jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2011-3-2-21-27jofin-17Research ArticleЛекцииLecturesГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ ИММУНОГЕННОЙ СИГНАЛЬНОЙ СИСТЕМЫGenetic polymorphism of immunogenic signaling systemЦыганВ. Н.TzyganV. N.

начальник научно-исследовательского отдела Военно-медицинской академии им. С.М. Кирова, д.м.н., профессор, тел. +7-911-950-23-50

vn-t@mail.ruИвановА. М.IvanovA. M.

начальник отдела нанобиотехнологий НИЦ Военно-медицинской академии им. С.М. Кирова, д.м.н., профессор, тел. +7921-951-64-39

iamvma@mail.ruКамиловаТ. А.KamilovaT. A.

старший научный сотрудник лаборатории молекулярно-генетических исследований отдела нанобиотехнологий НИЦ Военно-медицинской академии им. С.М. Кирова, к.б.н., тел. +7921-637-46-51

kamilovaspb@mail.ruКожуховаЕ. А.КоjuhovaE. A.

доцент кафедры инфекционных болезней Санкт-Петербургского государственного медицинского университета им. академика И.П. Павлова, к.м.н., тел.+7-905-221-05-98

МурашкинН. Н.МurashkinN. N.

заведующий детским отделением ГУЗ «Клинический кожно-венерологический диспансер» департамента здравоохранения Краснодарского края, к.м.н., тел.+7-918-495-11-22

ЦыганН. В.TsyganN. V.

преподаватель кафедры нервных болезней Военно-медицинской академии, к.м.н., тел.+7-921-928-94-70

tn@live.ruВоенно-медицинская академия им. С.М. Кирова, Санкт-ПетербургРоссияMilitary Medical Academy by S.M. Kirov, S.PetersburgRussian Federation201104092014322127Copyright © Цыган В.Н., Иванов А.М., Камилова Т.А., Кожухова Е.А., Мурашкин Н.Н., Цыган Н.В., 20142014Цыган В.Н., Иванов А.М., Камилова Т.А., Кожухова Е.А., Мурашкин Н.Н., Цыган Н.В.Tzygan V.N., Ivanov A.M., Kamilova T.A., Коjuhova E.A., Мurashkin N.N., Tsygan N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/17

Функциональные исследования выявили важное значение структурной целостности компонентов внутриклеточной сигнальной трансдукции системы врожденного иммунитета. Идентифицирована молекулярная структура ряда протеинов, участвующих в иммунном сигналинге, что способствует пониманию механизмов функционирования врожденного иммунитета на молекулярном уровне. Полиморфизмы, изменяющие сигнальную трансдукцию в клеточных элементах врожденного иммунитета и влияющие на предрасположенность человека к различным инфекциям, являются еще одним доказательством роли генетического фона хозяина в патофизиологии инфекционных заболеваний или резистентности к ним. В лекции описаны полиморфизмы молекул, вовлеченных в иммуногенный сигналинг, которые ассоциированы с продукцией провоспалительных цитокинов и эффективностью иммунных реакций.

The functional studies underline the importance of maintaining structural integrity of the innate immune components of intracellular signaling. The molecular structures for a number of proteins and protein domains in immune signaling have been determined. These structures have assisted us in understanding innate immunity at the molecular level. A polymorphisms modulating innate immunity signal transduction has recently been shown to influence human susceptibility to many different infections, providing one more indication of the potential of host genetics to reveal physiological pathways and mechanisms that influence resistance to infectious diseases. This lection describes recently determined structures involved in TLR signaling.

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The authors declare that there are no conflicts of interest present.