jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2017-9-3-117-128jofin-641Research ArticleДискуссииDiscussionsОСЛОЖНЕНИЯ ВЕТРЯНОЙ ОСПЫ (обзор литературы )COMPLICATIONS OF CHICKENPOX (LITERATURE REVIEW)ЗрячкинН. И.ZryachkinN. I.nizryach@yandex.ruБучковаТ. Н.BuchkovaT. N.buchkova.t@mail.ruЧеботареваГ. И.ChebotarevaG. I.Саратовский государственный медицинский университет имени В.И. РазумовскогоРоссияSaratov State Medical University named after V.I. RazumovskyRussian Federation20171310201793117128Copyright © Зрячкин Н.И., Бучкова Т.Н., Чеботарева Г.И., 20172017Зрячкин Н.И., Бучкова Т.Н., Чеботарева Г.И.Zryachkin N.I., Buchkova T.N., Chebotareva G.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/641

В обзоре представлены данные российских и зарубежных авторов о широко распространенных и часто диагностируемых, а также редких клинических формах осложнений VZV-инфекции. Приводятся данные о частоте и структуре осложнений. Выделяются группы риска осложненного течения ветряной оспы. Учитывая впервые представленные в литературе сведения, предлагается классификация осложнений ветряной оспы. Приведены данные по значительному снижению частоты развития осложнений, показателей заболеваемости, смертности, экономических потерь в странах, внедривших массовую иммунопрофилактику ветряной оспы.

The review presents the data of Russian and foreign authors about the widespread and often under-diagnosed, as well as rare clinical forms of complications of VZV infection. Provides data on the frequency and structure of complications. There are groups risk of complications during varicella. Given the information first presented in the literature information classification of complications of chickenpox. The data on significant reduction in the frequency of complications, morbidity, mortality, economic losses in countries that have implemented mass immunization against varicella.

ветряная оспаосложнениядетиvaricellacomplicationschildrenReferencesМедицинская вирусология : руководство / под ред. Д.К. Львова. – М.: МИА, 2008. – 656 с.L’vov D.K., ed. Medical Virology: Rukovodstvo. M.: MIA; 2008: 656 (In Russian).Селькова, Е.П. Эпидемиология ветряной оспы / Е.П. Селькова // Бюллетень "Вакцинация". – 2009. – №1. – С. 5–7.Sel’kova E.P. Byulleten’ “Vakcinaciya”. 2009; 1:5-7 (In Russian).Баранов, А.А. Предотвращение ветряной оспы средствами специфической профилактики в Беларуси, Казахстане, России и Украине (заявление группы экспертов в области вакцинопрофилактики) / А.А. Баранов [и др.] // Педиатрическая фармакология. – 2008. – Т. 5, № 3. – С. 6-14.Baranov A.A., Balashov D.N., Gorelov A.V. et al. Pediatricheskaya farmakologiya. 2008; 5(3):6-14 (In Russian).Gnann J., Whitley T. Clinical practise: herpes zoster. N.Engl. J. Med. 2002; 347: 340-346.Gnann J and Whitley T. Clinical practise: herpes zoster. N. Engl. J. Med. 2002; 347: 340-346.Таточенко, В.К. Ветряная оспа – клиническая картина / В.К. Таточенко // Бюллетень "Вакцинация". – 2009. – №1. – С. 5–6.Tatochenko V.K. Byulleten’ vakcinaciya. 2009;1:5-6 (In Russian).Ясинский, А.А. Ветряная оспа в Российской Федерации / А.А. Ясинский // Бюллетень "Вакцинация". – 2009. – №1. – С. 3.Yasinskij A.A. Byulleten’ vakcinaciya. 2009;1:3 (In Russian).Государственный доклад«О состоянии санитарноэпидемиологического благополучия населения в Российской Федерации в 2015 году». – http://rospotrebnadzor.ru/documents/details.phpGosudarstvennyj doklad “On the state sanitary and epidemiological wellbeing of the population in the Russian Federation in 2015”. http://rospotrebnadzor.ru/documents/details.php (In Russian).Государственный доклад "О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2016 году". – http://rospotrebnadzor.ru/documents/details.phpGosudarstvennyj doklad “On the state sanitary and epidemiological wellbeing of the population in the Russian Federation in 2016”. http://rospotrebnadzor.ru/documents/details.php (In Russian).Баликин, В.Ф. Расширение клинического полиморфизма и нарастание тяжести инфекции Varicella zoster у детей / В.Ф. Баликин, М.С. Философова // Материалы XIII Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики». – М., 2014. – С.8.Balikin V.F, Filosofova M.S. [Extension of the portmanteau and the clinical severity of the infection Varicella zoster in children]. In.: Materialy XIII Kongressa detskih infekcionistov Rossii «Aktual’nye voprosy infekcionnoj patologii i vakcinoprofilaktiki « [ Proceedings of the XIII Congress of pediatric infectious disease physicians of Russia “Urgent issues of infectious diseases and vaccination”]. M.: 2014:8 (In Russian).Chiappini E. et all. Varicella-zoster virus acquired of 4 months of age reactivates of 24-4 months and causes encephalitis. J. Pediatr. 2002;140(2):250-251.Chiappini E. et all. Varicella-zoster virus acquired of 4 months of age reactivates of 24-4 months and causes encephalitis. J. Pediatr. 2002; 140(2):250-251.Шаханина, И.Л. Экономическая оценка вакцинопрофилактики ветряной оспы на примере Москвы / И.Л. Шаханина [и др.] // Эпидемиология и инфекционные болезни. – 2009. – Т. 3, № 2. – С. 49–56.Shahanina I.L., Gorelov A.V., Lytkina I.N. et al. Ehpidemiologiya i infekcionnye bolezni. 2009;3(2):49-56 (In Russian).Идрисова, Ж.Р. Новые аспекты патогенеза и стандарт диагностики вирусных энцефалитов у детей : аавтореф. дис….д-ра мед. наук / Ж.Р. Идрисова. – М.: 2001. – 36 с.Idrisova ZH.R. New aspects of pathogenesis and the standard for the diagnosis of viral encephalitis in children [New aspects of pathogenesis and the standard for the diagnosis of viral encephalitis in children] Avtoref. diss. d.m.n. M., 2001: 36 (In Russian).Nathwani D., Maclean A., Conway S. et al. Varicella infections in pregnancy and the newborn. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. J Infect. 1998;36 (Suppl 1):59-71.Nathwani D., Maclean A., Conway S., et al. Varicella infections in pregnancy and the newborn. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. J Infect. 1998;36 (Suppl 1):59-71.National Advisory Committee on Immunization (NACI) update on varicella. Can. Commun. Dis. Rep. 2004;30:1-26.National Advisory Committee on Immunization (NACI) update on varicella. Can. Commun. Dis. Rep. 2004;30:1-26.Михайлова, Е.В. Ветряная оспа у новорожденных: симптомы, осложнения, современные методы терапии и профилактики / Е.В. Михайлова [и др.] // Материалы XIII Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики». –М., 2014. –С. 48–9.Mihajlova E.V., Kashchaev B.A., Il’icheva T.G., Budarina YU.S. Vetrjanaja ospa u novorozhdennyh: simptomy, oslozhnenija, sovremennye metody terapii i profilaktiki. [Chickenpox in newborns: symptoms, complications, modern methods of therapy and prevention]. In: Materialy XIII Kongressa detskih infekcionistov Rossii «Aktual’nye voprosy infekcionnoj patologii i vakcinoprofilaktiki» [Proceedings of the XIII Congress of pediatric infectious disease physicians of Russia “Urgent issues of infectious diseases and vaccination”]. M.: 2014: 48-49 (In Russian).Gershon A.A., Takahashi M., Seward J. Varicella vaccine In: Vaccines, Plotkin S.A., Orenstein W.A., Offit P.A., eds. Pennsylvania: W.B. Saunders. 2004:783-823.Gershon A.A., Takahashi M., Seward J. Varicella vaccine In: Vaccines, Plotkin S.A., Orenstein W.A., Offit P.A., eds. Pennsylvania: W.B. Saunders, 2004:783-823.Jura E., Chadwick E.G., Josephs S.H. et al. Varicella-zoster virus infections in children infected with human immunodeficiency virus. Pediatr. Infect. Dis. J. 1989;8:586-590.Jura E., Chadwick E.G., Josephs S.H., et al. Varicellazoster virus infections in children infected with human immunodeficiency virus. Pediatr. Infect. Dis. J. 1989;8:586-590.Hill G, Chauvenet A, Lovato J, McLean T. Recent steroid therapy increases severity of varicella infections in children with acute lymphoblastic leukemia. Pediatrics. 2005;116(4):525-529.Hill G, Chauvenet A, Lovato J, McLean T. Recent steroid therapy increases severity of varicella infections in children with acute lymphoblastic leukemia. Pediatrics. 2005;116(4):525529.Giacchino R., Marcellini M., Timitilli A. et al. Varicella vaccine in children requiring renal or hepatic transplantation. Transplantation. 1995;60(9):1055-1156.Giacchino R., Marcellini M., Timitilli A., et al. Varicella vaccine in children requiring renal or hepatic transplantation. Transplantation. 1995;60(9):1055-1156.Preplud S.R. Age specific risks of varicella complications. Pediatrics. 1981;68:14-17.Preplud S.R. Age specific risks of varicella complications. Pediatrics. 1981;68:14-17.Тихонова, Е.П. Ветряная оспа у взрослых / Е.П. Тихонова [и др.] // Журнал инфектологии. Материалы первого конгресса Евро-Азиатского общества по инфекционным болезням. –2010. –Т. 2, № 4. –С.114.21 Tihonova E. P. Tihonova YU. S., Kuz’mina et al. Vetrjanaja ospa u vzroslyh. [Chickenpox in adults]. ZHurnal infektologii. Materialy pervogo kongressa EvroAziatskogo obshchestva po infekcionnym boleznyam [Journal of Infectology. Proceedings of the first Congress of Euro-Asian society for infectious diseases.]. 2010; 2(4):114 (In Russian).Mohsen A., Mc Kendrick M. Varicella pneumonia in adults. Eur. Respir. J. 2003;21:886-891.Mohsen A., Mc Kendrick M. Varicella pneumonia in adults. Eur. Respir. J. 2003;21:886-891.Abro A., Ustadi A. M., Das K., Abdou A. M., Hussaini H. S., Chandra F. S. Chickenpox: presentation and complications in adults. J. Pak. Med. Assoc. 2009;59(12):828-831.Abro A., Ustadi A. M., Das K., Abdou A. M., Hussaini H. S., Chandra F. S. Chickenpox: presentation and complications in adults. J. Pak. Med. Assoc. 2009;59(12):828-831.Маркосьян, Н.С. Поражение нервной системы при «детских воздушно-капельных инфекций» у взрослых / Н.С. Маркосьян [и др.] // Материалы XIII Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики». –М., 2014. –С. 45.Markos’yan N.S., YUrlova YU.YU., Filatova T.V., CHekmaeva I.I. Porazhenie nervnoj sistemy pri «detskih vozdushnokapel’nyh infektsij» u vzroslyh. Porazhenie nervnoj sistemy pri «detskih vozdushno-kapel’nyh infektsij» u vzroslyh. [The defeat of the nervous system in the “children’s respiratory infections” in adults. In: Materialy XIII Kongressa detskih infekcionistov Rossii «Aktual’nye voprosy infekcionnoj patologii i vakcinoprofilaktiki» [Proceedings of the VII annual all-Russian Congress on infectious diseases with international participation]. M.; 2014: 45 (In Russian).Хохлова, З.А. Генерализованная форма ветряной оспы / З.А. Хохлова, Ю.М. Кириллова // Материалы VII ежегодного Всероссийского Конгресса по инфекционным болезням с международным участием. –М., 2015. –С. 356.Hohlova Z.A., Kirillova YU.M. Generalizovannaja forma vetrjanoj ospy. Generalizovannaja forma vetrjanoj ospy. [Generalized form of chicken pox]. In: Materialy VII ezhegodnogo Vserossijskogo Kongressa po infekcionnom boleznyam s mezhdunarodnym uchastiem [Proceedings of the VII annual all-Russian Congress on infectious diseases with international participation]. M.; 2015:356 (In Russian).Илунина, Т.И. Ветряная оспа у взрослых / Т.И. Илунина, А.Г. Гукасян, Ю.А. Бережная // Материалы VII ежегодного Всероссийского Конгресса по инфекционном болезням с международным участием. –М., 2015. –С. 138.Ilunina T.I., Gukasyan A.G. Berezhnaya YU.A. Vetrjanaja ospa u vzroslyh. [Chickenpox in adults]. In.: Materialy VII ezhegodnogo Vserossijskogo Kongressa po infekcionnom boleznyam s mezhdunarodnym uchastiem [Proceedings of the VII annual all-Russian Congress on infectious diseases with international participation]. М.; 2015: 138 (In Russian).Banz K., Wagenpfeil S., Neiss A. et al. The burden of varicella in Germany: potential risks and economic impact. Eur. J. Health. Econom. 2004; 5:546-553.Banz K., Wagenpfeil S., Neiss A., et al. The burden of varicella in Germany: potential risks and economic impact. Eur. J. Health. Econom. 2004; 5: 546-553.Liuse J.G., Groute V., Rosenfeld E. et al. The burden of varicella complications before the introduction of routine varicella vaccination in Germany. Pediatr infect Dis. 2008; 27(2):119-124.Liuse J.G., Groute V., Rosenfeld E., et al. The burden of varicella complications before the introduction of routine varicella vaccination in Germany. Pediatr infect Dis. 2008; 27(2):119-124.Meyer P.A., Seward J.F., Jumaan A.O. et al. Varicella mortality: trends before vaccine licensure in the United States, 1970-1994. J. Infect. 2000; 182:383-390.Meyer P.A., Seward J.F., Jumaan A.O., et al. Varicella mortality: trends before vaccine licensure in the United States, 1970-1994. J. Infect. 2000; 182:383-390.Galil K., Brown C., Lin F. et al. Hospitalisations for varicella in the United States, 1988 to 1999. Pediatr. Infect. Dis. J. 2002; 21:931-934.Galil K., Brown C., Lin F., et al. Hospitalisations for varicella in the United States, 1988 to 1999. Pediatr. Infect. Dis. J. 2002; 21:931-934.WHO. World Health Organization. Wkly Epidemiol Rec. 2014; 89:265-287.WHO. World Health Organization. Wkly Epidemiol Rec. 2014; 89:265-287.Кочергина, Е.А. Современные особенности клинических проявлений ветряной оспы / Е.А. Кочергина, Р.Н. Трефилов // Материалы XIII Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики». –М., 2014. –С. 37.Kochergina E.A., Trefilov R.N. Sovremennye osobennosti klinicheskih projavlenij vetrjanoj ospy [The modern features of clinical manifestations of varicella]. In: Materialy XIII Kongressa detskih infekcionistov Rossii «Aktual’nye voprosy infekcionnoj patologii i vakcinoprofilaktiki» [Proceedings of the XIII Congress of pediatric infectious disease physicians of Russia “Urgent issues of infectious diseases and vaccination”]. M.; 2014:37 (In Russian).Dubos F., Grandbastien B., Hue V. et al. Epidemiology of hospital admissions for paediatric varicella infections: a oneyear prospective survey in the pre-vaccine era. Epidemiol. Infect. 2007; 135:131-138.Dubos F., Grandbastien B., Hue V., et al. Epidemiology of hospital admissions for paediatric varicella infections: a oneyear prospective survey in the pre-vaccine era. Epidemiol. Infect. 2007; 135:131-138.Bonsignori F., Chiappini E., Frenos S. et al. Hospitalization rates for complicated and uncomplicated chickenpox in a poorly vaccined pediatric population. Infection. 2007; 35:444-450.Bonsignori F., Chiappini E., Frenos S., et al. Hospitalization rates for complicated and uncomplicated chickenpox in a poorly vaccined pediatric population. Infection. 2007; 35:444-450.Theodoridou M., Laina I, Hadjichristodoulou C. et al. Varicella-related complications and hospitalisations in a tertiary pediatric medical center before vaccine introduction. Eur. J. Pediatr. 2006; 165:273-274.Theodoridou M., Laina I, Hadjichristodoulou C., et al. Varicella-related complications and hospitalisations in a tertiary pediatric medical center before vaccine introduction. Eur. J. Pediatr. 2006; 165:273-274.Cameron J.C., Allan G., Johnston F. et al. Severe complications of chickenpox in hospitalised children in the UK and Ireland. Arch. Dis. Child. 2007; 92(2):1062-1066.Cameron J.C., Allan G., Johnston F., et al. Severe complications of chickenpox in hospitalised children in the UK and Ireland. Arch. Dis. Child. 2007; 92(2):1062-1066.Mallet E., Maitre M., Delalande-Dutilleul L., Marguet C., Mouterde O. Evaluation of varicella complications through a retrospective hospital survey in a paediatric center over 16 years in France. Arch Pediatr. 2004 Sep;11(9):1145-1151.Mallet E., Maitre M., Delalande-Dutilleul L., Marguet C., Mouterde O. Evaluation of varicella complications through a retrospective hospital survey in a paediatric center over 16 years in France. Arch Pediatr. 2004 Sep;11(9):1145-1151.Ziebold C., von Kries R., Lang R., Weigl J., Schmitt H.J. Severe complications of varicella in previously healthy children in Germany: a 1-year survey. Pediatrics. 2001 Nov; 108(5):E79.Ziebold C., von Kries R., Lang R., Weigl J., Schmitt H.J. Severe complications of varicella in previously healthy children in Germany: a 1-year survey. Pediatrics. 2001 Nov; 108(5):E79.Bonhoeffer J et al. Complications of varicella in previously healthy children (Sweden). Eur J Pediatr. 2005; 164:366-370.Bonhoeffer J et al. Complications of varicella in previously healthy children (Sweden). Eur J Pediatr 2005; 164:366-370.DulovićO., GvozdenovićE., NikolićJ., SpurnićA. R., KatanićN., Kovarević-PavićevićD. Varicella complications: is it time to consider a routine varicella vaccination? Vojnosanit Pregl. 2010;67(7):523-529.Dulović O., Gvozdenović E., Nikolić J., Spurnić A. R., Katanić N., Kovarević-Pavićević D. Varicella complications: is it time to consider a routine varicella vaccination? Vojnosanit Pregl. 2010;67(7):523-529.Almuneef M., Memish Z.A, Balkhy H.H., Alotaibi B., Helmy M. Chickenpox complications in Saudi Arabia: Is it time for routine varicella vaccination? Int J. Infect Dis. 2006 Mar;10(2):156-61.Almuneef M., Memish Z.A, Balkhy H.H., Alotaibi B., Helmy M. Chickenpox complications in Saudi Arabia: Is it time for routine varicella vaccination? Int J. Infect Dis. 2006 Mar;10(2):156-161.Van Lier A., van der Maas N.A., Rogerburg G.D., Sanders E.A., de Meiker H.E. Hospitalization due to varicella in the Netherlands. BMC Infect. Dis. 2011;11:85.Van Lier A., van der Maas N.A., Rogerburg G.D., Sanders E.A., de Meiker H.E. Hospitalization due to varicella in the Netherlands. BMC Infect. Dis. 2011;11:85.Blumental S., Sabbe M., Lepage P. Belgian Group for Varicella. Varicella paediatric hospitalisations in Belgium: a 1-year national survey. Arch Dis Child. 2016 Jan;101(1):16-22. doi: 10.1136/archdischild-2015-308283. Epub 2015 Jun 30.Blumental S., Sabbe M., Lepage P. Belgian Group for Varicella. Varicella paediatric hospitalisations in Belgium: a 1-year national survey. Arch Dis Child. 2016 Jan;101(1):16-22. doi: 10.1136/archdischild-2015-308283. Epub 2015 Jun 30.Лобзин, Ю.В. Научно-исследовательская деятельность научно-исследовательского института детских инфекций ФМБА России в условиях модернизации здравоохранения (по итогам работ учреждения в 2014 г.) / Ю.В. Лобзин, Н.В. Скрипченко, В.М. Волжанин // Журнал инфектологии. Приложение. Материалы Всероссийского ежегодного конгресса «Инфекционные болезни у детей: диагностика, лечение и профилактика». Санкт-Петербург, 9–10 октября 2015 года.–2015. – Т. 7, № 4. – С. 10–12.Lobzin YU.V., Skripchenko N.V., Volzhanin V.M. ZHurnal infektologii. Prilozhenie. 2015; 7(4):10-12 (In Russian).Тимченко, В.Н. Лечение и профилактика ветряной оспы у детей в современных условиях : методические рекомендации / В.Н. Тимченко. – СПб., 2008. – 32 с.Timchenko V.N. Treatment and prevention of varicella in children in modern conditions: S-Pb; 2008: 32 (In Russian).Куватов, С.С. Случай гангренозной формы ветряной оспы у больного 9 лет / С.С. Куватов [и др.] // Детский врач. – 2008. – № 6. – С. 11–13.Kuvatov S. S., Kuvatova N. D., Lyupova N. G. et al. Detskij vrach. 2008; 6: 11-13 (In Russian).Илунина, Л.М. Ветряная оспа у детей / Л.М. Илунина [и др.] // Журнал инфектологии. Приложение. Материалы Всероссийского ежегодного конгресса «Инфекционные болезни у детей: диагностика, лечение и профилактика». Санкт-Петербург, 9–10 октября 2015 года. – 2015. – Т. 7, № 4. – С.75–76.Ilunina L.M., Agisheva L.A., Berezhnaya YU.A., Radchenko O.M. ZHurnal infektologii. Prilozhenie. 2015; 7(4):7576 (In Russian).Калачев, У.А. Вирусно-бактериальная ассоциация при ветряной оспе у детей / У.А. Калачев, Д.А. Валишин, В.Б. Егоров // Журнал инфектологии. Приложение. Материалы Всероссийского ежегодного конгресса «Инфекционные болезни у детей: диагностика, лечение и профилактика». Санкт-Петербург, 9–0 октября 2015 года. –2015. –Т. 7, № 4. –С.76–7.Kalachev U.A., Valishin D.A, Egorov V.B. ZHurnal infektologii. Prilozhenie. 2015; 7(4):76-77 (In Russian).Балашов, Д.Н. Вакцинация против ветряной оспы иммунокомпроментированных пациентов. Вопросы гематологии и иммунологии в педиатрии. –2011. –Т. 10, № 4. –С. 3–.Balashov D.N. Voprosy gematologii i immunologii v pediatrii. 2011; 10 (4): 3-9 (In Russian).Yilmaz C., Gaksen H. Severe neurological complications of chickenpox. Eur. J. Gen. Med. 2005; 2(4):177-179.Yilmaz C., Gaksen H. Severe neurological complications of chickenpox. Eur. J. Gen. Med. 2005; 2(4):177-179.Скрипченко, Е.Ю. Неврологические осложнения и прогноз их развития при ветряной оспе у детей: автореф. дис…. канд. мед. наук / Е.Ю. Скрипченко. –СПб., 2013. – 23 с.Skripchenko E.YU. Neurological complications and prognosis of their development chickenpox in children [Neurological complications and prognosis of their development chickenpox in children]. Avtoref. diss….kand. med.scien.… .Spb., 2013:23 (In Russian).Ветряная оспа у детей : руководство для врачей / под ред. Н.В. Скрипченко. –СПб: Тактик-Студио, 2015. –296 с.Skripchenko. N.V. Chickenpox in children. SPb: TaktikStudio. 2015:296 (In Russian).Тимченко, В.Н. Воздушно-капельные инфекции в практике педиатра и семейного врача : руководство для врачей / В.Н. Тимченко. –СПб: ЭЛСБИ, 2007. –631 с.Timchenko V.N. Airborne infection in the practice of pediatrician and family physician. EHLSBI-SPb; 2007: 631 (In Russian).Денисенко, В.Б. Современные клинико-лабораторные особенности ветряночных энцефалитов у детей / В.Б. Денисенко [и др.] // Журнал инфектологии. Приложение. Материалы Всероссийского ежегодного конгресса «Инфекционные болезни у детей: диагностика, лечение и профилактика». Санкт-Петербург, 9–0 октября 2015 года. – 2015. –Т. 7, № 4. –С. 66–7.Denisenko V.B., Simov’yan EH.N., EHl’kanova S.D., Rubcov N.S. ZHurnal infektologii. Prilozhenie. 2015; 7(4):66-67 (In Russian).Biesiada G., Czepielb J., Sobczyk-Krupiarzb I., Machb T., Garlicki Przegl A. Neurological complications among patients with zoster hospitalized in Department of Infectious Diseases in Cracow in 2001–006. Lek. 2010;67(3):149-150.Biesiada G., Czepielb J., Sobczyk-Krupiarzb I., Machb T., Garlicki Przegl A. Neurological complications among patients with zoster hospitalized in Department of Infectious Diseases in Cracow in 2001–2006. Lek. 2010;67(3):149-150.Pahud B. A., Glaser C. A., Dekker C. L., Arvin A. M., Schmid D. S. Varicella zoster disease of the central nervous system: epidemiological, clinical, and laboratory features 10 years after the introduction of the varicella vaccine. J. Infect. Dis. 2011;203 (3):316-323. Серія «Медицина». Випуск 24 97.Pahud B. A., Glaser C. A., Dekker C. L., Arvin A. M., Schmid D. S. Varicella zoster disease of the central nervous system: epidemiological, clinical, and laboratory features 10 years after the introduction of the varicella vaccine. J. Infect. Dis. 2011;203 (3):316-323. Серія «Медицина». Випуск 24 97.Ратьева, И.А. Поражение ЦНС при ветряной оспе у детей в Астраханской области / И.А. Ратьева [и др.] // Материалы XIII Конгресса детских инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики». –М., 2014. –С. 60.Rat’eva I.A, Kolokolov V.A., Nazarochkina O.V., CHanpalova L.S. et al. Porazhenie TsNS pri vetrjanoj ospe u detej v Astrahanskoj oblasti [CNS varicella in children in the Astrakhan region]. In: Materialy XIII Kongressa detskih infekcionistov Rossii «Aktual’nye voprosy infekcionnoj patologii i vakcinoprofilaktiki « [Proceedings of the XIII Congress of pediatric infectious disease physicians of Russia “Urgent issues of infectious diseases and vaccination”]. M.; 2014:60 (In Russian).Meijide H., Freire S., Vega P., Carcia-Martin C. Meningoencephalitis due to varicella zoster virus: an uncommon problem of acute confusional syndrome in the elderly. Enferm. Infecc. Microbiol Clin. 2011;29(8):632.Meijide H., Freire S., Vega P., Carcia-Martin C. Meningoencephalitis due to varicella zoster virus: an uncommon problem of acute confusional syndrome in the elderly. Enferm. Infecc. Microbiol Clin. 2011;29(8):632.Bangen K. J., Delano-Wood L., Wierenga C. E., Stricker N. H., Hesselink J. R., Bondi M. W. Dementia following herpes zoster encephalitis. Clin. Neuropsychol. 2010;24 (7):1193-1203.Bangen K. J., Delano-Wood L., Wierenga C. E., Stricker N. H., Hesselink J. R., Bondi M. W. Dementia following herpes zoster encephalitis. Clin. Neuropsychol. 2010;24 (7):1193-1203.Ben-Amor S., Lammouchi T., Benslamia L., Benammou S. Post varicella zoster virus myelitis in immunocompetent patients. Neurosciences (Riyadh). 2011;16(2):156-158.Ben-Amor S., Lammouchi T., Benslamia L., Benammou S. Post varicella zoster virus myelitis in immunocompetent patients. Neurosciences (Riyadh). 2011;16(2):156-158.Kennedy P. G., Cohrs R. J. Varicella-zoster virus human ganglionic latency: a current summary. J. Neurovirol. 2010;16 (6):411-418.Kennedy P. G., Cohrs R. J. Varicella-zoster virus human ganglionic latency: a current summary. J. Neurovirol. 2010;16 (6):411-418.Bessho M., Nakajima H., Ito T., Kitaoka H. Case of incomplete brown-Sequard syndrome after thoracic herpes zoster infection. Rinsho. Shinkeigaku. 2010; 50 (3):175-177.Bessho M., Nakajima H., Ito T., Kitaoka H. Case of incomplete brown-Sequard syndrome after thoracic herpes zoster infection. Rinsho. Shinkeigaku. 2010; 50 (3):175-177.Wassilew S. Skin involvement in zoster. Klein. Monbl. Augenheilkd. 2010; 227(5):375-378.Wassilew S. Skin involvement in zoster. Klein. Monbl. Augenheilkd. 2010; 227(5):375-378.Sanjay S., Huang P., Lavanya R. Herpes zoster ophthalmicus. Curr. Treat. Options Neurol. 2011;13(1):79-91.Sanjay S., Huang P., Lavanya R. Herpes zoster ophthalmicus. Curr. Treat. Options Neurol. 2011;13(1):79-91.Kawatani M., Nakai A., Okuno T., Tsukahara H., Ohshima Y., Mayumi M. A case of intracranial saccular aneurysm after primary varicella zoster virus infection. Brain Dev. 2012;34 (1):80-82.Kawatani M., Nakai A., Okuno T., Tsukahara H., Ohshima Y., Mayumi M. A case of intracranial saccular aneurysm after primary varicella zoster virus infection. Brain Dev. 2012;34 (1):80-82.Голева, О.В. Реактивация вируса Эпштейна –Барр при ветряночных энцефалитах / О.В. Голева, Е.А. Мурина, З.А. Осипова // Материалы VII ежегодного Всероссийского Конгресса по инфекционном болезням с международным участием. –М., 2015. –С. 91.Goleva O.V., Murina E.A, Osipova Z.A. Reaktivatsija virusa `Epshtejna-Barr pri vetrjanochnyh `entsefalitah. [Reactivation of Epstein-Barr encephalitis with vetrenny]. С-Пб. In: Materialy VII ezhegodnogo Vserossijskogo Kongressa po infekcionnom boleznyam s mezhdunarodnym uchastiem [Proceedings of the VII annual all-Russian Congress on infectious diseases with international participation]. М.; 2015: 91 (In Russian).Rack A. L., Grote V., Streng et al. Neurologic varicella complications before routine immunization in Germany Pediatr. Neurol. 2010; 42(1): 40-48.Rack A. L., Grote V., Streng et al. Neurologic varicella complications before routine immunization in Germany Pediatr. Neurol. 2010; 42(1): 40-48.De A., Myridakis D., Kerrigan M., Kiblawi F. Varicella myopericarditis mimicking myocardial infarction in a 17-yearold boy. Tex. Heart Inst. J. 2011;38 (3):288-290.De A., Myridakis D., Kerrigan M., Kiblawi F. Varicella myopericarditis mimicking myocardial infarction in a 17-yearold boy. Tex. Heart Inst. J. 2011;38 (3):288-290.Samyn B., Grunebaum L., Amiral J., Ammouche C., Lounis K., Eicher E. et al. Post-varicella cerebral thrombophlebitis with anti-protein S: report of a pediatric case. Ann. Biol. Clin. (Paris). 2012;70(1):99-103.Samyn B., Grunebaum L., Amiral J., Ammouche C., Lounis K., Eicher E., Mauvieux L., Desprez D. Post-varicella cerebral thrombophlebitis with anti-protein S: report of a pediatric case. Ann. Biol. Clin. (Paris). 2012;70(1):99-103.Hernandez Blanco A., Gonzalez Montero R., Uran Moreno M. M. et al. Post-varicella purpura fulminans: potentially fatal. An. Pediatr. (Bare). 2009; 70(4):379-382.Hernandez Blanco A., Gonzalez Montero R., Uran Moreno M. M. et al. Post-varicella purpura fulminans: potentially fatal. An. Pediatr. (Bare). 2009; 70(4):379-382.Baur A., Pouyau R., Meunier S., Nougier C., Teyssedre S., Javouhey E. et al. Varicella-associated purpura fulminans and deep vein thrombosis: a pediatric case report. Arch. Pediatr. 2011;18 (7):783-786.Baur A., Pouyau R., Meunier S., Nougier C., Teyssedre S., Javouhey E., Flore D., Gillet Y. Varicella-associated purpura fulminans and deep vein thrombosis: a pediatric case report. Arch. Pediatr. 2011;18 (7):783-786.Matsumoto H., Shimizu T., Tokushige S., Mizuno H., Igeta Y., Hashida H. Rectal Ulcer in a patient with VZV Sacral Meningoradiculitis (Elsberg Syndrome). Intern. Med. 2012;51(6): 651-654.Matsumoto H., Shimizu T., Tokushige S., Mizuno H., Igeta Y., Hashida H. Rectal Ulcer in a patient with VZV Sacral Meningoradiculitis (Elsberg Syndrome). Intern. Med. 2012;51(6): 651-654.Teeninga N., Willemze A. J., Emonts M., Appel I. M. Acute illness following chicken pox: spleen infarction as a complication of varicella zoster infection. Ned. Tijdschr. Geneeskd. 2011; 155(28):A2987.Teeninga N., Willemze A. J., Emonts M., Appel I. M. Acute illness following chicken pox: spleen infarction as a complication of varicella zoster infection. Ned. Tijdschr. Geneeskd. 2011; 155(28):A2987.Lukšić B., Mladinov S., Goić-Barišić I., Srzić A., Brizić I., Perić L. Acute appendicitis, a rare complication of varicella: A report of three cases. J. Infect. 2012; 64 (4):430-433.Lukšić B., Mladinov S., Goić-Barišić I., Srzić A., Brizić I., Perić L. Acute appendicitis, a rare complication of varicella: A report of three cases. J. Infect. 2012; 64 (4):430-433.Vella M., Mastrocinque G., Romeo S., Giammanco G., Melloni D. S1 Herpes zoster localization: acute urinary retention in woman. Urologia. 2011;78(2):145-147.Vella M., Mastrocinque G., Romeo S., Giammanco G., Melloni D. S1 Herpes zoster localization: acute urinary retention in woman. Urologia. 2011;78(2):145-147.Mousali Y. M., Sobhi E. M., Makkawi S. O. Zoster myelitis in sickle cell anemia. Neurosciences (Riyadh). 2011;16(3):273-275.Mousali Y. M., Sobhi E. M., Makkawi S. O. Zoster myelitis in sickle cell anemia. Neurosciences (Riyadh). 2011;16(3):273-275.Bevilacqua S., Poircuitte J. M., Boyer L., May T., Lascombes P., Venard V. Varicella arthritis in childhood: a case report and review of the literature. Pediatr. Infect. Dis. J. 2011;30 (11):980-982.Bevilacqua S., Poircuitte J. M., Boyer L., May T., Lascombes P., Venard V. Varicella arthritis in childhood: a case report and review of the literature. Pediatr. Infect. Dis. J. 2011;30 (11):980-982.Jain M.K., Manjunath K.S., Jagadish S.N. Unusual oral complications of herpes zoster infection: report of a case and re vive of literature. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2010;110(5):37-41.Jain M.K., Manjunath K.S., Jagadish S.N. Unusual oral complications of herpes zoster infection: report of a case and revive of literature. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2010;110(5):37-41.Kang J. H., Sheu J. J., Kao S., Lin H. C. Increased risk of multiple sclerosis following herpes zoster: a nationwide, populationbased study. J. Infect. Dis. 2011;204 (2):188-192.Kang J. H., Sheu J. J., Kao S., Lin H. C. Increased risk of multiple sclerosis following herpes zoster: a nationwide, populationbased study. J. Infect. Dis. 2011;204 (2):188-192.Ordonez G., Martinez-Palomo A., Corona T., Pineda B., Flores-Rivera J., Gonzalez A. et al. Varicella zoster virus in progressive forms of multiple sclerosis. Clin. Neurol. Neurosurg. 2010; 112(8):653-657.Ordonez G., Martinez-Palomo A., Corona T., Pineda B., Flores-Rivera J., Gonzalez A., Chavez-Munguia B., Sotelo J. Varicella zoster virus in progressive forms of multiple sclerosis] Clin. Neurol. Neurosurg. 2010; 112(8):653-657.WHO. The WHO position paper on varicella vaccines. Available from http://www.who.int/vaccines-diseases/diseases/ PP_Varicella. shtml [Accessed March 2006].WHO. The WHO position paper on varicella vaccines. Available from http://www.who.int/vaccines-diseases/diseases/PP_Varicella.shtml [Accessed March 2006Menson E, Heath PT, Lyall H, Ramsay M, Sinka K, Miles J. et al. 2006-2007 chickenpox season: 13 childhood deaths in England, Scotland and Wales compared with averages of 4-8.7 per year in the United Kingdom: more evidence for routine introduction of the varicella vaccine? Arch Dis Child. 2008; 93 (Suppl 1): A75-84.Menson E, Heath PT, Lyall H, Ramsay M, Sinka K, Miles J, Fleming T, Tong W, Breuer J, Nyman AG: 2006–7 chickenpox season: 13 childhood deaths in England, Scotland and Wales compared with averages of 4–8.7 per year in the United Kingdom: more evidence for routine introduction of the varicella vaccine? Arch Dis Child. 2008; 93 (Suppl 1): A75-84.Boёlle P.Y., Hanslik T. Varicella in non-immune persons: incidence, hospitalization and mortality rates. Epidemiol Infect. 2002 Dec;129(3):599-606.Boёlle P.Y., Hanslik T. Varicella in non-immune persons: incidence, hospitalization and mortality rates. Epidemiol Infect. 2002 Dec;129(3):599-606.Grote V., von Kries R., Springer W., Hammersen G., Kreth H.., Liese J. Varicella-related deaths in children and adolescentsGermany 2003-2004. Acta Paediatr. 2008 Feb;97(2):18792. Epub 2007 Dec 10.Grote V., von Kries R. Springer W., Hammersen G., Kreth H.., Liese J. Varicella-related deaths in children and adolescentsGermany 2003-2004. Acta Paediatr. 2008 Feb;97(2):18792. Epub 2007 Dec 10.Rawson H., Crampin A., Noah N. Deaths from chickenpox in England and Wales 1995-1997: analysis of routine mortality data. BMJ. 2001 Nov 10;323(7321):1091-1093Rawson H., Crampin A., Noah N. Deaths from chickenpox in England and Wales 1995-7: analysis of routine mortality data. BMJ. 2001 Nov 10;323(7321):1091-3BMJ. 2001 Nov 10;323(7321):1091-1093.Emery C., Lancon F., Fagnani F., Pechvis M., Durand I., Floret D. ENVOL study on the medical management of varicella and its complications in French ambulatory care. Med Mal Infect. 2006 Feb;36(2):92-98. Epub 2006 Feb 7.Emery C., Lancon F., Fagnani F., Pechvis M., Durand I., Floret D. [ENVOL study on the medical management of varicella and its complications in French ambulatory care. Med Mal Infect. 2006 Feb;36(2):92-98. Epub 2006 Feb 7.Varicella death of an unvaccinated, previously healthy adolescent. Ohio, 2009. MMWR Morb Mortal Wkly Rep. 2013;62:261-263.Varicella death of an unvaccinated, previously healthy adolescent. Ohio, 2009. MMWR Morb Mortal Wkly Rep. 2013;62:261-263.Centers for Disease Control and Prevention. Varicella. In: Atkinson W., Hamborsky J., McIntyre L., Wolfe S, eds. Epidemiology and prevention of vaccine-preventable diseases, 10th edn. Washington DC: Public Health Foundation, 2007:175-196.Centers for Disease Control and Prevention. Varicella. In: Atkinson W., Hamborsky J., McIntyre L., Wolfe S, eds. Epidemiology and prevention of vaccine-preventable diseases, 10th edn. Washington DC: Public Health Foundation, 2007:175-196.Ben Tan, Bettinger J., McConnel A. et al. The Effect of Funded Varicella Immunization Programs on Varicella-related Hospitalizations in IMPACT Centers, Canada, 2000-2008. Ped. Inf. Dis J. 2012; 31(9):956-963.Ben Tan, Bettinger J., McConnel A. et al. The Effect of Funded Varicella Immunization Programs on Varicella-related Hospitalizations in IMPACT Centers, Canada, 2000-2008. Ped. Inf. Dis J. 2012; 31(9):956-963.

The authors declare that there are no conflicts of interest present.