References

jofin

Журнал инфектологии

Journal Infectology

2072-6732

IPO “АIDSSPbR"

10.22625/2072-6732-2011-3-4-18-25

jofin-56

Research Article

Обзоры

Review

ПОСЛЕДНИЕ ДОСТИЖЕНИЯ В ЛЕЧЕНИИ ХРОНИЧЕСКОГО ГЕПАТИТА В: С ЧЕГО НАЧИНАТЬ СТАРТОВУЮ ТЕРАПИЮ?

Recent advances in the treatment of chronic hepatitis B: where to start initial therapy?

Жданов

К. В.

Zhdanov

K. V.

начальник кафедры инфекционных болезней Военно-медицинской академии им. С.М. Кирова, д.м.н., профессор, тел. 8 (812)542-92-14

ZhdanovKV@rambler.ru

Военно-медицинская академия имени С.М. Кирова, Санкт-ПетербургРоссияMilitary Medical Academy named after S.M. Kirov, Saint-PetersburgRussian Federation

2011

09092014

341825

2014

Жданов К.В.

Zhdanov K.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.niidi.ru/jofin/article/view/56

В настоящем обзоре обобщены последние достижения в исследовании эффективности и безопасности противовирусной терапии больных хроническим гепатитом В. Описана современная концепция мониторинга и лечения этих пациентов. Особое внимание уделено прогностическому значению определения уровня НВsАgна этапах контроля лечения. Представлены новые алгоритмы интерферонотерапии и подходы к лечению аналогами нуклеоз(т)идов. Предложено начинать стартовую терапию больных хроническим гепатитом В с пегилированных интерферонов.При отсутствии благоприятных прогностических критериев достижения устойчивого иммунного контроля, а также наличия противопоказаний к интерферонотерапии и развитии нежелательных явлений, требующих ее отмены, пациентов необходимо переводить на лечение нуклеоз(т)идными аналогами.

This review summarizes recent advances in the study of the efficacy and safety of antiviral therapy in patients with chronic hepatitis B. Describe the modern concept of monitoring and treatment of these patients. Particular attention is given to determine the prognostic significance of the level of control HBsAg phases of treatment. Present new algorithms of interferon treatment and approaches nukleos(t)ide analogues therapy. Proposed start initial therapy in patients with chronichepatitis B with pegylated interferon. In the absence of favorable prognostic criteria or sustainable immune control, as well as the presence of contraindications tointerferon therapy and the development of adverse events requiring its withdrawal, patients should be translatedinto treatment nukleos(t)ide analogues.

хронический гепатит Винтерферонотерапиянуклеоз(т)идные аналогиНВsАg

chronic hepatitis Binterferonnukleoz(t)ide analoguesHBsAg

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The authors declare that there are no conflicts of interest present.