jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2011-3-2-28-32jofin-18Research ArticleЛекцииLecturesИММУНОПАТОГЕНЕЗ ИНФЕКЦИОННО-ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫImmunopathogenesis of infectious-inflammatory diseases of central nervous systemЖелезниковаГ. Ф.ZheleznikovaG. F.

руководитель лаборатории иммунологии и аллергологии отдела клинической лабораторной диагностики Научно-исследовательского института детских инфекций ФМБА России, д.м.н. профессор, тел. 8(812)234-90-06

zheleznikova.galina@gmail.comСкрипченкоН. В.SkripchenkoN. V.

заместитель директора по научной работе Научно-исследовательского института детских инфекций ФМБА России, д.м.н. профессор, тел. 8(812)234-90-06

rmtc@mail.ruНаучно-исследовательский институт детских инфекций ФМБА России, Санкт-ПетербургРоссияResearch Institute of Children Infections, FMBA Russia, Saint-PetersburgRussian Federation201105072014322832Copyright © Железникова Г.Ф., Скрипченко Н.В., 20142014Железникова Г.Ф., Скрипченко Н.В.Zheleznikova G.F., Skripchenko N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/18

В обзоре даны современные представления о роли резидентных клеток ЦНС (астроциты, микроглия) в развитии врожденного иммунного ответа при проникновении в мозг возбудителя или его антигенов. Описан механизм распознавания возбудителя «паттерн распознающими» (Toll-подобными) рецепторами клеток нейроглии и продукция этими клетками как медиаторов воспаления, включая провоспалительные цитокины, так и факторов негативной регуляции воспаления, защищающих ЦНС от повреждения и дегенерации.

The revue includes the contemporary information about the role of resident cells of the CNS (astrocytes, microglia) in development of innate immune response against pathogen (or its products) invasion in the brain. The detection of invading pathogens by pattern-recognition (Toll-like) receptors of neuroglia is described. Also is described the production by these cells of inflammatory mediators, including proinflammatory cytokines, as well as inflammation downregulating factors that protect the CNS from alteration and degeneration.

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The authors declare that there are no conflicts of interest present.