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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jofin-486</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case</subject></subj-group></article-categories><title-group><article-title>Случай тяжёлого течения аутохтонного гепатита Е у пожилого мужчины</article-title><trans-title-group xml:lang="en"><trans-title>Heavy flow autochtonic case of hepatitis E in elderly men</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барамзина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Baramzina</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доцент кафедры инфекционных болезней, к.м.н.,</p><p>Киров</p></bio><bio xml:lang="en"><p>Kirov</p></bio><email xlink:type="simple">sw3837@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Любезнова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyubeznova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доцент кафедры инфекционных болезней, к.м.н.,</p><p>Киров</p></bio><bio xml:lang="en"><p>Kirov</p></bio><email xlink:type="simple">lyubolga@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Протасов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Protasov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-инфекционист,</p><p>Киров</p></bio><bio xml:lang="en"><p>Kirov</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Утенкова</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Utenkova</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор кафедры инфекционных болезней, д.м.н.,</p><p> Киров</p></bio><bio xml:lang="en"><p>Kirov</p></bio><email xlink:type="simple">utelol@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осокина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Osokina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>главный врач,</p><p>Киров</p></bio><bio xml:lang="en"><p>Kirov</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кировская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kirov State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кировская инфекционная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kirov Infectious Diseases Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>07</month><year>2016</year></pub-date><volume>8</volume><issue>2</issue><fpage>97</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Барамзина С.В., Любезнова О.Н., Протасов А.В., Утенкова Е.О., Осокина А.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Барамзина С.В., Любезнова О.Н., Протасов А.В., Утенкова Е.О., Осокина А.А.</copyright-holder><copyright-holder xml:lang="en">Baramzina S.V., Lyubeznova O.N., Protasov A.V., Utenkova E.O., Osokina A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/486">https://journal.niidi.ru/jofin/article/view/486</self-uri><abstract><p>В статье представлен анализ первого клинического случая аутохтонного острого гепатита Е на территории Кировской области. HEV-инфекция была диагностирована у 76-летнего мужчины, не выезжавшего за пределы области и страны в течение длительного времени, употреблявшего много свежих фруктов. Особенностью заболевания в неэндемичном регионе явилось: тяжёлое течение гепатита Е в пожилом возрасте, с развитием клиники острой печёночной недостаточности и энцефалопатии, наличие выраженного синдрома цитолиза, холестаза, печёночно-клеточной недостаточности.</p><p>Своевременное обращение больного за медицинской помощью, отсутствие тяжёлых соматических заболеваний, хронической патологии печени и адекватная патогенетическая терапия позволили сохранить жизнь больного. При расшифровке недифференцированных острых гепатитов у пожилых необходимо включать в схему обследования определение HEVRNA и а/HEV IgM и G.</p></abstract><trans-abstract xml:lang="en"><p>The article presents an analysis of the first clinical cases of acute hepatitis E autochtonic on the territory of the Kirov region. HEV-infection was diagnosed in 76 year old male, not to travel outside the region and the country for a long time, eat a lot of fresh fruit. A feature of the disease in non-endemic region was: severe course of hepatitis E in the elderly, with the development of clinic of acute liver failure and encephalopathy, the presence of the expressed syndrome cytolysis, cholestasis, hepatic-cell failure.</p><p>Timely treatment of a patient for medical care, the lack of severe somatic diseases, chronic liver disease and adequate pathogenetic therapy helped to keep the patient’s life. In deciphering undifferentiated acute hepatitis in the elderly should be included in the scheme of examination and determination HEV RNA, a/HEV IgM and G.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый аутохтонный гепатит Е у пожилых</kwd><kwd>острая печёночная энцефалопатия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute autochthonous hepatitis E in the elderly</kwd><kwd>acute hepatic encephalopathy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гепатит Е // Информационный бюллетень. – 2015. – № 280. –http: //www. Who. Int /mediacentre /factsheets/fs280/ru/. – Дата доступа: 27.04.16</mixed-citation><mixed-citation xml:lang="en">Gepatit E.//Informacionnyj bjulleten’; 2015, N280. http: //www. Who. 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