jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2017-9-1-40-46jofin-559Research ArticleОбзорReviewГЕНЕТИКА ПРЕДРАСПОЛОЖЕННОСТИ К ИНФЕКЦИОННЫМ ЗАБОЛЕВАНИЯМGENETICS OF SUSCEPTIBILITY TO INFECTIOUS DISEASESСуспицынЕ. Н.SuspitsinE. N.

Суспицын Евгений Николаевич – доцент кафедры общей и молекулярной медицинской генетики СПбГПМУ; старший научный сотрудник лаборатории молекулярной онкологии НИИ онкологии им. Н.Н. Петрова, кандидат медицинских наук

Saint-Petersburg

wwave@yandex.ruСкрипченкоЕ. Ю.SkripchenkoE. Yu.

Скрипченко Елена Юрьевна – доцент кафедры психоневрологии СПбГПМУ, старший научный сотрудник отдела нейроинфекций и органической патологии нервной системы Детского научно-клинического центра инфекционных болезней, заведующая детским неврологическим отделением Института мозга человека им. Н.П. Бехтеревой

Saint-Petersburg

wwave@yandex.ruИмянитовЕ. Н.ImyanitovE. N.

Имянитов Евгений Наумович – заведующий кафедрой общей и молекулярной медицинской генетики СПбГПМУ; заведующий отделом биологии опухолевого роста НИИ онкологии им. Н.Н. Петрова. доктор медицинских наук, профессор, член-корреспондент РАН

Saint-Petersburg

evgeny@imyanitov.spb.ruСкрипченкоН. В.SkripchenkoN. V.

Скрипченко Наталья Викторовна – заведующая кафедрой инфекционных заболеваний у детей ФП и ДПО СПбГПМУ, заместитель директора по научной работе Детского научно-клинического центра инфекционных болезней, доктор медицинских наук, профессор, заслуженный деятель науки Российской Федерации

Saint-Petersburg

snv@niidi.ruСанкт-Петербургский государственный педиатрический медицинский университет; Научно-исследовательский институт онкологии им. Н.Н. ПетроваРоссияSaint-Petersburg State Pediatric Medical University; Science Research Institute of Oncology named after N.N.Petrov;Russian FederationСанкт-Петербургский государственный педиатрический медицинский университет; Детский научно-клинический центр инфекционных болезней; Институт мозга человека им. Н.П. БехтеревойРоссияSaint-Petersburg State Pediatric Medical University; Pediatric Research and Clinical Center for Infectious Disease; Institute of Brain named after N.P. BekhterevRussian FederationСанкт-Петербургский государственный педиатрический медицинский университет; Детский научно-клинический центр инфекционных болезнейРоссияSaint-Petersburg State Pediatric Medical University; Pediatric Research and Clinical Center for Infectious DiseaseRussian Federation201705042017914046Copyright © Суспицын Е.Н., Скрипченко Е.Ю., Имянитов Е.Н., Скрипченко Н.В., 20172017Суспицын Е.Н., Скрипченко Е.Ю., Имянитов Е.Н., Скрипченко Н.В.Suspitsin E.N., Skripchenko E.Y., Imyanitov E.N., Skripchenko N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/559

Генетические особенности организма играют важную роль в развитии инфекционных заболеваний, обусловливая восприимчивость к разнообразным бактериям, вирусам и грибам, а также оказывая влияние на течение болезни. Многочисленные исследования свидетельствуют о существовании аллелей предрасположенности к инфекциям. Кроме того, в настоящее время известно около 300 нозологических форм первичных иммунодефицитов (ПИД), которые представляют собой наследственные дефекты иммунитета. Своевременная диагностика таких состояний представляет значительные трудности, однако она крайне необходима для повышения качества лечения пациентов. Использование современных методов ДНК-анализа во многих случаях позволяет установить генетическую причину уязвимости по отношению к тем или иным инфекционным агентам. 

Genetic characteristics of host organism may cause susceptibility to a variety of bacteria, viruses and fungi, as well as influence the course of infectious diseases. Multiple studies indicate the existence of alleles predisposing to infections. Furthermore, there are about 300 nosological entities of primary immunodeficiencies (PID), i.e., inherited defects of immunity. Timely diagnosis of such conditions is quite challenging; however, it is vital for improving quality of patient care. Modern methods of DNA analysis allow establishing genetic causes of vulnerability to certain infectious agents in many individuals

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The authors declare that there are no conflicts of interest present.