных, употребляющих алкоголь, был характерен высокий уровень алкогольной анозогнозии. Среди госпитализированных больных, не получавших антиретровирусной терапии на момент госпитализации, 57%, по данным тестирования, не были готовы к началу приема антиретровирусных препаратов. Пациенты, которые получали антиретровирусную терапию на момент проведения исследования, в 92% случаев имели опыт прерывания терапии в прошлом. Самой частой причиной прерывания антиретровирусной терапии участники исследования назвали побочные действия препаратов (36,5%). С употреблением алкоголя прерывание терапии связали 7,7% опрошенных. Уровень приверженности статистически значимо различался у больных с разной степенью алкоголизации. Результаты различных шкал самооценки приверженности свидетельствуют о недостаточной приверженности антиретровирусной терапии среди госпитализированных больных ВИЧ-инфекцией.</p></sec><sec><title>Заключение</title><p>Заключение: среди госпитализированных больных ВИЧ-инфекцией широко распространены опасное употребление алкоголя и алкогольная зависимость. Предложенные методики самооценки приверженности могут помочь врачам выявить группы с потенциально недостаточным уровнем приверженности антиретровирусной терапии. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to analyze prevalence of alcohol abuse and influence of alcohol abuse on adherence to ARVT in HIV-positive patients.</p></sec><sec><title>Research materials</title><p>Research materials: we performed an anonymous survey of 165 HIV-positive patients hospitalized in Clinical Infectious Diseases Hospital named after S.P. Botkin in 2017.</p></sec><sec><title>Results</title><p>Results: more than a half of participants has hazardous alcohol use or alcohol dependence. HIV-positive patients with alcohol abuse have high level of alcohol anosognosia. According to our survey among hospitalised patients, who didn’t take ARVT, 57% wasn’t ready to start antiretroviral therapy. Among patients, who were on ARVT at the time of evaluation, 92% had history of at least one episode of treatment interruption. Most common reason for interruption of antiretroviral therapy was drug’s side effect (36,5%). Alcohol was mentioned as a cause of interruption by 7,7% of participants. Level of adherence was significantly different among patients with different alcohol consumption pattern. Adherence measured with different self-assessment tools was low among hospitalized HIV-positive patients.</p></sec><sec><title>Conclusion</title><p>Conclusion: Hazardous drinking and alcohol dependence is very common among hospitalized HIV-positive patients. Suggested adherence self-assessment tools should help doctors to detect patients with insufficient level of adherence to ARVT. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ВИЧ-инфекция</kwd><kwd>алкогольная зависимость</kwd><kwd>АРВТ</kwd><kwd>приверженность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>HIV</kwd><kwd>alcohol abuse</kwd><kwd>ARVT</kwd><kwd>adherence</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 17-56- 30026.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ладная, Н.Н. 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