jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2015-7-2-83-91jofin-402Research ArticleОригинальные исследованияOriginal ResearchДинамика уровня интерлейкина-6 у ВИЧ-инфицированных больных с опоясывающим герпесомThe dynamics of interleukin-6level in HIV-infected patients with herpes zosterЯкубенкоА. Л.YakubenkoA. L.

аспирант кафедры инфекционных болезней, эпидемиологии и дерматовенерологии медицинского факультета Санкт-Петербургского государственного университета; тел.: 8(812)717-18-40

sasha.yakubenko@gmail.comЯковлевА. А.YakovlevA. A.

заведующий кафедрой инфекционных болезней, эпидемиологии и дерматовенерологии медицинского факультета Санкт-Петербургского государственного университета, главный врач Клинической инфекционной больницы им. С.П. Боткина, д.м.н., профессор; тел.: (812) 717-28-48

botkin_hosp@zdrav.spb.ruМусатовВ. Б.MusatovV. B.

доцент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии медицинского факультета Санкт-Петербургского государственного университета, заместитель главного врача по медицинской части Клинической инфекционной больницы им. С.П. Боткина, к.м.н.; тел.: 8(812)717-77-61 

botkin_hosp@zdrav.spb.ruКингоЗ. Н.KingoZ. N.

врач лабораторной диагностики Клинической инфекционной больницы им. С.П. Боткина, к.м.н.; тел.: 8(812)717-78-0

kingospb@mail.ruГорбоваИ. В.GorbovaI. V.

заведующая клинико-диагностической экспресс-лабораторией Клинической инфекционной больницы им. С.П. Боткина; тел.: 8(812)717-78-02

valinnag@mail.ruАндрееваИ. Л.AndreevaI. L.

врач лабораторной диагностики Клинической инфекционной больницы им. С.П. Боткина; тел.: 8(812)717-78-02

lisavet@list.ruКомароваА. Я.KomarovaA. Ya.

ассистент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии медицинского факультета Санкт-Петербургского государственного университета, к.м.н.; тел.: 8(812)717-26-44

alexandra-yanovna@yandex.ruСанкт-Петербургский государственный университет, Санкт-Петербург, РоссияРоссияSaint Petersburg State University, Saint-Petersburg, RussiRussian FederationСанкт-Петербургский государственный университет, Санкт-Петербург, Россия Клиническая инфекционная больница им. С.П. Боткина, Санкт-Петербург, РоссияРоссияSaint Petersburg State University, Saint-Petersburg, Russi Clinical Infectious Diseases Hospital named after S.P. Botkin, Saint-Petersburg, RussiaRussian FederationКлиническая инфекционная больница им. С.П. Боткина, Санкт-Петербург, РоссияРоссияClinical Infectious Diseases Hospital named after S.P. Botkin, Saint-Petersburg, RussiaRussian Federation201507072015728391Copyright © Якубенко А.Л., Яковлев А.А., Мусатов В.Б., Кинго З.Н., Горбова И.В., Андреева И.Л., Комарова А.Я., 20152015Якубенко А.Л., Яковлев А.А., Мусатов В.Б., Кинго З.Н., Горбова И.В., Андреева И.Л., Комарова А.Я.Yakubenko A.L., Yakovlev A.A., Musatov V.B., Kingo Z.N., Gorbova I.V., Andreeva I.L., Komarova A.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/402

Интерлейкин-6 играет центральную роль в противовирусном иммунитете. Однако функция данного цитокина в патогенезе опоясывающего герпеса не изучена. 

Целью исследования было определить динамику уровня интерлейкина-6 в сыворотке крови у ВИЧ-инфицированных больных с опоясывающим герпесом. 

В исследование были включены 55 пациентов с опоясывающим герпесом (30 ВИЧ-позитивных и 25 ВИЧнегативных). Анализировался уровень сывороточного интерлейкина-6 до начала лечения ацикловиром, на 3-й день лечения и после заживления высыпаний. Также оценивались клиническое течение и динамика лабораторных показателей. 

Было выявлено, что повышенный уровень сывороточного интерлейкина-6 достоверно ассоциирован с положительным ВИЧ-статусом, выраженностью высыпаний, повышением температуры тела и снижением количества CD4-лимфоцитов. В процессе лечения опоясывающего герпеса уровень интерлейкина-6 у ВИЧинфицированных пациентов значимо снижался, достигая значений ВИЧ-негативной группы. Также было установлено, что при осложнённом течении опоясывающего герпеса у больных с ВИЧ-инфекцией и низким уровнем CD4-лимфоцитов (менее 350 кл/мкл) концентрация интерлейкина-6 значимо превышала таковую в случае неосложнённого течения заболевания. 

Interleukin-6 plays a central role in antiviral immunity. However, the function of this cytokine in the pathogenesis of herpes zoster is unknown. 

The objective of this study was todeterminethe dynamicsof serum interleukin-6 level in HIV-infected patients with herpes zoster. 

55 patients with herpes zoster (30 HIV-positive and 25 HIV-negative) were included. Serum interleukin-6 levels were measured before acyclovir treatment, on the 3rd day of treatment and after healing of skin lesions. The clinical course and dynamics of laboratory data were also evaluated. 

The study showed that elevated serum levels of interleukin-6 were associated with HIV-positive status, severity of rash, fever anddecreaseof CD4-lymphocytes. Levels of interleukin-6 in HIV-infected patients were significantly reduced during herpes zoster treatment and reached the level of HIVnegative cohort.Interleukin-6 levels in complicated course of herpes zoster in HIV-infected patients with low CD4-lymphocyte count (less than 350 cells/ml) were significantly higher compared to levels in uncomplicated course of the disease. 

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The authors declare that there are no conflicts of interest present.