jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2017-9-2-5-12jofin-592Research ArticleОбзорReviewГЕНЕТИЧЕСКОЕ РАЗНООБРАЗИЕ ЦИТОМЕГАЛОВИРУСОВCytomegalovirus genetic diversityВаньковаО. Е.VankovaO. E.

научный сотрудник лаборатории метагеномики и молекулярной индикации патогенов,

Нижний Новгород

Nizhny Novgorod

voe0@mail.ruБруснигинаН. Ф.BrusniginaN. F.

заведующая лабораторией метагеномики и молекулярной индикации патогенов, к.м.н.;

Нижний Новгород

Nizhny Novgorod

Нижегородский научно-исследовательский институт эпидемиологии и микробиологии имени академика И.Н.БлохинойРоссияNizhny Novgorod Science Research Institute of Epidemiology and Microbiology named after Academician I.N. BlokhinaRussian Federation20172006201792512Copyright © Ванькова О.Е., Бруснигина Н.Ф., 20172017Ванькова О.Е., Бруснигина Н.Ф.Vankova O.E., Brusnigina N.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/592

В обзоре представлены современные данные литературы о генетическом разнообразии цитомегаловирусов (ЦМВ), циркулирующих в мире, рассмотрены различные подходы к генотипированию клинических изолятов цитомегаловирусов, дана характеристика основных полиморфных генов, используемых для штаммовой дифференциации, описаны особенности клинического течения цитомегаловирусной инфекции (ЦМВИ) у пациентов групп риска, обусловленной различными генотипами вируса. Информация о спектре циркулирующих цитомегаловирусных генотипов необходима для осуществления эпидемиологического надзора за ЦМВИ и разработки эффективной вакцины.

The review article considers modern data of genetic variety cytomegalovirus , circulating in the world, various approaches to genotyping of cytomegalovirus clinical isolates are represented, the characteristic of basic polymorphic genes, used for strains differentiation is given, the linkage between the strain specific genotypes and the clinical manifestations of cytomegalovirus infection in patients of highrisk groups is described. The information of cytomegalovirus genotypes is necessary for realization cytomegalovirus infection-epidemiological surveillance and development of effective vaccine.

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The authors declare that there are no conflicts of interest present.