jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2013-5-4-5-13jofin-194Research ArticleОбзорыReviewТЕРАПИЯ ОСТРЫХ КИШЕЧНЫХ ИНФЕКЦИЙ У ДЕТЕЙ. ДОКАЗАННАЯ ЭФФЕКТИВНОСТЬ (ОБЗОР ЛИТЕРАТУРЫ)Therapy of Acute Intestinal Infections in Children: Proven EfficiencyХалиуллинаС. В.KhaliullinaS. V.

докторант кафедры детских инфекций Казанского государственного медицинского университета, к.м.н.; тел.: +7-917-860-92-46

svekhal@mail.ruАнохинВ. А.AnokhinV. A.

заведующий кафедрой детских инфекций Казанского государственного медицинского университета, д.м.н., профессор; тел.: 8(843)267-81-00, +7-903-306-33-70

anokhin56@mail.ruКазанский государственный медицинский университет, КазаньРоссияKazan State Medicine University, KazanRussian Federation20131609201454513Copyright © Халиуллина С.В., Анохин В.А., 20142014Халиуллина С.В., Анохин В.А.Khaliullina S.V., Anokhin V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/194

В статье рассмотрены вопросы этиотропной, патогенетической и симптоматической терапии острых инфекционных диарей у детей. Рекомендации приведены с учетом основных принципов доказательной медицины, включающие суммарные данные рандомизированных клинических испытаний, мета-анализов. Обсуждены новые направления в лечении – возможность применения противорвотных, антидиарейных, антисекреторных, пробиотических препаратов в педиатрической практике.

The paper focuses on questions of etiotropic, pa diarrhea in children. The recommendations are given with the basic principles of evidence-based medicine including summary data from randomized clinical trials and metaanalyses. The new lines of the treatment are discussed suchas the possibility of application of antiemetic, antidiarrheal, antisecretory, probiotic drugs in pediatric practice.

острые инфекционные диареилечениедетиacute infectious diarrheatreatmentchildrenReferencesGuerrant, R.L. Practice guidelines for the management of infectious diarrhea / R.L.Guerrant [et al.] // Clin Infect Dis. – 2001. – V. 32, № 3. – P. 331–351.Guerrant, R.L. Practice guidelines for the management of infectious diarrhea / R.L.Guerrant [et al.] // Clin Infect Dis. – 2001. – V. 32, № 3. – P. 331–351.Bresee, J.S. The etiology of severe acute gastroenteritis among adults visiting emergency departments in the United States / J.S. Bresee [et al.] // J Infect Dis. – 2012. – V. 205, № 1. – P. 1374–1381.Bresee, J.S. The etiology of severe acute gastroenteritis among adults visiting emergency departments in the United States / J.S. Bresee [et al.] // J Infect Dis. – 2012. – V. 205, № 1. – P. 1374–1381.King, C.К. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy /C.K. King [et al.] // MMWR Recomm Rep. – 2003. – V. 52, № 16 – P. 1–16.King, C.К. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy /C.K. King [et al.] // MMWR Recomm Rep. – 2003. – V. 52, № 16 – P. 1–16.Guarino, A. European Society for Paediatric Gastroenterology, Hepatology аnd Nutrition / European Society for PaediatricInfectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe /А.Guarino [et al.] // J Pediatr Gastroenterol Nutr. – 2008. – V. 46, № 5. – P. 619–621.Guarino, A. European Society for Paediatric Gastroenterology, Hepatology аnd Nutrition / European Society for PaediatricInfectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe /А.Guarino [et al.] // J Pediatr Gastroenterol Nutr. – 2008. – V. 46, № 5. – P. 619–621.Caprioli, A. Enteropathogens associated with childhood diarrhea in Italy. The Italian Study Group on Gastrointestinal Infections / A. Caprioli [et al.] // Pediatr Infect Dis J. – 1996. – V. 15, № 10. – P. 876–883.Caprioli, A. Enteropathogens associated with childhood diarrhea in Italy. The Italian Study Group on Gastrointestinal Infections / A. Caprioli [et al.] // Pediatr Infect Dis J. – 1996. – V. 15, № 10. – P. 876–883.De Wit, M.А. Etiology of gastroenteritis in sentinel general practices in the Netherlands / М.А. De Wit [et al.] // Clin Infect Dis. – 2001. – V. 7, № 1. – P. 82–91.De Wit, M.А. Etiology of gastroenteritis in sentinel general practices in the Netherlands / М.А. De Wit [et al.] // Clin Infect Dis. – 2001. – V. 7, № 1. – P. 82–91.Guandalini, S. Lactobacillus GG administered in oral ehydration solution to children with acute diarrhea: a multicenter European trial / S. Guandalini [et al.] // J Pediatr Gastroenterol Nutr . – 2000. – V. 30, № 1. – P. 54–60.Guandalini, S. Lactobacillus GG administered in oral ehydration solution to children with acute diarrhea: a multicenter European trial / S. Guandalini [et al.] // J Pediatr Gastroenterol Nutr . – 2000. – V. 30, № 1. – P. 54–60.Maltezou, H.С. Acute diarrhoea in children treated in an outpatient setting in Athens, Greece / Н.С. Maltezou [et al.] //J Infect. – 2001. – V. 43, № 2. – P. 122–127.Maltezou, H.С. Acute diarrhoea in children treated in an outpatient setting in Athens, Greece / Н.С. Maltezou [et al.] //J Infect. – 2001. – V. 43, № 2. – P. 122–127.Olesen, B. Etiology of diarrhea in young children in Denmark: a case-control study / B.Olesen [et al.] // J Clin Microbiol. – 2005. – V. 43, № 8. – P. 3636–3641.Olesen, B. Etiology of diarrhea in young children in Denmark: a case-control study / B.Olesen [et al.] // J Clin Microbiol. – 2005. – V. 43, № 8. – P. 3636–3641.Tompkins, D.S. A study of infectious intestinal disease in England: microbiological findings in cases and controls /D.S.Tompkins [et al.] // Commun Dis Public Health. – 1999. – № 2. – P. 108–113.Tompkins, D.S. A study of infectious intestinal disease in England: microbiological findings in cases and controls /D.S.Tompkins [et al.] // Commun Dis Public Health. – 1999. – № 2. – P. 108–113.Годовой отчет референс-центра по мониторингу возбудителей острых кишечных инфекций (РЦКИ) за 2012 год // http://www.epid-oki.ru/cont/analit_pism/Godovoj_ otchet_referens-entra_po_monitoringu_vozbuditelej_ostryh_kishechnyh_infekcij.pdfГодовой отчет референс-центра по мониторингу возбудителей острых кишечных инфекций (РЦКИ) за 2012 год // http://www.epid-oki.ru/cont/analit_pism/Godovoj_ otchet_referens-entra_po_monitoringu_vozbuditelej_ostryh_kishechnyh_infekcij.pdfОфициальный сайт роспотребнадзора РТ. – //http://16.rospotrebnadzor.ru/Официальный сайт роспотребнадзора РТ. – //http://16.rospotrebnadzor.ru/Acute diarrhea in adults and children: a global perspective. WGO, February 2012 // http://www.worldgastroenterology. org/assets/export/userfiles/Acute%20Diarrhea_long_FINAL_120604.pdfAcute diarrhea in adults and children: a global perspective. WGO, February 2012 // http://www.worldgastroenterology. org/assets/export/userfiles/Acute%20Diarrhea_long_FINAL_120604.pdfЛечение диареи. Учебное пособие для врачей и других категорий медработников старшего звена. ВОЗ, 2006. –http://www.euro.who.int/__data/assets/pdf_file/0007/130696/9244593181R.pdfЛечение диареи. Учебное пособие для врачей и других категорий медработников старшего звена. ВОЗ, 2006. –http://www.euro.who.int/__data/assets/pdf_file/0007/130696/9244593181R.pdfWorld Gastroenterology Organisation (WGO). WGO practice guideline: acute diarrhea. Munich, Germany: World Gastroenterology Organisation (WGO); 2008 Mar. 28 p. – http://www.guideline.gov/content.aspx?id=12679&search= salmonellosisWorld Gastroenterology Organisation (WGO). WGO practice guideline: acute diarrhea. Munich, Germany: World Gastroenterology Organisation (WGO); 2008 Mar. 28 p. – http://www.guideline.gov/content.aspx?id=12679&search= salmonellosisEditorial. Oral therapy for acute diarrhea / No authors listed // Lancet. – 1981. – V. 8247, № 2. – P. 615–617.Editorial. Oral therapy for acute diarrhea / No authors listed // Lancet. – 1981. – V. 8247, № 2. – P. 615–617.Onwuezobe, I.A. Antimicrobials for treating symptomatic non-typhoidal Salmonella infection / I.A.Onwuezobe, Р.О.Oshun, С.С.Odigwe // Cochrane Database Syst Rev. – 2012. – № 11. – P. 1167.Onwuezobe, I.A. Antimicrobials for treating symptomatic non-typhoidal Salmonella infection / I.A.Onwuezobe, Р.О.Oshun, С.С.Odigwe // Cochrane Database Syst Rev. – 2012. – № 11. – P. 1167.Lee, H.-Y. Oral Cefixime is beneficial in acute uncomplicated Salmonella gastroenteritis in children with mucoid or bloody diarrhea – Do indications of antibiotics therapy need reassessment? / H.-Y.Lee [et al.] // 14th International Congress on Infectious Diseases (ICID) Abstracts. – International Journal of Infectious Diseases. – 2010. – V. 14, № 1. – С. 196–197.Lee, H.-Y. Oral Cefixime is beneficial in acute uncomplicated Salmonella gastroenteritis in children with mucoid or bloody diarrhea – Do indications of antibiotics therapy need reassessment? / H.-Y.Lee [et al.] // 14th International Congress on Infectious Diseases (ICID) Abstracts. – International Journal of Infectious Diseases. – 2010. – V. 14, № 1. – С. 196–197.Hohmann, E. Approach to the patient with nontyphoidal Salmonella in a stool culture / E. Hohmann // Literature review current through. – 2013. – http://www.uptodate.com/Hohmann, E. Approach to the patient with nontyphoidal Salmonella in a stool culture / E. Hohmann // Literature review current through. – 2013. – http://www.uptodate.com/Vukelic, D. Acute Infectious Gastroenterocolitis: Use or Not to Use Antibiotics? / D. Vukelic // 13th International Congress on Infectious Diseases, Abstracts. – International Journal of Infectious Diseases. – 2008. – V. 12, № 1. – P. 25–26.Vukelic, D. Acute Infectious Gastroenterocolitis: Use or Not to Use Antibiotics? / D. Vukelic // 13th International Congress on Infectious Diseases, Abstracts. – International Journal of Infectious Diseases. – 2008. – V. 12, № 1. – P. 25–26.Ternhag, A. A meta-analysis on the effects of antibiotic treatment on duration of symptoms caused by infection with Campylobacter species / A. Ternhag [et al.] // Clin Infect Dis. – 2007. – V. 44, № 5. –P. 696–700.Ternhag, A. A meta-analysis on the effects of antibiotic treatment on duration of symptoms caused by infection with Campylobacter species / A. Ternhag [et al.] // Clin Infect Dis. – 2007. – V. 44, № 5. –P. 696–700.Smith, K.Е. Antibiotic Treatment of Escherichia coli O157 Infection and the Risk of Hemolytic Uremic Syndrome, Minnesota / K.Е. Smith [et al.] // The Pediatric Infectious Disease Journal. – 2012. – V. 31, № 1. – P. 37–41.Smith, K.Е. Antibiotic Treatment of Escherichia coli O157 Infection and the Risk of Hemolytic Uremic Syndrome, Minnesota / K.Е. Smith [et al.] // The Pediatric Infectious Disease Journal. – 2012. – V. 31, № 1. – P. 37–41.Tarr, P.I. Shiga-toxin-producing Escherichia coli and haemolytic uremic syndrome / P.I. Tarr, C.A.Gordon, W.L.Chandler // Lancet. – 2005. – V. 365, № 9464. – P. 1073–1086.Tarr, P.I. Shiga-toxin-producing Escherichia coli and haemolytic uremic syndrome / P.I. Tarr, C.A.Gordon, W.L.Chandler // Lancet. – 2005. – V. 365, № 9464. – P. 1073–1086.Molbak, K. Antimicrobial therapy in patients with Escherichia coli O157:H7 infection / K. Molbak, P.S. Mead, P.M. Griffin // JAMA. – 2002. – V. 288, № 8. – С. 1014–1016.Molbak, K. Antimicrobial therapy in patients with Escherichia coli O157:H7 infection / K. Molbak, P.S. Mead, P.M. Griffin // JAMA. – 2002. – V. 288, № 8. – С. 1014–1016.Safdar, N. Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a metaanalysis / N.Safdar [et al.] // JAMA. – 2002. – V. 288, № 8. – P. 996–1001.Safdar, N. Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a metaanalysis / N.Safdar [et al.] // JAMA. – 2002. – V. 288, № 8. – P. 996–1001.Davidson, G. Infectious Diarrhea in Children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition / G. Davidson [et al.] // Journal of Pediatric Gastroenterology and Nutrition. – 2002. – V. 35, № 2. – P. 143-150.Davidson, G. Infectious Diarrhea in Children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition / G. Davidson [et al.] // Journal of Pediatric Gastroenterology and Nutrition. – 2002. – V. 35, № 2. – P. 143-150.Халиуллина, С.В. Антибиотикорезистентность современных возбудителей внебольничных бактериальных кишечных инфекций у детей / С.В.Халиуллина [и др.] // Практическая медицина. – 2010. – Т. 40, № 1. – С. 85–88.Халиуллина, С.В. Антибиотикорезистентность современных возбудителей внебольничных бактериальных кишечных инфекций у детей / С.В.Халиуллина [и др.] // Практическая медицина. – 2010. – Т. 40, № 1. – С. 85–88.Teran, C.G. Nitazoxanide vs. probiotics for the treatment of acute rotavirus diarrhea in children: a randomized, single-blind, controlled trial in Bolivian children / C.G. Teran, C.N. Teran-Escalera, P. Villarroel // Int J Infect Dis. – 2009. – V. 13, № 4. – P. 518–523.Teran, C.G. Nitazoxanide vs. probiotics for the treatment of acute rotavirus diarrhea in children: a randomized, single-blind, controlled trial in Bolivian children / C.G. Teran, C.N. Teran-Escalera, P. Villarroel // Int J Infect Dis. – 2009. – V. 13, № 4. – P. 518–523.Rossignol, J. Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebocontrolled trial / J.F. Rossignol [et al.] // Lancet. – 2006. – V. 368, № 9530. – P. 124–129.Rossignol, J. Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebocontrolled trial / J.F. Rossignol [et al.] // Lancet. – 2006. – V. 368, № 9530. – P. 124–129.Szajewska, H. Gastrointestinal infections in the pediatric population / H. Szajewska, P. Dziechciarz // Current Opinion in Gastroenterology. – 2010. – V. 26, № 1. – P. 36–44.Szajewska, H. Gastrointestinal infections in the pediatric population / H. Szajewska, P. Dziechciarz // Current Opinion in Gastroenterology. – 2010. – V. 26, № 1. – P. 36–44.Uhlen, S. Treatment of acute diarrhea: prescription patterns by private practice pediatricians / S. Uhlen, F. Toursel, F. Gottrand // Arch Pediatr. – 2004. – V. 11, № 8. – P. 903– 907.Uhlen, S. Treatment of acute diarrhea: prescription patterns by private practice pediatricians / S. Uhlen, F. Toursel, F. Gottrand // Arch Pediatr. – 2004. – V. 11, № 8. – P. 903– 907.Practice parameter: the management of acute gastroenteritis in young children. American academy of Pediatrics, Provisional Committee on Quality Improvement, Subcommittee on Acut Gastroenteritis / No authors listed // Pediatrics. – 1996. – V. 97, № 3. – P. 424–435.Practice parameter: the management of acute gastroenteritis in young children. American academy of Pediatrics, Provisional Committee on Quality Improvement, Subcommittee on Acut Gastroenteritis / No authors listed // Pediatrics. – 1996. – V. 97, № 3. – P. 424–435.Szajewska, H. Meta-analysis: smectite in the treatment of acute infectious diarrhoea in children / H. Szajewska, P. Dziechciarz, J. Mrukowicz // Aliment Pharmacol Ther. – 2006. – V. 23, № 2. – P. 217–227.Szajewska, H. Meta-analysis: smectite in the treatment of acute infectious diarrhoea in children / H. Szajewska, P. Dziechciarz, J. Mrukowicz // Aliment Pharmacol Ther. – 2006. – V. 23, № 2. – P. 217–227.Mujawar, Q.М. Efficacy of dioctahedral smectite in acute watery diarrhea in Indian children: a randomized clinical trial / Q.М. Mujawar [et al.] // J Trop Pediatr. – 2012. – V. 58, № 1. – P. 63–67.Mujawar, Q.М. Efficacy of dioctahedral smectite in acute watery diarrhea in Indian children: a randomized clinical trial / Q.М. Mujawar [et al.] // J Trop Pediatr. – 2012. – V. 58, № 1. – P. 63–67.Dupont, C. Peru and Malaysia Diosmectite Study Groups. Oral diosmectite reduces stool output and diarrhea duration in children with acute watery diarrhea / C. Dupont [et al.] // Clin Gastroenterol Hepatol. – 2009. – V. 7, № 4. – P. 456–462.Dupont, C. Peru and Malaysia Diosmectite Study Groups. Oral diosmectite reduces stool output and diarrhea duration in children with acute watery diarrhea / C. Dupont [et al.] // Clin Gastroenterol Hepatol. – 2009. – V. 7, № 4. – P. 456–462.Becker, B. Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin–chamomile extract in children with unspecific diarrhea / B. Becker, U. Kuhn, B. Hardewig-Budny // Arzneimittelforschung. – 2006. – V. 56, № 6. – P. 387–393.Becker, B. Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin–chamomile extract in children with unspecific diarrhea / B. Becker, U. Kuhn, B. Hardewig-Budny // Arzneimittelforschung. – 2006. – V. 56, № 6. – P. 387–393.De la Motte, S. Double-blind comparison of an apple pectin–chamomile extract preparation with placebo in children with diarrhea [in German] / S. De la Motte [et al.] // Arzneimittelforschung. – 1997. – V. 47, № 11. – P. 1247–1249.De la Motte, S. Double-blind comparison of an apple pectin–chamomile extract preparation with placebo in children with diarrhea [in German] / S. De la Motte [et al.] // Arzneimittelforschung. – 1997. – V. 47, № 11. – P. 1247–1249.Watkinson, M. A lack of therapeutic response to kaolin in acute childhood diarrhoea treated with glucose electrolyte solution / M.Watkinson // J Trop Pediatr. – 1982. – V. 28, № 6. – P. 306–307.Watkinson, M. A lack of therapeutic response to kaolin in acute childhood diarrhoea treated with glucose electrolyte solution / M.Watkinson // J Trop Pediatr. – 1982. – V. 28, № 6. – P. 306–307.Zeller, J. The use of actapulgite for the treatment of acute diarrhea in infants and children. Review of pediatric studies [in French] / J. Zeller, P.F. Bougneres // Ann Pediatr (Paris). – 1993. – V. 40, № 4. – P. 276–280.Zeller, J. The use of actapulgite for the treatment of acute diarrhea in infants and children. Review of pediatric studies [in French] / J. Zeller, P.F. Bougneres // Ann Pediatr (Paris). – 1993. – V. 40, № 4. – P. 276–280.Анохин, В.А. Ацетонемический синдром при острых кишечных инфекциях у детей / В.А. Анохин,Анохин, В.А. Ацетонемический синдром при острых кишечных инфекциях у детей / В.А. Анохин,С.В. Халиуллина, И.А. Гутор // Детские инфекции. – 2012. – № 1. – С. 6–12.С.В. Халиуллина, И.А. Гутор // Детские инфекции. – 2012. – № 1. – С. 6–12.Levine, D. Antiemetics for acute gastroenteritis in children / D.А. Levine // Current Opinion in Pediatrics. – 2009. –V. 21, № 3. – P. 294–298.Levine, D. Antiemetics for acute gastroenteritis in children / D.А. Levine // Current Opinion in Pediatrics. – 2009. –V. 21, № 3. – P. 294–298.Kan, K.К. Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew) /K.К. Kan [et al.] // Eur J Pharmacol. – 2003. – V. 482, № 1–3. – P. 297–304.Kan, K.К. Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew) /K.К. Kan [et al.] // Eur J Pharmacol. – 2003. – V. 482, № 1–3. – P. 297–304.Pfeil, N. Antiemetic medications in children with presumed infectious gastroenteritis–pharmacoepidemiology in Europe and Northern America / N. Pfeil [et al.] // J Pediatr. – 2008. – V. 153, № 5. – С. 659–662.Pfeil, N. Antiemetic medications in children with presumed infectious gastroenteritis–pharmacoepidemiology in Europe and Northern America / N. Pfeil [et al.] // J Pediatr. – 2008. – V. 153, № 5. – С. 659–662.Zanon, D. Off-label prescribing patterns of antiemetics in children: a multicenter study in Italy / D. Zanon [et al.] // Eur J Pediatr. – 2013. – V. 172, № 3. – P. 361–367.Zanon, D. Off-label prescribing patterns of antiemetics in children: a multicenter study in Italy / D. Zanon [et al.] // Eur J Pediatr. – 2013. – V. 172, № 3. – P. 361–367.Alhashimi, D. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / D. Alhashimi, H. Alhashimi, Z. Fedorowicz // Cochrane Database Syst Rev. – 2006. – V. 18, № 4. – P. 005506.Alhashimi, D. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / D. Alhashimi, H. Alhashimi, Z. Fedorowicz // Cochrane Database Syst Rev. – 2006. – V. 18, № 4. – P. 005506.Mehra, K. Hypersensitivity to intravenous ondansetron: a case report / K. Mehra [et al.] // J Med Case Reports. –2008. – V. 2. – P. 274.Mehra, K. Hypersensitivity to intravenous ondansetron: a case report / K. Mehra [et al.] // J Med Case Reports. –2008. – V. 2. – P. 274.Szajewska, H. Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children / H. Szajewska, D. Gieruszczak- Białek, M. Dylag // Aliment Pharmacol Ther. – 2007. – V. 25, № 4. – P. 393–400.Szajewska, H. Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children / H. Szajewska, D. Gieruszczak- Białek, M. Dylag // Aliment Pharmacol Ther. – 2007. – V. 25, № 4. – P. 393–400.Evidence-based care guideline for prevention and management of acute gastroenteritis (AGE) in children aged 2 months to 18 years. 1999 Nov (revised 2011 Dec 21). NGC:008846. – http://www.guideline.gov/content.aspx?id=35123&searchEvidence-based care guideline for prevention and management of acute gastroenteritis (AGE) in children aged 2 months to 18 years. 1999 Nov (revised 2011 Dec 21). NGC:008846. – http://www.guideline.gov/content.aspx?id=35123&searchFedorowicz, Z. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / Z. Fedorowicz, V.А. Jagannath, В. Carter // Cochrane Database Syst Rev. – 2011. – V. 7. – P. 005506.Fedorowicz, Z. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / Z. Fedorowicz, V.А. Jagannath, В. Carter // Cochrane Database Syst Rev. – 2011. – V. 7. – P. 005506.Levine D. Oral ondansetron decreases vomiting, as well as the need for intravenous fluids and hospital admission, in children with acute gastroenteritis / D. Levine // Evid Based Med. – 2012. – V. 17, № 4. – С. 112–113.Levine D. Oral ondansetron decreases vomiting, as well as the need for intravenous fluids and hospital admission, in children with acute gastroenteritis / D. Levine // Evid Based Med. – 2012. – V. 17, № 4. – С. 112–113.Carter, B. Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with metaanalysis and mixed treatment comparison in a Bayesian framework / В. Carter, Z. Fedorowicz // BMJ Open. – 2012. – V. 2, № 4. – P. 000622.Carter, B. Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with metaanalysis and mixed treatment comparison in a Bayesian framework / В. Carter, Z. Fedorowicz // BMJ Open. – 2012. – V. 2, № 4. – P. 000622.Freedman, S.В. Oral ondansetron for gastroenteritis in a pediatric emergency department / S.В. Freedman [et al.] //N Engl J Med. – 2006. – V. 354, № 16. – P. 1698-1705.Freedman, S.В. Oral ondansetron for gastroenteritis in a pediatric emergency department / S.В. Freedman [et al.] //N Engl J Med. – 2006. – V. 354, № 16. – P. 1698-1705.Bruzzese E. Hospital management of children with acute gastroenteritis / Е. Bruzzese, А. Lo Vecchio, А. Guarino // Curr Opin Gastroenterol. – 2013. – V. 29, № 1. – P. 23–30.Bruzzese E. Hospital management of children with acute gastroenteritis / Е. Bruzzese, А. Lo Vecchio, А. Guarino // Curr Opin Gastroenterol. – 2013. – V. 29, № 1. – P. 23–30.Al-Ansari, K. Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis / К. Al-Ansari [et al.] // J Pediatr Gastroenterol Nutr. – 2011. – V. 53, № 2. – P. 156–160.Al-Ansari, K. Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis / К. Al-Ansari [et al.] // J Pediatr Gastroenterol Nutr. – 2011. – V. 53, № 2. – P. 156–160.Alhashimi, D. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / D. Alhashimi, H. Al-Hashimi, Z. Fedorowicz // Cochrane Database Syst Rev. – 2009. – № 2. – P. 005506. Review. Update in: Cochrane Database Syst Rev. – 2011. – № 9. – P. 005506.Alhashimi, D. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / D. Alhashimi, H. Al-Hashimi, Z. Fedorowicz // Cochrane Database Syst Rev. – 2009. – № 2. – P. 005506. Review. Update in: Cochrane Database Syst Rev. – 2011. – № 9. – P. 005506.Alhashimi, D. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / D. Alhashimi, H. Al-Hashimi, Z. Fedorowicz // Cochrane Database Syst Rev. – 2006. – № 4. – C. 005506. Review. Update in: Cochrane Database Syst Rev. – 2009. – № 2. – C. 005506.Alhashimi, D. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents / D. Alhashimi, H. Al-Hashimi, Z. Fedorowicz // Cochrane Database Syst Rev. – 2006. – № 4. – C. 005506. Review. Update in: Cochrane Database Syst Rev. – 2009. – № 2. – C. 005506.Запруднов, А.М. Моторно-эвакуаторные нарушения пищеварительного тракта и применение прокинетиков в детском возрасте / А.М. Запруднов // Рус. мед. журнал. Болезни пищеварительной системы. – 2006. – № 8. – C. 22–31.Запруднов, А.М. Моторно-эвакуаторные нарушения пищеварительного тракта и применение прокинетиков в детском возрасте / А.М. Запруднов // Рус. мед. журнал. Болезни пищеварительной системы. – 2006. – № 8. – C. 22–31.Багненко, С.Ф. Методы фармакологической коррекции двигательно-эвакуаторных нарушений желудка и двенадцатиперстной кишки / С.Ф. Багненко, Е.В. Назаров, М.Ю. Кабанов // Рус. мед. журнал. Болезни органов пищеварения. – 2004. – № 1. – С. 19–23.Багненко, С.Ф. Методы фармакологической коррекции двигательно-эвакуаторных нарушений желудка и двенадцатиперстной кишки / С.Ф. Багненко, Е.В. Назаров, М.Ю. Кабанов // Рус. мед. журнал. Болезни органов пищеварения. – 2004. – № 1. – С. 19–23.Roy, P. A comparison of controlled release metoclopramide and domperidone in the treatment of nausea andvomiting / P. Roy, N.Н. Patel, A.J. Miller // British Journal of Clinical Practice. – 1991. – V. 45, № 4. – P. 247–251.Roy, P. A comparison of controlled release metoclopramide and domperidone in the treatment of nausea andvomiting / P. Roy, N.Н. Patel, A.J. Miller // British Journal of Clinical Practice. – 1991. – V. 45, № 4. – P. 247–251.Van Eygen, М. A double-blind comparison of domperidone and metoclopramide suppositories in the treatment of nausea and vomiting in children / М.Van Eygen [et al.] // Postgraduate Medical Journal. – 1979. – V. 55, № 1. – P. 36–39.Van Eygen, М. A double-blind comparison of domperidone and metoclopramide suppositories in the treatment of nausea and vomiting in children / М.Van Eygen [et al.] // Postgraduate Medical Journal. – 1979. – V. 55, № 1. – P. 36–39.DeCamp, L.R. Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis / L.R. DeCamp [et al.] // Arch Pediatr Adolesc Med. – 2008. – V. 162, № 9. – P. 858–865.DeCamp, L.R. Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis / L.R. DeCamp [et al.] // Arch Pediatr Adolesc Med. – 2008. – V. 162, № 9. – P. 858–865.Leung, A.К. Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting /A.К. Leung, W.L. Robson // Paediatr Drugs. – 2007. – V. 9, № 3. – P. 175–184.Leung, A.К. Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting /A.К. Leung, W.L. Robson // Paediatr Drugs. – 2007. – V. 9, № 3. – P. 175–184.DuPont, H.L. Systematic review: the epidemiology and clinical features of travellers’ diarrhoea / Н.L. DuPont // Aliment Pharmacol Ther. – 2009. – V. 30, № 3. – V. 187–196.DuPont, H.L. Systematic review: the epidemiology and clinical features of travellers’ diarrhoea / Н.L. DuPont // Aliment Pharmacol Ther. – 2009. – V. 30, № 3. – V. 187–196.Wingate, D. Guidelines for adults on self-medication for the treatment of acute diarrhea / D. Wingate [et al.] // Aliment Pharmacol Ther. – 2001. – V. 15, № 6. – P. 773–782.Wingate, D. Guidelines for adults on self-medication for the treatment of acute diarrhea / D. Wingate [et al.] // Aliment Pharmacol Ther. – 2001. – V. 15, № 6. – P. 773–782.Nelson, J.М. Antimicrobial and antimotility agent use in persons with shiga toxin-producing Escherichia coli O157 infection in FoodNet Sites / J.M. Nelson [et al.] // Clin Infect Dis. – 2011. – V. 52, № 9. – P. 1130–1132.Nelson, J.М. Antimicrobial and antimotility agent use in persons with shiga toxin-producing Escherichia coli O157 infection in FoodNet Sites / J.M. Nelson [et al.] // Clin Infect Dis. – 2011. – V. 52, № 9. – P. 1130–1132.Dalby-Payne, J.R. Gastroenteritis in children / J.R. Dalby-Payne, Е.J. Elliott // Clin Evid (Online). – 2009.Dalby-Payne, J.R. Gastroenteritis in children / J.R. Dalby-Payne, Е.J. Elliott // Clin Evid (Online). – 2009.Li, S.Т. Loperamide therapy for acute diarrhea in children: Systematic review and meta-analysis / S.Т. Li, D.С. Grossman, P. Cummings // PLoS Med. – 2007. – V. 4, № 3. – P. 495–505.Li, S.Т. Loperamide therapy for acute diarrhea in children: Systematic review and meta-analysis / S.Т. Li, D.С. Grossman, P. Cummings // PLoS Med. – 2007. – V. 4, № 3. – P. 495–505.Eberlin, M. A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral ndopeptidase inhibitor racecadotril / M. Eberlin, T. Mück, M.С. Michel // Front Pharmacol. – 2012. – № 3. – P. 93.Eberlin, M. A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral ndopeptidase inhibitor racecadotril / M. Eberlin, T. Mück, M.С. Michel // Front Pharmacol. – 2012. – № 3. – P. 93.Salazar-Lindo, E. Racecadotril in the treatment of acute watery diarrhea in children / E. Salazar-Lindo [et al.] // N Engl J Med. – 2000. – V. 343, № 7. – С. 463–467.Salazar-Lindo, E. Racecadotril in the treatment of acute watery diarrhea in children / E. Salazar-Lindo [et al.] // N Engl J Med. – 2000. – V. 343, № 7. – С. 463–467.Faure C. Role of antidiarrhoeal drugs as adjunctive therapies for acute diarrhoea in children / C. Faure // Int J Pediatr. – 2013. – V. 27, № 5.– 612403.Faure C. Role of antidiarrhoeal drugs as adjunctive therapies for acute diarrhoea in children / C. Faure // Int J Pediatr. – 2013. – V. 27, № 5.– 612403.Tormo, R. Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril / R.Tormo [et al.] // Acta Paediatr. – 2008. – V. 97, № 8. – P. 1008–1015.Tormo, R. Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril / R.Tormo [et al.] // Acta Paediatr. – 2008. – V. 97, № 8. – P. 1008–1015.Cezard, J.Р. Efficacy and tolerability of racecadotril in acute diarrhea in children / J.Р.Cezard [et al.] // Gastroenterology. – 2001. – V. 120, № 4. – P. 799–805.Cezard, J.Р. Efficacy and tolerability of racecadotril in acute diarrhea in children / J.Р.Cezard [et al.] // Gastroenterology. – 2001. – V. 120, № 4. – P. 799–805.Cojocaru, B. Effect of racecadotril in the management of acute diarrhea in infants and children [in French] / J. Cezard [et al.] // Arch Pediatr. – 2002. – V. 9, № 8. – P. 774–779.Cojocaru, B. Effect of racecadotril in the management of acute diarrhea in infants and children [in French] / J. Cezard [et al.] // Arch Pediatr. – 2002. – V. 9, № 8. – P. 774–779.Lehert, P. Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis / P. Lehert, G. Chéron, G.А. Calatayud // Dig Liver Dis. – 2011. – V. 43, № 9. – P. 707–713.Lehert, P. Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis / P. Lehert, G. Chéron, G.А. Calatayud // Dig Liver Dis. – 2011. – V. 43, № 9. – P. 707–713.Rautenberg, T.А. Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model / Т.А. Rautenberg [et al.] // Clinicoecon Outcomes Res. – 2012. – № 4. – P. 109–116.Rautenberg, T.А. Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model / Т.А. Rautenberg [et al.] // Clinicoecon Outcomes Res. – 2012. – № 4. – P. 109–116.Gallelli, L. Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes / L. Gallelli, M. Colosimo, G.А. Tolotta // Eur J Clin Pharmacol. – 2010. – V. 66, № 2. – P. 137–144.Gallelli, L. Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes / L. Gallelli, M. Colosimo, G.А. Tolotta // Eur J Clin Pharmacol. – 2010. – V. 66, № 2. – P. 137–144.Guarino, A. Which place for bismuth subsalicylate in the treatment of enteric infections? / А. Guarino, Е. Bruzzese //Acta Paediatr. – 2001. – V. 90, № 6. – P. 601–604.Guarino, A. Which place for bismuth subsalicylate in the treatment of enteric infections? / А. Guarino, Е. Bruzzese //Acta Paediatr. – 2001. – V. 90, № 6. – P. 601–604.Connor, B.А. Prevention and treatment of acute traveler's diarrhea / B.А. Connor, B. Landzberg // Infect Med. –2004. – V. 21, № 1. – P. 18–19.Connor, B.А. Prevention and treatment of acute traveler's diarrhea / B.А. Connor, B. Landzberg // Infect Med. –2004. – V. 21, № 1. – P. 18–19.Gottlieb, T. Diarrhoea in adults (acute) / T. Gottlieb, C.S. Heather // Clin Evid (Online). – 2011. – V. 27, № 11.– 0901.Gottlieb, T. Diarrhoea in adults (acute) / T. Gottlieb, C.S. Heather // Clin Evid (Online). – 2011. – V. 27, № 11.– 0901.Steffen, R. Travelers’ diarrhea in West Africa and Mexico: fecal transport systems and liquid bismuth subsalicylate for elf-therapy / R. Steffen [et al.] // J Infect Dis. – 1988. – V. 157, № 5. – P. 1008–1013.Steffen, R. Travelers’ diarrhea in West Africa and Mexico: fecal transport systems and liquid bismuth subsalicylate for elf-therapy / R. Steffen [et al.] // J Infect Dis. – 1988. – V. 157, № 5. – P. 1008–1013.Johnson, P.С. Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers’ diarrhea /P.С. Johnson [et al.] // JAMA. – 1986. – V. 255, № 6. – P. 757–760.Johnson, P.С. Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers’ diarrhea /P.С. Johnson [et al.] // JAMA. – 1986. – V. 255, № 6. – P. 757–760.DuPont, H.L. Comparative efficacy of loperamide hydrochloride and bismuth subsalicylate in the management of acute diarrhea / H.L. DuPont [et al.] // Am J Med. – 1990. – V. 88, № 6А. – P. 15–19.DuPont, H.L. Comparative efficacy of loperamide hydrochloride and bismuth subsalicylate in the management of acute diarrhea / H.L. DuPont [et al.] // Am J Med. – 1990. – V. 88, № 6А. – P. 15–19.Chowdhury, H.R. The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhea / H.R. Chowdhury [et al.] // Acta Paediatr. – 2001. – V. 90, № 6. – P. 605–610.Chowdhury, H.R. The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhea / H.R. Chowdhury [et al.] // Acta Paediatr. – 2001. – V. 90, № 6. – P. 605–610.Реализация новых рекомендаций по клиническому ведению диареи : pуководство для лиц, ответственных за принятие решений и программных менеджеров. – ВОЗ, 2012. – www.euro.who.int/__data/assets/pdf_file/0007/.../9244594218R.pdf.Реализация новых рекомендаций по клиническому ведению диареи : pуководство для лиц, ответственных за принятие решений и программных менеджеров. – ВОЗ, 2012. – www.euro.who.int/__data/assets/pdf_file/0007/.../9244594218R.pdf.Pieścik-Lech, M. Review Article: The Management of Acute Gastroenteritis in Children / M. Pieścik-Lech [et al.] //Aliment Pharmacol Ther. – 2013. – V. 37, № 3. – P. 289–303.Pieścik-Lech, M. Review Article: The Management of Acute Gastroenteritis in Children / M. Pieścik-Lech [et al.] //Aliment Pharmacol Ther. – 2013. – V. 37, № 3. – P. 289–303.Patro, B. Meta-analysis: zinc supplementation for acute gastroenteritis in children / B. Patro, D. Golicki, H. Szajewska // Aliment Pharmacol Ther. – 2008. – V. 28, № 6. – P. 713–723.Patro, B. Meta-analysis: zinc supplementation for acute gastroenteritis in children / B. Patro, D. Golicki, H. Szajewska // Aliment Pharmacol Ther. – 2008. – V. 28, № 6. – P. 713–723.Patel, A. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review / A. Patel [et al.] // PLoS. One. – 2010. – V. 5, № 4. – P. 10386.Patel, A. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review / A. Patel [et al.] // PLoS. One. – 2010. – V. 5, № 4. – P. 10386.Lazzerini, M. Oral zinc for treating diarrhoea in children / M. Lazzerini, L. Ronfani // CochraneDatabase Syst Rev. – 2013. – № 6. – P. 005436.Lazzerini, M. Oral zinc for treating diarrhoea in children / M. Lazzerini, L. Ronfani // CochraneDatabase Syst Rev. – 2013. – № 6. – P. 005436.Patro, B. Oral zinc for the treatment of acute gastroenteritis in Polish children: a randomized, double-blind, placebocontrolled trial / B. Patro, H. Szyma ski, H. Szajewska // J Pediatr. – 2010. – V. 157, № 6. – P. 984–988.Patro, B. Oral zinc for the treatment of acute gastroenteritis in Polish children: a randomized, double-blind, placebocontrolled trial / B. Patro, H. Szyma ski, H. Szajewska // J Pediatr. – 2010. – V. 157, № 6. – P. 984–988.Abrams, S. Zinc deficiency and supplementation in children and adolescents / S. Abrams. – http://www.uptodate. com/contents/zinc-deficiency-and-supplementation-in-children- and-adolescents/contributors.Abrams, S. Zinc deficiency and supplementation in children and adolescents / S. Abrams. – http://www.uptodate. com/contents/zinc-deficiency-and-supplementation-in-children- and-adolescents/contributors.Canani, R.В. Zinc inhibits cholera toxin-induced, but not Escherichia coli heat-stable enterotoxin-induced, ion secretion in human enterocytes / R.В. Canani [et al.]// J Infect Dis. – 2005. – V.191, № 7. – P. 1072–1077.Canani, R.В. Zinc inhibits cholera toxin-induced, but not Escherichia coli heat-stable enterotoxin-induced, ion secretion in human enterocytes / R.В. Canani [et al.]// J Infect Dis. – 2005. – V.191, № 7. – P. 1072–1077.Crane, J.K. Effect of zinc in enteropathogenic Escherichia coli infection / J.K. Crane [et al.] // Infect Immun. –2007. – V. 75, № 12. – P. 5974–5984.Crane, J.K. Effect of zinc in enteropathogenic Escherichia coli infection / J.K. Crane [et al.] // Infect Immun. –2007. – V. 75, № 12. – P. 5974–5984.Вrown, K.Н. Zinc fortification of cereal flours: current recommendations and research needs / K.Н. Вrown, K.М. Hambidge, P. Ranum // Food Nutr Bull. – 2010. – V. 31, № 1. – P. 62–74.Вrown, K.Н. Zinc fortification of cereal flours: current recommendations and research needs / K.Н. Вrown, K.М. Hambidge, P. Ranum // Food Nutr Bull. – 2010. – V. 31, № 1. – P. 62–74.Allen, S.J. Probiotics for treating acute infectious diarrhoea (Review) / S.J. Allen [et al.] // Cochrane Database Syst Rev. – 2010. – V. 10, № 11. – P. 003048.Allen, S.J. Probiotics for treating acute infectious diarrhoea (Review) / S.J. Allen [et al.] // Cochrane Database Syst Rev. – 2010. – V. 10, № 11. – P. 003048.Weizman, Z. Probiotics Use in Childhood Acute Diarrhea: A Web-based Survey / Z.Weizman // Journal of Clinical Gastroenterology. – 2011. – V. 45, № 5. – P. 426–428.Weizman, Z. Probiotics Use in Childhood Acute Diarrhea: A Web-based Survey / Z.Weizman // Journal of Clinical Gastroenterology. – 2011. – V. 45, № 5. – P. 426–428.Best evidence statement (BESt). Use of Lactobacillus rhamnosus GG in children with acute gastroenteritis. – http://www.guidelines.gov/content.aspx?id=33576&search=probioticsBest evidence statement (BESt). Use of Lactobacillus rhamnosus GG in children with acute gastroenteritis. – http://www.guidelines.gov/content.aspx?id=33576&search=probioticsSzajewska, H. Advances and limitations of evidencebased medicine – impact for probiotics / H. Szajewska // Ann Nutr Metab. – 2010. – № 57. – P. 6–9.Szajewska, H. Advances and limitations of evidencebased medicine – impact for probiotics / H. Szajewska // Ann Nutr Metab. – 2010. – № 57. – P. 6–9.Szajewska, H. Probiotics in the Treatment and Prevention of Acute Infectious Diarrhea in Infants and Children: A Systematic Review of Published Randomized, Double-Blind, Placebo- Controlled Trials / H. Szajewska, J.Z. Mrukowicz // Journal of Pediatric Gastroenterology and Nutrition. – 2001. – V. 33, № 2. – P. 17–25.Szajewska, H. Probiotics in the Treatment and Prevention of Acute Infectious Diarrhea in Infants and Children: A Systematic Review of Published Randomized, Double-Blind, Placebo- Controlled Trials / H. Szajewska, J.Z. Mrukowicz // Journal of Pediatric Gastroenterology and Nutrition. – 2001. – V. 33, № 2. – P. 17–25.Riaz, M. Efficacy and safety of Saccharomyces boulardii in acute childhood diarrhea: a double blind randomised controlled rial / M. Riaz [et al.] // Indian J Pediatr. – 2012. – V. 79, № 4. – P. 478–482.Riaz, M. Efficacy and safety of Saccharomyces boulardii in acute childhood diarrhea: a double blind randomised controlled rial / M. Riaz [et al.] // Indian J Pediatr. – 2012. – V. 79, № 4. – P. 478–482.Corrêa, N.В. Treatment of acute diarrhea with Saccharomyces boulardii in infants / N.В. Corrêa [et al.] // J Pediatr Gastroenterol Nutr. – 2011. – V. 53, № 5. – P. 497–501.Corrêa, N.В. Treatment of acute diarrhea with Saccharomyces boulardii in infants / N.В. Corrêa [et al.] // J Pediatr Gastroenterol Nutr. – 2011. – V. 53, № 5. – P. 497–501.Szajewska, H. Saccharomyces boulardii for treating acute gastroenteritis in children: updated meta-analysis of randomized controlled trials / H. Szajewska, A. Skórka // Aliment Pharmacol Ther. – 2009. – V. 30, № 9. – P. 960–961.Szajewska, H. Saccharomyces boulardii for treating acute gastroenteritis in children: updated meta-analysis of randomized controlled trials / H. Szajewska, A. Skórka // Aliment Pharmacol Ther. – 2009. – V. 30, № 9. – P. 960–961.Dinleyici, E.С. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea / E.С. Dinleyici [et al.] // Expert Opin BiolTher. – 2012. – V. 12, № 4. – P. 395–410.Dinleyici, E.С. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea / E.С. Dinleyici [et al.] // Expert Opin BiolTher. – 2012. – V. 12, № 4. – P. 395–410.Francavilla, R. Randomised clinical trial: Lactobacillus reuteri DSM 17938 vs. placebo in children with acute diarrhoea – a double-blind study / R. Francavilla [et al.] // Aliment Pharmacol Ther. – 2012. – V. 36, № 4. – P. 363–369.Francavilla, R. Randomised clinical trial: Lactobacillus reuteri DSM 17938 vs. placebo in children with acute diarrhoea – a double-blind study / R. Francavilla [et al.] // Aliment Pharmacol Ther. – 2012. – V. 36, № 4. – P. 363–369.

The authors declare that there are no conflicts of interest present.