jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2015-7-4-10-22jofin-438Research ArticleОбзорыReviewИНТЕРФЕРОН-γ: БИОЛОГИЧЕСКАЯ ФУНКЦИЯ И ЗНАЧЕНИЕ ДЛЯ ДИАГНОСТИКИ КЛЕТОЧНОГО ИММУННОГО ОТВЕТАInterferon-γ: biological function and application for study of cellular immune responseЛуцкийА. А.LutckiiA. A.

научный сотрудник отдела вирусных гепатитов и заболеваний печени Научно-исследовательского института детских инфекций, к.м.н.; тел.: 8(812)234-34-16

a.lutskij@niidi.ruЖирковА. А.ZhirkovA. A.

младший научный сотрудник отдела клинической лабораторной диагностики Научно-исследовательского института детских инфекций; тел.: 8(812)234-34-18

ant-zhirkov@yandex.ruЛобзинД. Ю.LobzinD. Yu.

врач-инфекционист клиники инфекционных болезней Военно-медицинской академии им С.М. Кирова; тел.: +7-999-200-24-45

dlobzin89@mail.ruРаоМ.RaoM.

PhD, исследователь-постдокторант отдела терапевтической иммунологии (TIM) департамента лабораторной медицины (LABMED) Каролинского университета; тел.: +46-7-621-84-653

martin.rao@ki.seАлексееваЛ. А.AlekseevaL. A.

руководитель отдела клинической лабораторной диагностики Научно-исследовательского института детских инфекций, д.м.н.; тел.: 8(812)234-34-18

kldidi@mail.ruМейрерМ.MaeurerM.

MD, PhD, FRCP (Лондон), профессор отдела терапевтической иммунологии (TIM) департамента лабораторной медицины (LABMED) и департамента микробиологии, опухолевой и клеточной биологии Каролинского университета, Центра трансплантации аллогенных стволовых клеток (CAST) Каролинского университетского госпиталя; тел.: +46-8-585-816-23

markus.maeurer@ki.seЛобзинЮ. В.LobzinYu. V.

директор Научно-исследовательского института детских инфекций, академик РАН, д.м.н., профессор; тел.: 8(812)234-60-04

niidi@niidi.ruНаучно-исследовательский институт детских инфекций, Санкт-Петербург, РоссияРоссияScience Research Institute of Children’s Infection, Saint-Petersburg, RussiaRussian FederationВоенно-медицинская академия имени С.М. Кирова, Санкт-Петербург, РоссияРоссияMilitary Medical Academy named after S.M. Kirov, Saint-Petersburg, RussiaRussian FederationОтдел терапевтической иммунологии, Департамент лабораторной медицины, Каролинский университет, Стокгольм, ШвецияРоссияDivision of Therapeutic Immunology (TIM), LABMED, Karolinska Institutet, Stockholm, SwedenRussian FederationОтдел терапевтической иммунологии, Департамент лабораторной медицины, Каролинский университет, Стокгольм, Швеция Департамент микробиологии, опухолевой и клеточной биологии, Каролинский университет, Стокгольм, Швеция Центр трансплантации аллогенных стволовых клеток, Каролинский университетский госпиталь, Стокгольм, ШвецияРоссияDivision of Therapeutic Immunology (TIM), LABMED, Karolinska Institutet, Stockholm, Sweden Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden CAST, Karolinska University Hospital, Stockholm, SwedenRussian Federation201515022016741022Copyright © Луцкий А.А., Жирков А.А., Лобзин Д.Ю., Рао М., Алексеева Л.А., Мейрер М., Лобзин Ю.В., 20162016Луцкий А.А., Жирков А.А., Лобзин Д.Ю., Рао М., Алексеева Л.А., Мейрер М., Лобзин Ю.В.Lutckii A.A., Zhirkov A.A., Lobzin D.Y., Rao M., Alekseeva L.A., Maeurer M., Lobzin Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/438

Клеточный иммунный ответ играет важную роль в борьбе с внутриклеточными патогенами, такими как вирусы, некоторые бактерии и паразиты. Оценить наличие, специфичность и напряженность клеточного ответа можно путем исследования реакции клеток иммунной системы на специфические раздражители, такие как антиген. К основным реакциям на антиген-стимуляцию относятся продукция цитокинов, пролиферация и цитотоксичность. В данном обзоре рассмотрен интерферон-гамма как один из центральных Тх1 цитокинов: его биология, иммунологическая роль и использование в качестве маркера клеточного иммунного ответа.

Cellular immune response plays a central role in control of intracellular pathogens like viruses, some bacteria and parasites. Evaluation of presence, specificity and strength of cellular immune response can be done by investigation of reaction of immune cells to specific stimulus, like antigen. The major cellular reactions to antigen stimulation are production of cytokines, proliferation and cytotoxicity. This review is focused on interferon-gamma as one of the central Th1 cytokines: its biology, immunological role and application as marker of cellular immune response.

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The authors declare that there are no conflicts of interest present.