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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2024-16-3-17-23</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-1658</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Диагностика хронического Лайм-боррелиоза, протекающего с поражением нервной системы</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis of chronic lyme borreliosis involving the nervous system</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богданова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogdanova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богданова Татьяна Владимировна – студентка </p><p>тел.: 8(831)422-21-17</p><p>Нижний Новгород </p></bio><bio xml:lang="en"><p> Nizhny Novgorod </p></bio><email xlink:type="simple">tbgdnv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рюмин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Rjumin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рюмин Александр Михайлович – доцент кафедры инфекционных болезней, к.м.н.</p><p>тел.: 8(831)422-21-17</p><p>Нижний Новгород  </p></bio><bio xml:lang="en"><p> Nizhny Novgorod </p></bio><email xlink:type="simple">infbol_8@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соболевская</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Sobolevskaja</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соболевская Оксана Львовна – профессор кафедры инфекционных болезней, д.м.н.</p><p>тел.: 8(831)422-21-17</p><p>Нижний Новгород </p></bio><bio xml:lang="en"><p> Nizhny Novgorod </p></bio><email xlink:type="simple">sol5584@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Приволжский исследовательский медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Privolzhsky Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>21</day><month>09</month><year>2024</year></pub-date><volume>16</volume><issue>3</issue><fpage>17</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Богданова Т.В., Рюмин А.М., Соболевская О.Л., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Богданова Т.В., Рюмин А.М., Соболевская О.Л.</copyright-holder><copyright-holder xml:lang="en">Bogdanova T.V., Rjumin A.M., Sobolevskaja O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/1658">https://journal.niidi.ru/jofin/article/view/1658</self-uri><abstract><p>Диагностика хронического Лайм-боррелиоза является трудной задачей для клинициста даже при наличии в его распоряжении современной лабораторной и инструментальной базы. Для боррелиоза характерна полисистемность и вариабельность проявлений. В данной статье рассмотрена клиника и диагностика хронического боррелиоза с поражением преимущественно центральной нервной системы. Рассмотрены различные клинические варианты заболевания и доступные методы специфической и неспецифической диагностики. Теоретическая часть работы выполнена по материалам 10 отечественных и 24 зарубежных публикаций, посвященных проблеме хронического нейроборрелиоза.</p></abstract><trans-abstract xml:lang="en"><p>Diagnosis of chronic Lyme disease is a challange for a clinician, even if there is modern laboratory and instrumental facilities at the hospital. Borreliosis is known for polysystemic and variable clinical picture. This article describes the clinical feachures and diagnosis of chronic borreliosis with central nervous system involvement. Various clinical variants of the disease and available methods of specific and nonspecific diagnosis are listed. The theoretical part of the work was carried out based on materials from 34 publications devoted to the problem of chronic neuroborreliosis. Also we describe the clinical case that illustrates the difficulties of managing this group of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нейроборрелиоз</kwd><kwd>Лайм-боррелиоз</kwd><kwd>post-treatment-синдром</kwd><kwd>энцефалопатия</kwd><kwd>менингорадикулоневрит</kwd><kwd>гидроцефалия нормального давления</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neuroborreliosis</kwd><kwd>Lyme disease</kwd><kwd>post-treatment syndrome</kwd><kwd>encephalopathy</kwd><kwd>meningoradiculoneuritis</kwd><kwd>normal pressure hydrocephalu</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wormser GP, Shapiro ED. Implications of gender in chronic Lyme disease. J Womens Health (Larchmt). 2009 Jun;18(6):831-4. URL: https://pubmed.ncbi.nlm.nih.gov/19514824/</mixed-citation><mixed-citation xml:lang="en">Wormser GP, Shapiro ED. Implications of gender in chronic Lyme disease. J Womens Health (Larchmt). 2009 Jun;18(6):831-4. URL: https://pubmed.ncbi.nlm.nih.gov/19514824/</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ali A, Vitulano L, Lee R, Weiss TR, Colson ER. Experiences of patients identifying with chronic Lyme disease in the healthcare system: a qualitative study. BMC Fam Pract. 2014 May 1;15:79. URL: https://pubmed.ncbi.nlm.nih.gov/24885888/</mixed-citation><mixed-citation xml:lang="en">Ali A, Vitulano L, Lee R, Weiss TR, Colson ER. Experiences of patients identifying with chronic Lyme disease in the healthcare system: a qualitative study. BMC Fam Pract. 2014 May 1;15:79. URL: https://pubmed.ncbi.nlm.nih.gov/24885888/</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Haugeberg G, Hansen IJ, Skarpaas T, Noraas S, Kjelland V. Lyme arthritis in Southern Norway--an endemic area for Lyme borreliosis. BMC Infect Dis. 2014 Apr 5;14:185. URL: https://pubmed.ncbi.nlm.nih.gov/24708707/</mixed-citation><mixed-citation xml:lang="en">Haugeberg G, Hansen IJ, Skarpaas T, Noraas S, Kjelland V. Lyme arthritis in Southern Norway--an endemic area for Lyme borreliosis. BMC Infect Dis. 2014 Apr 5;14:185. URL: https://pubmed.ncbi.nlm.nih.gov/24708707/</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. N Engl J Med. 1990 Nov 22;323(21):1438-44. URL: https://pubmed.ncbi.nlm.nih.gov/2172819/</mixed-citation><mixed-citation xml:lang="en">Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. N Engl J Med. 1990 Nov 22;323(21):1438-44. URL: https://pubmed.ncbi.nlm.nih.gov/2172819/</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Singh SK, Girschick HJ. Lyme borreliosis: from infection to autoimmunity. Clin Microbiol Infect. 2004 Jul;10(7):598-614. URL: https://pubmed.ncbi.nlm.nih.gov/15214872/</mixed-citation><mixed-citation xml:lang="en">Singh SK, Girschick HJ. Lyme borreliosis: from infection to autoimmunity. Clin Microbiol Infect. 2004 Jul;10(7):598-614. URL: https://pubmed.ncbi.nlm.nih.gov/15214872/</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dryden MS, Saeed K, Ogborn S, Swales P. Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiol Infect. 2015 Feb;143(3):561-72. URL: https://pubmed.ncbi.nlm.nih.gov/24814098/</mixed-citation><mixed-citation xml:lang="en">Dryden MS, Saeed K, Ogborn S, Swales P. Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiol Infect. 2015 Feb;143(3):561-72. URL: https://pubmed.ncbi.nlm.nih.gov/24814098/</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Спирин, Н.Н. Хронический боррелиозный энцефаломиелит / Н.Н. Спирин [и др.] // Медицинский альманах. – 2011. – Т. 14, № 1. – С. 161–164. – URL: https://cyberleninka.ru/article/n/hronicheskiy-borrelioznyyentsefalomielit</mixed-citation><mixed-citation xml:lang="en">Spirin N.N., Baranova N.S., Fadeeva O.A., Shipova E.G., Stepanov I.O. Hronicheskij borrelioznyj jencefalomielit // Medicinskij al’manah. – 2011. – Т. 14, № 1. – S. 161–164. URL: https://cyberleninka.ru/article/n/hronicheskiy-borrelioznyy-entsefalomielit</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Мокрецова Е.В. Кожные проявления хронического клещевого боррелиоза / Е.В. Мокрецова [и др.] // Дальневосточный журнал инфекционной патологии. – 2005. – № 6. – С. 45–46.</mixed-citation><mixed-citation xml:lang="en">Mokrecova E.V., Zhuravlev Ja.A., Zdanovskaja N.I., Burenkova V.V. Kozhnye projavlenija hronicheskogo kleshhevogo borrelioza// Dal’nevostochnyj Zhurnal Infekcionnoj Patologii. – 2005. – № 6. – S. 45–46.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Блажняя, Л.П. Клинические маски иксодового клещевого боррелиоза и сложности диагностики: систематический обзор / Л.П. Блажняя, М.Г. Авдеева, Д.Ю. Мошкова // Кубанский научный медицинский вестник. – 2021. – Т. 28, № 2. – С. 73–89. –URL: https://ksma.elpub.ru/jour/article/view/2400</mixed-citation><mixed-citation xml:lang="en">Blazhnjaja L. P., Avdeeva M. G., Moshkova D. Ju. Klinicheskie maski iksodovogo kleshhevogo borrelioza i slozhnosti diagnostiki: sistematicheskij obzor// Kubanskij nauchnyj medicinskij vestnik. – 2021. – Т. 28, № 2. – S. 73–89. URL: https://ksma.elpub.ru/jour/article/view/2400</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kuenzle S, von Büdingen HC, Meier M, Harrer MD, Urich E, Becher B, Goebels N. Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis. Infect Immun. 2007 Aug;75(8):3842-7. URL: https://pubmed.ncbi.nlm.nih.gov/17517881/</mixed-citation><mixed-citation xml:lang="en">Kuenzle S, von Büdingen HC, Meier M, Harrer MD, Urich E, Becher B, Goebels N. Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis. Infect Immun. 2007 Aug;75(8):3842-7. URL: https://pubmed.ncbi.nlm.nih.gov/17517881/</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kaminsky AL, Maisonobe T, Lenglet T, Psimaras D, Debs R, Viala K. Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system: Description of a cohort. Medicine (Baltimore). 2020 Oct 2;99(40):e21986. URL: https://pubmed.ncbi.nlm.nih.gov/33019390/</mixed-citation><mixed-citation xml:lang="en">Kaminsky AL, Maisonobe T, Lenglet T, Psimaras D, Debs R, Viala K. Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system: Description of a cohort. Medicine (Baltimore). 2020 Oct 2;99(40):e21986. URL: https://pubmed.ncbi.nlm.nih.gov/33019390/</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Doshi S, Keilp JG, Strobino B, McElhiney M, Rabkin J, Fallon BA. Depressive Symptoms and Suicidal Ideation Among Symptomatic Patients With a History of Lyme Disease vs Two Comparison Groups. Psychosomatics. 2018 Sep-Oct;59(5):481-489. URL: https://pubmed.ncbi.nlm.nih.gov/29606281/</mixed-citation><mixed-citation xml:lang="en">Doshi S, Keilp JG, Strobino B, McElhiney M, Rabkin J, Fallon BA. Depressive Symptoms and Suicidal Ideation Among Symptomatic Patients With a History of Lyme Disease vs Two Comparison Groups. Psychosomatics. 2018 Sep-Oct;59(5):481-489. URL: https://pubmed.ncbi.nlm.nih.gov/29606281/</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Vargas SE, McCarthy M, Boudreau M, Canfield D, Reece R, Flanigan T. Characterizing the Symptoms of Patients with Persistent Post-Treatment Lyme Symptoms: A Survey of Patients at a Lyme Disease Clinic in Rhode Island. R I Med J (2013). 2021 Apr 1;104(3):53-57. URL: https://pubmed.ncbi.nlm.nih.gov/33789412/</mixed-citation><mixed-citation xml:lang="en">Vargas SE, McCarthy M, Boudreau M, Canfield D, Reece R, Flanigan T. Characterizing the Symptoms of Patients with Persistent Post-Treatment Lyme Symptoms: A Survey of Patients at a Lyme Disease Clinic in Rhode Island. R I Med J (2013). 2021 Apr 1;104(3):53-57. URL: https://pubmed.ncbi.nlm.nih.gov/33789412/</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shui Y, Tao W, Huang D, Li Y, Fan B. Spinal cord stimulation for chronic pain originating from Lyme disease. Pain Physician. 2012 Nov-Dec;15(6):511-4. URL: https://pubmed.ncbi.nlm.nih.gov/23159969/</mixed-citation><mixed-citation xml:lang="en">Shui Y, Tao W, Huang D, Li Y, Fan B. Spinal cord stimulation for chronic pain originating from Lyme disease. Pain Physician. 2012 Nov-Dec;15(6):511-4. URL: https://pubmed.ncbi.nlm.nih.gov/23159969/</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gimsing LN, Hejl AM. Normal pressure hydrocephalus secondary to Lyme disease, a case report and review of seven reported cases. BMC Neurol. 2020 Sep 16;20(1):347. URL: https://pubmed.ncbi.nlm.nih.gov/32938426/</mixed-citation><mixed-citation xml:lang="en">Gimsing LN, Hejl AM. Normal pressure hydrocephalus secondary to Lyme disease, a case report and review of seven reported cases. BMC Neurol. 2020 Sep 16;20(1):347. URL: https://pubmed.ncbi.nlm.nih.gov/32938426/</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Randazzo JP, DiSpaltro FX, Cottrill C, Klainer AS, Steere AC, Bisaccia E. Successful treatment of a patient with chronic Lyme arthritis with extracorporeal photochemotherapy. J Am Acad Dermatol. 1994 May;30(5 Pt 2):908-10. URL: https://pubmed.ncbi.nlm.nih.gov/8169273/</mixed-citation><mixed-citation xml:lang="en">Randazzo JP, DiSpaltro FX, Cottrill C, Klainer AS, Steere AC, Bisaccia E. Successful treatment of a patient with chronic Lyme arthritis with extracorporeal photochemotherapy. J Am Acad Dermatol. 1994 May;30(5 Pt 2):908-10. URL: https://pubmed.ncbi.nlm.nih.gov/8169273/</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Шувалова, Е.П. Инфекционные болезни / Е.П. Шувалова [и др.] // СпецЛит. – 2015 – С. 328–339.</mixed-citation><mixed-citation xml:lang="en">Shuvalova E.P., Belozerov E.S., Beljaeva T.V., Zmushko E.I. Infekcionnye bolezni // SpecLit. – 2015 – S. 328–339.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sindic CJ, Depre A, Bigaignon G, Goubau PF, Hella P, Laterre C. Lymphocytic meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a clinical and serological study of 18 cases. J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1565-71. URL: https://pubmed.ncbi.nlm.nih.gov/3437290/</mixed-citation><mixed-citation xml:lang="en">Sindic CJ, Depre A, Bigaignon G, Goubau PF, Hella P, Laterre C. Lymphocytic meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a clinical and serological study of 18 cases. J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1565-71. URL: https://pubmed.ncbi.nlm.nih.gov/3437290/</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Баранова, Н.С. Поражение нервной системы при хроническом Лайм-боррелиозе / Н.С. Баранова, Н.Н. Спирин, В.А. Буланова // Медицинский совет. – 2012. – № 6. – С. 28–35. – URL: https://cyberleninka.ru/article/n/porazhenienervnoy-sistemy-pri-hronicheskom-laym-borrelioze</mixed-citation><mixed-citation xml:lang="en">Baranova N.S., Spirin N.N., Bulanova V.A. Porazhenie nervnoj sistemy pri hronicheskom Lajm-borrelioze// Medicinskij sovet. – 2012. – № 6. – S. 28–35. URL: https://cyberleninka.ru/article/n/porazhenie-nervnoy-sistemy-pri-hronicheskom-laym-borrelioze</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Шперлинг, М.М. Клинические аспекты диагностики клещевого боррелиоза / М.М. Шперлинг [и др.] // Бюллетень сибирской медицины. – 2008. – № 7. – С. 106–110. – URL: https://bulletin.ssmu.ru/jour/article/view/3883</mixed-citation><mixed-citation xml:lang="en">Shperling M.M., Tolokonskaja N.P., Fomenko N.V., Romanova E. V. Klinicheskie aspekty diagnostiki kleshhevogo borrelioza // Bjulleten’ sibirskoj mediciny. – 2008. – № 7. – S. 106–110. URL: https://bulletin.ssmu.ru/jour/article/view/3883</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Баранова, Н.С. Поражение нервной системы на отдаленных стадиях Лайм-боррелиоза / Н.С. Баранова [и др.] // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2010. – Т. 110, № 2. – С. 90–96. – URL: https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-skorsakova/2010/2/031997-72982010218</mixed-citation><mixed-citation xml:lang="en">Baranova N.S., Spirin N.N., Shipova E.G., Stepanov I.O. Porazhenie nervnoj sistemy na otdalennyh stadijah Lajmborrelioza // Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. – 2010. – Т. 110, № 2. – S. 90–96. URL: https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2010/2/031997-72982010218</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Matera G, Labate A, Quirino A, Lamberti AG, BorzÃ G, Barreca GS, Mumoli L, Peronace C, Giancotti A, Gambardella A, FocÃ A, Quattrone A. Chronic neuroborreliosis by B. garinii: an unusual case presenting with epilepsy and multifocal brain MRI lesions. New Microbiol. 2014 Jul;37(3):393-7. URL: https://pubmed.ncbi.nlm.nih.gov/25180856/</mixed-citation><mixed-citation xml:lang="en">Matera G, Labate A, Quirino A, Lamberti AG, BorzÃ G, Barreca GS, Mumoli L, Peronace C, Giancotti A, Gambardella A, FocÃ A, Quattrone A. Chronic neuroborreliosis by B. garinii: an unusual case presenting with epilepsy and multifocal brain MRI lesions. New Microbiol. 2014 Jul;37(3):393-7. URL: https://pubmed.ncbi.nlm.nih.gov/25180856/</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Haney C, Nahata MC. Unique expression of chronic Lyme disease and Jarisch-Herxheimer reaction to doxycycline therapy in a young adult. BMJ Case Rep. 2016 Jul 20;2016:bcr2013009433. URL: https://pubmed.ncbi.nlm.nih.gov/27440843/</mixed-citation><mixed-citation xml:lang="en">Haney C, Nahata MC. Unique expression of chronic Lyme disease and Jarisch-Herxheimer reaction to doxycycline therapy in a young adult. BMJ Case Rep. 2016 Jul 20;2016:bcr2013009433. URL: https://pubmed.ncbi.nlm.nih.gov/27440843/</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Chakravarty KK, Webley M, Summers GD. A case of chronic Lyme arthritis in England. Ann Rheum Dis. 1991 Feb;50(2):134-5. URL: https://pubmed.ncbi.nlm.nih.gov/1998391/</mixed-citation><mixed-citation xml:lang="en">Chakravarty KK, Webley M, Summers GD. A case of chronic Lyme arthritis in England. Ann Rheum Dis. 1991 Feb;50(2):134-5. URL: https://pubmed.ncbi.nlm.nih.gov/1998391/</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Аляутдина, Л.В. Опыт применения иммуноферментного анализа для диагностики Лайм-боррелиоза / Л.В. Аляутдина [и др.] // Медицинская паразитология и паразитарные болезни. – 2018. – № 1. – С. 37–40. – URL: http://medparasitology.com/wp-content/uploads/2019/11/Par1-18-19-21.pdf</mixed-citation><mixed-citation xml:lang="en">Aljautdina L.V., Semenova T.A., Dovgalev A.S., Midjannik G.A. Opyt primenenija immunofermentnogo analiza dlja diagnostiki Lajm-borrelioza // Medicinskaja parazitologija i parazitarnye bolezni. – 2018. – № 1. – S. 37–40. URL: http://medparasitology.com/wp-content/uploads/2019/11/Par1-18-19-21.pdf</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Соловей, Н.В. Последствия перенесенного клещевого боррелиоза: мифы и реальность с позиций доказательной медицины / Н.В. Соловей [и др.] // Инфекционные болезни. – 2013. – Т. 11, № 2. – С. 55–63. – URL: https://www.researchgate.net/publication/264976071</mixed-citation><mixed-citation xml:lang="en">Solovej N.V., Shherba V.V., Karpov I.A., Danilov D.E., Anis’ko L.A. Posledstvija perenesennogo kleshhevogo borrelioza: mify i real’nost’ s pozicij dokazatel’noj mediciny // Infekcionnye bolezni. – 2013. – Т. 11, № 2. – S. 55–63. URL: https://www.researchgate.net/publication/264976071</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Schmutzhard E, Pohl P, Stanek G. Borrelia burgdorferi antibodies in patients with relapsing/remitting form and chronic progressive form of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1215-8. URL: https://pubmed.ncbi.nlm.nih.gov/3225603/</mixed-citation><mixed-citation xml:lang="en">Schmutzhard E, Pohl P, Stanek G. Borrelia burgdorferi antibodies in patients with relapsing/remitting form and chronic progressive form of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1215-8. URL: https://pubmed.ncbi.nlm.nih.gov/3225603/</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cimmino MA, Accardo S. Long term treatment of chronic Lyme arthritis with benzathine penicillin. Ann Rheum Dis. 1992 Aug;51(8):1007-8. URL: https://pubmed.ncbi.nlm.nih.gov/1417107/</mixed-citation><mixed-citation xml:lang="en">Cimmino MA, Accardo S. Long term treatment of chronic Lyme arthritis with benzathine penicillin. Ann Rheum Dis. 1992 Aug;51(8):1007-8. URL: https://pubmed.ncbi.nlm.nih.gov/1417107/</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Coumou J, Herkes EA, Brouwer MC, van de Beek D, Tas SW, Casteelen G, van Vugt M, Starink MV, de Vries HJ, de Wever B, Spanjaard L, Hovius JW. Ticking the right boxes: classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands. Clin Microbiol Infect. 2015 Apr;21(4):368.e11-20. URL: https://pubmed.ncbi.nlm.nih.gov/25658524/</mixed-citation><mixed-citation xml:lang="en">Coumou J, Herkes EA, Brouwer MC, van de Beek D, Tas SW, Casteelen G, van Vugt M, Starink MV, de Vries HJ, de Wever B, Spanjaard L, Hovius JW. Ticking the right boxes: classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands. Clin Microbiol Infect. 2015 Apr;21(4):368.e11-20. URL: https://pubmed.ncbi.nlm.nih.gov/25658524/</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Miklossy J, Kasas S, Zurn AD, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J Neuroinflammation. 2008 Sep 25;5:40. URL: https://pubmed.ncbi.nlm.nih.gov/18817547/</mixed-citation><mixed-citation xml:lang="en">Miklossy J, Kasas S, Zurn AD, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J Neuroinflammation. 2008 Sep 25;5:40. URL: https://pubmed.ncbi.nlm.nih.gov/18817547/</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lebech AM, Hansen K. Detection of Borrelia burgdorferi DNA in urine samples and cerebrospinal fluid samples from patients with early and late Lyme neuroborreliosis by polymerase chain reaction. J Clin Microbiol. 1992 Jul;30(7):1646-53. URL: https://pubmed.ncbi.nlm.nih.gov/1629318/</mixed-citation><mixed-citation xml:lang="en">Lebech AM, Hansen K. Detection of Borrelia burgdorferi DNA in urine samples and cerebrospinal fluid samples from patients with early and late Lyme neuroborreliosis by polymerase chain reaction. J Clin Microbiol. 1992 Jul;30(7):1646-53. URL: https://pubmed.ncbi.nlm.nih.gov/1629318/</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med. 1994 Jan 27;330(4):229-34. URL: https://pubmed.ncbi.nlm.nih.gov/8272083/</mixed-citation><mixed-citation xml:lang="en">Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med. 1994 Jan 27;330(4):229-34. URL: https://pubmed.ncbi.nlm.nih.gov/8272083/</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Berek K, Hegen H, Auer M, Zinganell A, Di Pauli F, Deisenhammer F. Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi. PLoS One. 2020 Sep 25;15(9):e0239453. URL: https://pubmed.ncbi.nlm.nih.gov/32977328/</mixed-citation><mixed-citation xml:lang="en">Berek K, Hegen H, Auer M, Zinganell A, Di Pauli F, Deisenhammer F. Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi. PLoS One. 2020 Sep 25;15(9):e0239453. URL: https://pubmed.ncbi.nlm.nih.gov/32977328/</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Миноранская, Н.С. Клинико-иммунологические аспекты хронических иксодовых клещевых боррелиозов / Н.С. Миноранская [и др.] // Инфекционные болезни: новости, мнения, обучение. – 2020. – Т. 9, № 3. – С. 61–66. – URL: https://infect-dis-journal.ru/ru/jarticles_infection/712.html</mixed-citation><mixed-citation xml:lang="en">Minoranskaja N.S., Chernyh V.I., Tihonova E.P., Tjushevskaja O.A. Kliniko-immunologicheskie aspekty hronicheskih iksodovyh kleshhevyh borreliozov// Infekcionnye bolezni: novosti, mnenija, obuchenie. – 2020. – Т. 9, № 3. – S. 61–66. URL: https://infect-dis-journal.ru/ru/jarticles_infection/712.html</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
