jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2026-18-2-107-115jofin-1995Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHАнализ некоторых вариантов гена TRIM5 У ВИЧ-инфицированных лицAnalysis of some TRIM5 gene variants in HIV-infected patientsОстанковаЮ. В.OstankovaYu. V.

Останкова Юлия Владимировна – заведующий лабораторией иммунологии и вирусологии ВИЧ-инфекции, старший научный сотрудник лаборатории молекулярной иммунологии, к.б.н.

Санкт-Петербург

Saint-Petersburg

shenna1@yandex.ruДавыденкоВ. С.DavydenkoV. S.

Давыденко Владимир Сергеевич – младший научный сотрудник лаборатории иммунологии и вирусологии ВИЧ-инфекции.

Санкт-Петербург

Saint-Petersburg

vladimir_david@mail.ruЩемелевА. Н.SchemelevA. N.

Щемелев Александр Николаевич – младший научный сотрудник лаборатории иммунологии и вирусологии ВИЧ-инфекции, к.б.н.

Санкт-Петербург

Saint-Petersburg

tvildorm@gmail.comТотолянА. А.TotolianA. A.

Тотолян Арег Артемович – заведующий лабораторией молекулярной иммунологии, директор, д.м.н., профессор, академик РАН.

Санкт-Петербург, тел.: 8(812)232-00-66

Saint-Petersburg

totolian@pasteurorg.ruСанкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. ПастераРоссияSaint-Petersburg Science Research Institute namfe after PasteurRussian Federation202620062026182107115Copyright © Останкова Ю.В., Давыденко В.С., Щемелев А.Н., Тотолян А.А., 20262026Останкова Ю.В., Давыденко В.С., Щемелев А.Н., Тотолян А.А.Ostankova Y.V., Davydenko V.S., Schemelev A.N., Totolian A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1995Цель

Цель: анализ некоторых вариантов гена TRIM5 у ВИЧ-инфицированных лиц.

Материалы и методы

Материалы и методы: проведен анализ вариантов rs10838525 (R136Q) и rs3740996 (H43Y) гена TRIM5 в группах ВИЧ-инфицированных лиц с вирусологической неэффективностью          антиретровирусной       терапии (n = 378) и контрольная группа (n = 319) (лица без острых или хронических инфекционных и соматических заболеваний на момент обследования) из Северо-Западного региона России. Генотипирование выполнено методом полимеразной цепной реакции с последующим секвенированием. Статистический анализ включал проверку равновесия Харди – Вайнберга, оценку ассоциаций по 3 моделям наследования (доминантной, рецессивной, аддитивной) с расчетом отношения шансов (OR) и 95% доверительного интервала, а также анализ гаплотипов.

Результаты

Результаты: выявлены достоверные различия в распределении генотипов между группами указанных вариантов (p < 0,0001). Аллель 136R (rs10838525) ассоциирован с повышенным риском ВИЧ-инфекции (ORаддитив. = 1,67; 95% ДИ 1,33–2,10), тогда как аллель 43Y (rs3740996) показал протективный эффект (ORаддитив. = 0,55; 95% ДИ 0,44–0,70; p < 0,0001). Анализ гаплотипов подтвердил разнонаправленность эффектов: гаплотип R–H ассоциирован с повышенным риском (OR = 1,55; p = 0,0047), а гаплотип Q–Y – с пониженным (OR = 0,49; p < 0,0001).

Заключение

Заключение: для российской популяции варианты гена TRIM5 R136Q и H43Y являются значимыми генетическими факторами ассоциации с ВИЧ-инфекцией, оказывая противоположные эффекты. Полученные данные подчеркивают важность учета популяционной специфики и необходимости дальнейшего изучения роли белков семейства TRIM в патогенезе ВИЧ-инфекции с учетом региональных особенностей.

The aim of this study was to analyze of some TRIM5 gene variants in HIV-infected individuals

Materials and methods

Materials and methods. The analysis of the rs10838525 (R136Q) and rs3740996 (H43Y) variants of the TRIM5 gene was performed in groups of HIV-infected individuals with virological failure of antiretroviral therapy (n = 378) and control group (n = 319) (individuals without acute or chronic infectious and somatic diseases at the time of examination) from the Northwestern region of Russia. Genotyping was carried out by PCR followed by sequencing. Statistical analysis included testing for Hardy-Weinberg equilibrium, assessment of associations under three inheritance models (dominant, recessive, additive) with calculation of odds ratios (OR) and 95% confidence intervals (CI), as well as haplotype analysis.

Results

Results. Statistically significant differences in the distribution of genotypes between the groups were identified for the specified variants (p < 0.0001). The 136R allele (rs10838525) was associated with an increased risk of HIV infection (additive OR = 1.67; 95% CI 1.33–2.10), whereas the 43Y allele (rs3740996) demonstrated a protective effect (additive OR = 0.55; 95% CI 0.44–0.70; p < 0.0001). Haplotype analysis confirmed the divergence of effects: the R-H haplotype was associated with an increased risk (OR = 1.55; p = 0.0047), while the Q-Y haplotype was associated with a reduced risk (OR = 0.49; p < 0.0001).

Conclusion

Conclusion. This study establishes that the R136Q and H43Y variants of the TRIM5 gene are significant genetic factors associated with HIV infection in the Russian population, exerting opposing effects on susceptibility. These findings underscore the importance of accounting for population-specific genetic architecture and highlight the need for further investigation into the role of TRIM family proteins in HIV pathogenesis, with careful consideration of regional variations.

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The authors declare that there are no conflicts of interest present.