jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2024-16-3-5-16jofin-1657Research ArticleОбзорыReviewФеномен вирусной хромосомной интеграцииThe phenomenon of viral chromosomal integrationГолеваО. В.GolevaO. V.

Голева Ольга Владимировна – старший научный сотрудник НИО экспериментальной медицинскойвирусологии, молекулярной генетики и биобанкинга, к.б.н.;

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cherkasovapv@yandex.ruБазиянЕ. В.BaziianE. V.

Базиян Елена Владимировна – младший научный сотрудник НИО экспериментальной медицинской вирусологии, молекулярной генетики и биобанкинга

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Иголкина Александра Александровна – аспирант НИО экспериментальной медицинской вирусологии,молекулярной генетики и биобанкинга

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Эйсмонт Юрий Александрович – старший научный сотрудник НИО экспериментальной медицинскойвирусологии, молекулярной генетики и биобанкинга, к.б.н.

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 Чухловин Алексей Борисович – заведующий лабораторией трансплантологии Научно-исследовательскогоинститута детской онкологии, гематологии и трансплантологии им. Р. М. Горбачевой ПервогоСанкт-Петербургского государственного медицинского университета им. академика И.П. Павлова, д.б.н., профессор

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alexei.chukh@mail.ruГлотовО. С.GlotovO. S.

Глотов Олег Сергеевич – заведующий НИО экспериментальной медицинской вирусологии, молекулярной генетики и биобанкинга, д.б.н., старшийнаучный сотрудник

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olglotov@mail.ruДетский научно-клинический центр инфекционных болезнейРоссияPediatric Research and Clinical Center for Infectious DiseasesRussian FederationДетский научно-клинический центр инфекционных болезней; Cанкт-Петербургский государственный педиатрический медицинский университетРоссияPediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical UniversityRussian FederationНаучно-исследовательский институт детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой Первого Санкт-Петербургского государственного медицинского университета им. академика И.П. ПавловаРоссияResearch Institute of Pediatric Oncology, Hematology and Transplantation named after R.M. Gorbacheva of First Saint-Petersburg State Medical University named after academician I.P. PavlovRussian Federation202420092024163516Copyright © Голева О.В., Черкасова П.В., Базиян Е.В., Иголкина А.А., Эйсмонт Ю.А., Скрипченко Н.В., Чухловин А.Б., Глотов О.С., 20242024Голева О.В., Черкасова П.В., Базиян Е.В., Иголкина А.А., Эйсмонт Ю.А., Скрипченко Н.В., Чухловин А.Б., Глотов О.С.Goleva O.V., Cherkasova P.V., Baziian E.V., Igolkina A.A., Ejsmont Y.A., Skripchenko N.V., Chukhlovin A.B., Glotov O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1657

Литературный обзор посвящен вирусам, интегрирующимся в ДНК хромосом, у которых с использованием современных методов диагностики, в том числе высокопроизводительного секвенирования, выявлена способность к интеграции. В обзоре описаны различные типы интегрирующихся вирусов, таких как ретровирусы, аденовирусы, герпес-вирусы, папилломавирусы, гепатит В, SARS-CoV-2 и др., представлены сведения о молекулярных механизмах вирусной интеграции, методах дифференциальной диагностики, приведены данные о распространенности. Каждый из этих вирусов имеет свои уникальные пути взаимодействия с геномом клетки-хозяина для поддержания латентного состояния, что определяет специфику инфекционного процесса и патологические последствия для организма в связи возможностью эффективной реактивации.

The literature review is devoted to the chromosomally integrating viruses, the integration property. These are revealed using modern diagnostic methods, including highthroughput sequencing. The review describes various types of viruses, such as retroviruses, adenoviruses, herpes viruses, papillomaviruses, hepatitis B, SARS-CoV-2 and others. These viruses have the ability to integrate their genomes into the host cell genomes and their prevalence. Modern information on the molecular mechanisms of viral integration and methods of differential diagnostics is presented. Each of these viruses has its own unique ways of interacting with the host cell genome to maintain a latent state, which determines the specifics of the infectious process and pathological consequences for the body due to the possibility of effective reactivation.

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The authors declare that there are no conflicts of interest present.