jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2026-18-2-71-79jofin-1990Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHНосительство метициллин-резистентного золотистого стафилококка в носовой полости в больницах третьего уровня: доказательства внутрибольничной передачи инфекции в НигерииNasal methicillin-resistant staphylococcus aureus carriage in tertiary hospitals: Evidence of hospitalacquired transmission in NigeriaOkoroC. J.OkoroC. J.

Enugu, Enugu State

Senior Lecturer, Department of Medical Laboratory Science.

Enugu, Enugu State

DavidЕ. E.DavidE. E.

Abakaliki

Faculty member at the Department of biochemistry of Alex Ekwueme Federal University.

Abakaliki

IrohaС. S.IrohaC. S.

Abakaliki

Senior Pharmacist, Pharmacy Unit of Alex Ekwueme Federal University.

Abakaliki

EjikeugwuС.EjikeugwuC.

Enugu, Enugu State

Senior Lecturer Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Science.

Enugu, Enugu State

DoweЕ.DoweE.

Abraka, Delta State

Abraka, Delta State

NwabuezeЕ. F.NwabuezeE. F.

Galveston, TX

Senior Data Analyst, Department of Biostatistics and Data Science, School of Public and Population Health.

Galveston, TX

IrohaI. R.IrohaI. R.

Abakaliki, Ebonyi State

Professor of pharmaceutical microbiology, Department of Applied Microbiology, Faculty of Science.

Abakaliki, Ebonyi State

Renaissance University UgbawkaНигерияRenaissance University UgbawkaNigeriaAlex Ekwueme Federal UniversityНигерияAlex Ekwueme Federal UniversityNigeriaEnugu State University of Science and TechnologyНигерияEnugu State University of Science and TechnologyNigeriaDelta State UniversityНигерияDelta State UniversityNigeriaUniversity of Texas Medical BranchСоединённые Штаты АмерикиUniversity of Texas Medical BranchUnited StatesEbonyi State UniversityНигерияEbonyi State UniversityNigeria2026200620261827179Copyright © Okoro C.J., David Е.E., Iroha С.S., Ejikeugwu С., Dowe Е., Nwabueze Е.F., Iroha I.R., 20262026Okoro C.J., David Е.E., Iroha С.S., Ejikeugwu С., Dowe Е., Nwabueze Е.F., Iroha I.R.Okoro C.J., David E.E., Iroha C.S., Ejikeugwu C., Dowe E., Nwabueze E.F., Iroha I.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1990

Носительство метициллин-резистентного золотистого стафилококка (MRSA) в носовой полости является значительным источником инфекции и передачи инфекции в больничных условиях. Эффективный инфекционный контроль и рациональное использование антибиотиков затруднены в странах с низким и средним уровнем дохода из-за отсутствия данных местного мониторинга. В этом исследовании изучались распространенность, характер антимикробной резистентности и генетические детерминанты MRSA у пациентов и медицинских работников в 2 больницах третьего уровня в Нигерии. Всего было собрано 1309 образцов мазков из носовой полости у стационарных пациентов, медицинских работников и амбулаторных пациентов из 2 разных больниц третьего уровня. Золотистый стафилококк был идентифицирован и выделен с использованием стандартных биохимических методов. MRSA были фенотипически обнаружены с использованием хромагара Brilliance MRSA и цефокситина, после чего проводилось тестирование на чувствительность к антимикробным препаратам по стандартному методу дисковой диффузии Кирби – Бауэра. Для скрининга генов mecA и pvl в 10 случайно выбранных образцах MRSA использовались ПЦР-специфические праймеры. Из 1309 собранных образцов из носовой полости было выделено 575 штаммов S. aureus, что составляет 43,9%, из которых 96 (17%) были MRSA, 81 – от стационарных/амбулаторных пациентов и 15 – от медицинских работников. Наибольшее количество MRSA было обнаружено у стационарных пациентов и врачей – 73/81 и 8/15 соответственно. Все изоляты MRSA, устойчивые к цефокситину, также оказались устойчивыми к тетрациклину, амоксициллину и амоксициллину-клавулановой кислоте. Гены mecA и pvl были обнаружены в 5 изолятах. Однако ген pvl был обнаружен в 1 изоляте без соответствующего обнаружения гена mecA. Высокая частота носительства MRSA среди пациентов и медицинского персонала подчеркивает потенциал внутрибольничной передачи инфекции и необходимость усиления инфекционного контроля и рационального использования антибиотиков в нигерийских больницах третьего уровня.

Methicillin-resistant staphylococcus aureus (MRSA) nasal carriage is a significant source of infection and transmission in hospital environments. Effective infection control and antimicrobial stewardship are hampered in low-and middleincome countries by a lack of local monitoring data. This study investigated the prevalence, antimicrobial resistance pattern and genetic determinants of MRSA in patients and healthcare in two tertiary hospitals in Nigerian. A total 1, 309 nasal swabs specimens were collected from in-patients, healthcare workers and out-patients from two different tertiary hospitals. Staphylococcus aureus was identified and isolated using standard biochemical methods. The MRSA were phenotypically detected using Brilliance MRSA chromagar and cefoxitin and latter subjected to antimicrobial susceptibility testing following the standard Kirby–Bauer disk diffusion method. PCR-specific primers were used to screen for mecA and pvl genes in ten randomly selected MRSA. Out of the 1,309 nasal samples collected, 575 S. aureus representing 43.9% were isolated from the nasal samples of which 96 (17%) were MRSA, 81 from in-patients/out-patients and 15 from health care workers. The in-patients and doctors habour the highest number of MRSA, 73/81 and 8/15 respectively. All the MRSA isolates resistant to cefoxitin were also found to be resistant to tetracycline, amoxicillin, and amoxicillin-clavulanic acid. The mecA and pvl genes were detected in five of the isolates. However, pvl gene was detected in one isolate without corresponding detection of mecA gene. The high frequency of MRSA carriage among patients and healthcare personnel underscores the potential for hospital-acquired transmission and highlights the need for strengthened infection control and antibiotic stewardship in Nigerian tertiary hospitals.

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The authors declare that there are no conflicts of interest present.