jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2024-16-3-96-104jofin-1667Research ArticleОригинальные исследованияOriginal ResearchСодержание TGF-β1 в сыворотке крови у детей при новой коронавирусной инфекции COVID-19Blood serum TGF-β1 content in children with new coronavirus infectionБогомоловаИ. К.BogomolovaI. K.

Богомолова Ирина Кимовна – заведующая кафедрой педиатрии лечебного и стоматологического факультетов, д.м.н., профессор

тел.: 8(3022)35-43-24 доб. 164 

 Чита 

 Chita

bogomolova_ik@mail.ruПерегоедоваВ. Н.PeregoedovaV. N.

Перегоедова Валентина Николаевна – доцент кафедры педиатрии лечебного и стоматологического факультетов, к.м.н.

тел.: 8(3022)35-43-24 доб. 164 

Чита 

 Chita

v.peregoedova@mail.ruЧитинская государственная медицинская академияРоссияChita State Medical AcademyRussian Federation20242209202416396104Copyright © Богомолова И.К., Перегоедова В.Н., 20242024Богомолова И.К., Перегоедова В.Н.Bogomolova I.K., Peregoedova V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1667

Нарушение продукции TGF-β1 сыворотки крови является одним из предполагаемых механизмов новой коронавирусной инфекции 2019 г. (COVID-19).Цель: изучить содержание TGF-β1 сыворотки крови детей при новой коронавирусной инфекции COVID-19.Материалы и методы: одноцентровое одномоментное исследование проведено среди детей от 0 до 17 лет: 119 пациентов с COVID-19 (46,2% (55/119) девочек, 53,8% (64/119) мальчиков) и сопоставлено со 118 здоровыми детьми (53,4% (63/118) девочек, 46,6% (55/118) мальчиков) в качестве контрольной группы. Исследование проведено с апреля по июль 2020 г. Медиана возраста пациентов с новой коронавирусной инфекцией COVID-19 составила 11,0 [9,8; 11,0], здоровых детей – 11,0 [10,1; 11,0] лет. Дети с новой коронавирусной инфекцией COVID-19 разделены на подгруппы с бессимптомной (n=23), легкой (n=61) и среднетяжелой (n=35) формами. Образцы сыворотки на анализ концентрации TGF-β1 взяты у всех пациентов и определены методом проточной флюориметрии.Результаты: независимо от формы тяжести медиана уровня TGF-β1 сыворотки крови детей 0–17 лет с новой коронавирусной инфекцией COVID-19 составила 1340,8 [1340,5; 1632,8] пг/мл, что статистически значимо выше, чем в контрольной группе 8,7 [8,3; 17,0] пг/мл (p<0,001). Сывороточная концентрация TGF-β1 у детей до 6 лет с COVID-19 увеличена относительно школьников (1722,6 [1720,5; 2516,3] против 1231,3 [1229,9; 1487,9] пг/мл, p=0,006). Дети 0–6 лет со среднетяжелой формой COVID-19 имели высокие показатели TGF-β1 сыворотки крови (1896,3 [1876,1; 3329,9] пг/мл) при сравнении с пациентами 7–17 лет (1139,4 [1138,1; 1526,7]; p=0,023).Заключение: повышенные уровни TGF-β1 сыворотки крови зарегистрированы у детей с COVID-19 как при бессимптомной форме, так и с симптомами новой коронавирусной инфекции COVID-19, достигая максимальных значений при среднетяжелой форме у детей 0–6 лет.

Impaired serum TGF-β1 production is one of the proposed mechanisms for coronavirus disease 2019 (COVID-19).Study objective: to study blood serum TGF-β1 content in children with new coronavirus infection.Materials and methods: a one-stage study was conducted in 119 patients with COVID-19 and compared with 118 healthy children of the same age and sex as a control group. The age range in both groups was 11.0 years. Preschoolers (0–6 years old) and schoolchildren (7–17 years old) in the group with COVID-19 were 21 (18%) and 98 (82%), respectively. Children with COVID-19 were divided into asymptomatic (n=23), mild (n=61), and moderate (n=35) subgroups. Serum samples for TGF-β1 concentration analysis were taken from all patients and tested by flow fluorimetry. The data were processed using the IBM SPSS Statistics Version 25.0 software package (International Business Machines Corporation, license No Z125-3301-14, USA).Results: median serum TGF-β1 levels of children 0–17 years old with COVID-19 regardless of the form of severity were significantly higher than in the control group. The serum concentration of TGF-β1 in children with COVID-19 of preschool age was increased comparing to schoolchildren. Children 0-6 years old with a moderate form of coronavirus infection had high serum TGF-β1 values when compared with school-age patients.Conclusion: elevated serum TGF-β1 levels were found in children both without clinical manifestations and with symptoms of coronavirus infection, reaching maximum values in the moderate form in children 0–6 years old.

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The authors declare that there are no conflicts of interest present.