jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2010-2-3-4-15jofin-309Research ArticleОбзорыReviewБАКТЕРИАЛЬНЫЕ БИОПЛЕНКИ И ИНФЕКЦИИBacterial biofilms and infectionsГостевВ. В.GostevV. V.

младший научный сотрудник отдела молекулярной микробиологии и эпидемиологии ФГУ «Научно-исследовательского института детских инфекций Федерального медико-биологического агентства России» тел.: 8-905-220-97-41

СидоренкоС. В.SidorenkoS. V.

доктор медицинских наук, профессор, руководитель отдела молекулярной микробиологии и эпидемиологии ФГУ «Научно-исследовательского института детских инфекций Федерального медико-биологического агентства России», тел.: 8(963)316-08-08

sidorserg@gmail.comНаучно-исследовательский институт детских инфекций ФМБА России, Санкт-ПетербургРоссияResearch Institute of Children Infections of FMBA of Russia, Saint-PetersburgRussian Federation20102509201423415Copyright © Гостев В.В., Сидоренко С.В., 20142014Гостев В.В., Сидоренко С.В.Gostev V.V., Sidorenko S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/309

В настоящее время общепризнано, что основной формой существования бактерий в естественных условиях являются связанные с поверхностью сообщества, получившие название биопленок, а не отдельные планктонные клетки. Биопленки обнаруживают более чем в 80% хронических инфекционных и воспалительных заболеваний, что позволило выдвинуть концепцию хронических болезней как болезней биопленок. Для обмена информацией в пределах биопленки между отдельными клетками одного и того же или разных видов бактерии используют секретируемые феромоны, например сигнальные молекулы системы quorum sensing. Координация различных видов активности бактериальных клеток в составе биопленок обеспечивает им значительные преимущества. В составе биопленок бактерии оказываются защищенными от действия факторов резистентности хозяина и антибактериальных препаратов. Одним из возможных механизмов повышения устойчивости бактерий к внешним воздействиям и антибактериальным препаратам является значительное увеличение в составе биопленок доли клеток-персистеров.

It is now a common perception that the vast majority of bacterial life in nature is found in surface-bound communities called biofilms rather than in isolated planktonic cells. Biofilms are implicated in more than 80% of chronic inflammatory and infectious diseases. The biofilm model allows the reconceptualization of multiple chronic diseases as biofilm diseases. The biofilm bacterial community uses secreted pheromones (eg, quorum sensing molecules) and other molecules for cell-cell signaling, even between species. These coordinated activities during formation of biofilms render the bacterial community numerous benefits. Biofilms confer resistance to many antimicrobials, and protection against host defenses. One possible reason for the increased resistance to environmental stresses and antibacterials observed in biofilm cells appears to be the increase in the portion of persister cells within the biofilm.

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The authors declare that there are no conflicts of interest present.