jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2024-16-2-17-27jofin-1636Research ArticleОбзорReviewПотенциальные биохимические маркеры-предикторы тяжелого течения инфекционных заболеваний у больных сахарным диабетом 2 типаPossible biochemical markers-predictors of severe course of infectious diseases in patients with type 2 diabetes mellitusКарасеваЕ. А.KarasevaE. A.

Карасева Елена Александровна – доцент кафедры инфекционных болезней и фтизиатрии; к.м.н.

Рязань

Ryazan

ekar83@gmail.comМартыновВ. А.MartynovV. A.

Мартынов Владимир Александрович – заведующий кафедрой инфекционных болезней и фтизиатрии; д.м.н.; профессор

Рязань

Ryazan

dr.martinov@mail.ruАбаленихинаЮ. В.AbalenikhinaYu. V.

Абаленихина Юлия Владимировна – профессор кафедры биологической химии; ведущий научный сотрудник ЦНИЛ; д.м.н.; доцент

Рязань

Ryazan

abalenihina88@mail.ruМуравлянниковН. С.MuravlyannikovN. S.

Муравлянников Никита Сергеевич – студент 6 курса лечебного факультета 

Рязань

Ryazan

muravlyannikov2099@gmail.comРязанский государственный медицинский университет им. академика И.П. ПавловаРоссияRyazan State Medical UniversityRussian Federation2024090720241621727Copyright © Карасева Е.А., Мартынов В.А., Абаленихина Ю.В., Муравлянников Н.С., 20242024Карасева Е.А., Мартынов В.А., Абаленихина Ю.В., Муравлянников Н.С.Karaseva E.A., Martynov V.A., Abalenikhina Y.V., Muravlyannikov N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1636

Пациенты с сахарным диабетом 2 типа часто имеют более тяжелое течение инфекционных заболеваний, что может быть связано с потенцированием хронического воспаления и окислительного стресса новым инфекционным фактором. Однако изучению проявлений окислительного стресса у пациентов с гипергликемией на фоне инфекционных заболеваний уделено мало внимания. Данный обзор раскрывает особенности состояния антиоксидантной системы у пациентов с сахарным диабетом 2 типа и посвящен определению возможных биохимических маркеров-предикторов тяжелого течения инфекций среди таких пациентов.

Potentiation of chronic inflammation and oxidative stress by a new infectious agent in patients with type 2 diabetes mellitus can cause a severe course of the infectious disease. However, the study of the manifestations of oxidative stress in patients with hyperglycemia and infectious diseases is not widespread. This review reveals the features of the state of the antioxidant system in patients with type 2 diabetes mellitus and is devoted to identifying possible biochemical markers that predict severe infections among such patients.

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The authors declare that there are no conflicts of interest present.